CRCGN009_HEPG2_24H:I13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 21.82 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

197 genes differentially expressed following the CRCGN009_HEPG2_24H:I13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EPHB2 EPH receptor B2 7.71081
RPL39L ribosomal protein L39-like 7.1721
MAP7 microtubule-associated protein 7 5.38232
MAMLD1 mastermind-like domain containing 1 5.15648
LCN2 lipocalin 2 4.94969
RAB11FIP1 RAB11 family interacting protein 1 (class I) 4.10819
NANOS3 nanos homolog 3 (Drosophila) 3.96738
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.94196
TBPL1 TBP-like 1 3.87827
NOTCH1 notch 1 3.72141
CHN1 chimerin 1 3.51165
GATA2 GATA binding protein 2 3.47176
PPARG peroxisome proliferator-activated receptor gamma 3.44431
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.41267
EPHA3 EPH receptor A3 3.41147
FCHO1 FCH domain only 1 3.37979
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 3.33823
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.30878
CCDC92 coiled-coil domain containing 92 3.27052
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.24542
MYLK myosin light chain kinase 3.22507
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.2229
PIH1D1 PIH1 domain containing 1 3.18301
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.15281
ADRB2 adrenoceptor beta 2, surface 3.07902
LAGE3 L antigen family, member 3 3.05257
RAB4A RAB4A, member RAS oncogene family 2.99956
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.9931
TAC4 tachykinin 4 (hemokinin) 2.97555
SNAP25 synaptosomal-associated protein, 25kDa 2.96544
DEFA6 defensin, alpha 6, Paneth cell-specific 2.95934
MOK MOK protein kinase 2.89466
DEFA5 defensin, alpha 5, Paneth cell-specific 2.85465
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.83199
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.82936
CBR1 carbonyl reductase 1 2.80639
CARMIL1 capping protein regulator and myosin 1 linker 1 2.79306
PMM2 phosphomannomutase 2 2.71165
IL1B interleukin 1, beta 2.69909
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.69818
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.6806
CDX1 caudal type homeobox 1 2.67839
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 2.65814
HOXA10 homeobox A10 2.65563
REG3A regenerating islet-derived 3 alpha 2.60721
MSRA methionine sulfoxide reductase A 2.57457
MMP2 matrix metallopeptidase 2 2.57003
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.55508
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.54816
GTF2IRD2B GTF2I repeat domain containing 2B 2.53747
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.52042
MMP3 matrix metallopeptidase 3 2.48687
UBASH3A ubiquitin associated and SH3 domain containing A 2.44431
NPY4R2 neuropeptide Y receptor Y4-2 2.44197
COL4A1 collagen, type IV, alpha 1 2.43974
POM121L2 POM121 transmembrane nucleoporin-like 2 2.43164
HMOX1 heme oxygenase 1 2.42406
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.41721
CBR3 carbonyl reductase 3 2.40924
JADE2 jade family PHD finger 2 2.40749
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.3969
TIAM1 T-cell lymphoma invasion and metastasis 1 2.38098
MYRIP myosin VIIA and Rab interacting protein 2.37799
LOC107985101 uncharacterized LOC107985101 2.37276
CLDN3 claudin 3 2.36924
IL5 interleukin 5 2.33001
SOX17 SRY (sex determining region Y)-box 17 2.32229
SLC66A3 solute carrier family 66 member 3 2.315
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.31071
PLD3 phospholipase D family, member 3 2.29989
ZNF493 zinc finger protein 493 2.29884
NKX2-5 NK2 homeobox 5 2.2976
TESMIN testis expressed metallothionein like protein 2.29095
OXCT1 3-oxoacid CoA transferase 1 2.28637
DNAH2 dynein, axonemal, heavy chain 2 2.28283
REG1B regenerating islet-derived 1 beta 2.28021
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 2.26763
KLHL9 kelch-like family member 9 2.26368
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.2602
COQ8B coenzyme Q8B 2.24515
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.23993
WDR7 WD repeat domain 7 2.23456
CHODL chondrolectin 2.22391
BTK Bruton agammaglobulinemia tyrosine kinase 2.21879
IFNB1 interferon, beta 1, fibroblast 2.21712
FGF16 fibroblast growth factor 16 2.20927
PAX1 paired box 1 2.20173
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.20065
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.19561
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.19174
TESPA1 thymocyte expressed, positive selection associated 1 2.18043
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.17842
GLT8D2 glycosyltransferase 8 domain containing 2 2.17833
PEX11A peroxisomal biogenesis factor 11 alpha 2.17691
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 2.17441
SPATA6L spermatogenesis associated 6-like 2.16888
VENTX VENT homeobox 2.16569
