| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 5.46 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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84 genes differentially expressed following the CRCGN009_HEPG2_24H:I15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPARG | peroxisome proliferator-activated receptor gamma | 6.85578 |
| LCN2 | lipocalin 2 | 6.65661 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 6.55769 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 5.01938 |
| CHMP6 | charged multivesicular body protein 6 | 4.4011 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.03807 |
| STIMATE | STIM activating enhancer | 3.75992 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 3.68891 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.47786 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 3.24712 |
| E2F2 | E2F transcription factor 2 | 3.15441 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.13906 |
| CYCS | cytochrome c, somatic | 3.11868 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 3.11462 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 3.04893 |
| ABHD6 | abhydrolase domain containing 6 | 2.64136 |
| DIPK1A | divergent protein kinase domain 1A | 2.49415 |
| ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | 2.46301 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.44736 |
| PLSCR1 | phospholipid scramblase 1 | 2.43205 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.33921 |
| HMOX1 | heme oxygenase 1 | 2.32282 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | 2.25679 |
| ETFA | electron-transfer-flavoprotein, alpha polypeptide | 2.2564 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 2.21076 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.17351 |
| STXBP2 | syntaxin binding protein 2 | 2.14898 |
| OXSM | 3-oxoacyl-ACP synthase, mitochondrial | 2.13348 |
| IDE | insulin-degrading enzyme | 2.10669 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 2.1055 |
| GPR15 | G protein-coupled receptor 15 | 2.09665 |
| RAB5C | RAB5C, member RAS oncogene family | 2.0491 |
| RHBG | Rh family, B glycoprotein (gene/pseudogene) | 2.04843 |
| EGF | epidermal growth factor | 2.03096 |
| NUP107 | nucleoporin 107kDa | 2.02997 |
| AXIN1 | axin 1 | 2.02147 |
| NOSIP | nitric oxide synthase interacting protein | 2.02049 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF586 | zinc finger protein 586 | -8.88719 |
| MAPK13 | mitogen-activated protein kinase 13 | -4.72042 |
| GNAS | GNAS complex locus | -4.52645 |
| CCNB2 | cyclin B2 | -4.38422 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -4.11597 |
| ADI1 | acireductone dioxygenase 1 | -3.7686 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.61373 |
| SNX11 | sorting nexin 11 | -3.60374 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.59992 |
| CCNB1 | cyclin B1 | -3.49413 |
| TBCB | tubulin folding cofactor B | -3.02681 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -3.0015 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.97687 |
| WDR7 | WD repeat domain 7 | -2.73727 |
| TLR4 | toll-like receptor 4 | -2.62941 |
| ZNF587B | zinc finger protein 587B | -2.56097 |
| GUCY1A1 | guanylate cyclase 1 soluble subunit alpha 1 | -2.53573 |
| RHEB | Ras homolog enriched in brain | -2.48429 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.47323 |
| ZNF10 | zinc finger protein 10 | -2.42897 |
| PCNA | proliferating cell nuclear antigen | -2.3893 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.35934 |
| YEATS2 | YEATS domain containing 2 | -2.35566 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.33837 |
| GTPBP8 | GTP-binding protein 8 (putative) | -2.32417 |
| KDR | kinase insert domain receptor | -2.30854 |
| RGS2 | regulator of G-protein signaling 2 | -2.27062 |
| EHD3 | EH-domain containing 3 | -2.25374 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | -2.25336 |
| CCNH | cyclin H | -2.24378 |
| EDNRA | endothelin receptor type A | -2.23963 |
| RHOBTB2 | Rho-related BTB domain containing 2 | -2.22211 |
| ANOS1 | anosmin 1 | -2.21582 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | -2.20301 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -2.1757 |
| PHF20L1 | PHD finger protein 20-like 1 | -2.16898 |
| TNFSF15 | tumor necrosis factor (ligand) superfamily, member 15 | -2.13057 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -2.12648 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.12145 |
| ZNF551 | zinc finger protein 551 | -2.10462 |
| LY6G6F-LY6G6D | LY6G6F-LY6G6D readthrough | -2.06831 |
| NDRG4 | NDRG family member 4 | -2.05901 |
| ZNF134 | zinc finger protein 134 | -2.05512 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.02762 |
| TLCD3A | TLC domain containing 3A | -2.0156 |
| ZNF222 | zinc finger protein 222 | -2.01065 |
| ZSCAN9 | zinc finger and SCAN domain containing 9 | -2.00436 |
