| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (3r,4r,5r,13ar,13br)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2h-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3h)-dione 1.33 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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56 genes differentially expressed following the CRCGN009_HEPG2_24H:I11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 6.1034 |
| CBR3 | carbonyl reductase 3 | 4.45995 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.47362 |
| HDGFL3 | HDGF like 3 | 3.44016 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 3.40355 |
| MYLK | myosin light chain kinase | 3.2934 |
| DIPK1A | divergent protein kinase domain 1A | 3.04243 |
| ABHD6 | abhydrolase domain containing 6 | 2.92233 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.86219 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.83323 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.80761 |
| KLHL9 | kelch-like family member 9 | 2.77787 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.77004 |
| CYCS | cytochrome c, somatic | 2.45125 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.44967 |
| SFTPB | surfactant protein B | 2.32269 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 2.31778 |
| CISD1 | CDGSH iron sulfur domain 1 | 2.27728 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 2.26912 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 2.26703 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 2.12233 |
| SUOX | sulfite oxidase | 2.12135 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.09608 |
| TRIM13 | tripartite motif containing 13 | 2.08484 |
| OXSM | 3-oxoacyl-ACP synthase, mitochondrial | 2.06 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 2.05808 |
| GATA2 | GATA binding protein 2 | 2.05735 |
| LMAN2L | lectin, mannose-binding 2-like | 2.04397 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 2.02126 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -7.26438 |
| PCNA | proliferating cell nuclear antigen | -6.68889 |
| TLR4 | toll-like receptor 4 | -5.995 |
| CCNB2 | cyclin B2 | -5.88021 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -5.41502 |
| RNF167 | ring finger protein 167 | -3.92535 |
| LDHD | lactate dehydrogenase D | -3.69073 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | -3.66981 |
| NRIP1 | nuclear receptor interacting protein 1 | -3.56204 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -3.43278 |
| MRPS16 | mitochondrial ribosomal protein S16 | -3.19654 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.85807 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.78205 |
| PEG10 | paternally expressed 10 | -2.66042 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.48971 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.47575 |
| STX4 | syntaxin 4 | -2.39223 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.34717 |
| VDAC1 | voltage-dependent anion channel 1 | -2.33945 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.24837 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.22644 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.20974 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.06942 |
| FBXO7 | F-box protein 7 | -2.04022 |
| GID4 | GID complex subunit 4 | -2.0381 |
| HMG20B | high mobility group 20B | -2.03094 |
| TREX2 | three prime repair exonuclease 2 | -2.01085 |