FANCF Fanconi anemia, complementation group F 2.16519
NRCAM neuronal cell adhesion molecule 2.16487
FN3K fructosamine 3 kinase 2.16253
VWA7 von Willebrand factor A domain containing 7 2.15295
INSIG1 insulin induced gene 1 2.14152
GUCA1B guanylate cyclase activator 1B (retina) 2.13922
TRAM2 translocation associated membrane protein 2 2.13667
GLI2 GLI family zinc finger 2 2.13582
SNAI1 snail family zinc finger 1 2.13276
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.12616
PITPNM3 PITPNM family member 3 2.12523
IL13 interleukin 13 2.12084
TEX28 testis expressed 28 2.11852
CD40LG CD40 ligand 2.11607
ADNP activity-dependent neuroprotector homeobox 2.11528
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.11222
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2.11109
ZNF589 zinc finger protein 589 2.1076
GPR15 G protein-coupled receptor 15 2.1019
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.09635
GPR68 G protein-coupled receptor 68 2.0958
TMEM223 transmembrane protein 223 2.09172
LBX1 ladybird homeobox 1 2.09093
PLSCR3 phospholipid scramblase 3 2.08302
NTN1 netrin 1 2.06734
CCL2 chemokine (C-C motif) ligand 2 2.06347
OLFML2A olfactomedin-like 2A 2.05965
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.0548
ZSCAN16 zinc finger and SCAN domain containing 16 2.04868
CISD1 CDGSH iron sulfur domain 1 2.0473
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 2.04075
SKI SKI proto-oncogene 2.04041
CPPED1 calcineurin-like phosphoesterase domain containing 1 2.02843
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.02553
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 2.02297
IRGC immunity-related GTPase family, cinema 2.02169
AANAT aralkylamine N-acetyltransferase 2.01976
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.01645
NUP37 nucleoporin 37kDa 2.0139
NXPH4 neurexophilin 4 2.00892
CARTPT CART prepropeptide 2.00882
IL24 interleukin 24 2.00631
NPBWR2 neuropeptides B/W receptor 2 2.00369

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -5.80977
TLR4 toll-like receptor 4 -4.80783
DUSP6 dual specificity phosphatase 6 -4.34074
LOC124907782 dual specificity protein phosphatase 22 -3.93293
CAB39 calcium binding protein 39 -3.788
ARID5B AT rich interactive domain 5B (MRF1-like) -3.40034
ZMIZ1 zinc finger, MIZ-type containing 1 -3.35023
TLCD3A TLC domain containing 3A -3.33371
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.25544
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.2272
SPAG4 sperm associated antigen 4 -3.16939
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.09413
PCNA proliferating cell nuclear antigen -2.94085
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.93814
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.905
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.87535
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.80574
VDAC1 voltage-dependent anion channel 1 -2.78136
INTS3 integrator complex subunit 3 -2.77056
UBE3C ubiquitin protein ligase E3C -2.76782
MRPS2 mitochondrial ribosomal protein S2 -2.71284
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.66409
CLTB clathrin, light chain B -2.60321
ANXA10 annexin A10 -2.55121
GTPBP8 GTP-binding protein 8 (putative) -2.54445
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.5276
TM9SF3 transmembrane 9 superfamily member 3 -2.52187
MUS81 MUS81 structure-specific endonuclease subunit -2.48432
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -2.4162
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -2.39773
BLCAP bladder cancer associated protein -2.37666
GET1 guided entry of tail-anchored proteins factor 1 -2.36203
HSPB8 heat shock 22kDa protein 8 -2.33822
TWF2 twinfilin actin binding protein 2 -2.33532
FBXL12 F-box and leucine-rich repeat protein 12 -2.32841
CTSE cathepsin E -2.29825
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.28017
EIF5 eukaryotic translation initiation factor 5 -2.23377
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.23085
BEX2 brain expressed X-linked 2 -2.1958
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -2.19515
STAT1 signal transducer and activator of transcription 1, 91kDa -2.15766
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.14702
HAX1 HCLS1 associated protein X-1 -2.14317
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.12024
NCK1 NCK adaptor protein 1 -2.11735
MACF1 microtubule-actin crosslinking factor 1 -2.11712
TACC2 transforming, acidic coiled-coil containing protein 2 -2.09766
YME1L1 YME1-like 1 ATPase -2.08884
MOGS mannosyl-oligosaccharide glucosidase -2.06353
ACAA1 acetyl-CoA acyltransferase 1 -2.06238
NT5DC2 5'-nucleotidase domain containing 2 -2.0612
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.05974
CCNB2 cyclin B2 -2.03661
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.03658
STK25 serine/threonine kinase 25 -2.00925
ZNF668 zinc finger protein 668 -2.00334