CRCGN009_HEPG2_24H:I12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (3r,4r,5r,13ar,13br)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2h-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3h)-dione 0.66 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN009_HEPG2_24H:I12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.82826
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.52473
MSRA methionine sulfoxide reductase A 4.60755
DYNLT3 dynein, light chain, Tctex-type 3 4.35279
CARMIL1 capping protein regulator and myosin 1 linker 1 4.30967
LYN LYN proto-oncogene, Src family tyrosine kinase 4.15829
CXCR4 chemokine (C-X-C motif) receptor 4 3.82211
CHMP6 charged multivesicular body protein 6 3.28065
MAP7 microtubule-associated protein 7 3.18308
LAGE3 L antigen family, member 3 3.05192
CCNF cyclin F 2.76316
LOXL1 lysyl oxidase-like 1 2.62652
BACE2 beta-site APP-cleaving enzyme 2 2.59919
DIPK1A divergent protein kinase domain 1A 2.54908
TBPL1 TBP-like 1 2.48739
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.43911
MYLK myosin light chain kinase 2.38039
STK10 serine/threonine kinase 10 2.37845
TXNL4B thioredoxin-like 4B 2.27321
SATB1 SATB homeobox 1 2.23777
BCL2 B-cell CLL/lymphoma 2 2.21945
AMDHD2 amidohydrolase domain containing 2 2.20477
TATDN2 TatD DNase domain containing 2 2.20287
EPHB2 EPH receptor B2 2.19723
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.18716
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.18087
BAMBI BMP and activin membrane-bound inhibitor 2.17442
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.14312
BIRC2 baculoviral IAP repeat containing 2 2.03994

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -4.88602
TRIB3 tribbles pseudokinase 3 -4.54474
TLR4 toll-like receptor 4 -4.05687
TM9SF2 transmembrane 9 superfamily member 2 -3.94622
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.90073
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.35318
CPNE3 copine III -3.07795
OXA1L oxidase (cytochrome c) assembly 1-like -2.99617
LOC124907782 dual specificity protein phosphatase 22 -2.88595
EGF epidermal growth factor -2.88477
ZMIZ1 zinc finger, MIZ-type containing 1 -2.78414
LGMN legumain -2.70008
CDC25B cell division cycle 25B -2.68892
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.68869
ZW10 zw10 kinetochore protein -2.43673
PRPF4 pre-mRNA processing factor 4 -2.43279
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 -2.39339
LDHD lactate dehydrogenase D -2.36316
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -2.28844
CCNB2 cyclin B2 -2.26651
ACAA1 acetyl-CoA acyltransferase 1 -2.21278
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.13928
FAIM Fas apoptotic inhibitory molecule -2.10044
SESN1 sestrin 1 -2.02663
STEAP3 STEAP family member 3, metalloreductase -2.01458