CRCGN009_HEPG2_24H:I16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 2.73 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN009_HEPG2_24H:I16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 7.26981
MAP7 microtubule-associated protein 7 6.52105
C2CD2 C2 calcium-dependent domain containing 2 4.78418
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.62852
CBR3 carbonyl reductase 3 4.38335
CARMIL1 capping protein regulator and myosin 1 linker 1 4.36699
ALDOC aldolase C, fructose-bisphosphate 4.23249
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.23151
CYCS cytochrome c, somatic 4.05451
RPL39L ribosomal protein L39-like 3.97991
UBQLN2 ubiquilin 2 3.94702
IDE insulin-degrading enzyme 3.93503
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.34038
PFKL phosphofructokinase, liver 3.14317
GSTZ1 glutathione S-transferase zeta 1 2.99397
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.78262
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.55409
GPER1 G protein-coupled estrogen receptor 1 2.47661
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.46276
ATP11B ATPase, class VI, type 11B 2.46016
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.41855
LPAR2 lysophosphatidic acid receptor 2 2.35981
TIAM1 T-cell lymphoma invasion and metastasis 1 2.3587
JADE2 jade family PHD finger 2 2.21813
RPA3 replication protein A3, 14kDa 2.11921
KLHL9 kelch-like family member 9 2.04879
TYRP1 tyrosinase-related protein 1 2.02064

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.11198
PCNA proliferating cell nuclear antigen -5.09274
LDHD lactate dehydrogenase D -5.06364
CSK c-src tyrosine kinase -4.87102
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.59315
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.24234
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.19997
GNAS GNAS complex locus -3.92267
MAPK13 mitogen-activated protein kinase 13 -3.72566
CCNB2 cyclin B2 -3.41859
RAI14 retinoic acid induced 14 -2.39908
TM6SF1 transmembrane 6 superfamily member 1 -2.28596
NRIP1 nuclear receptor interacting protein 1 -2.19452
HYOU1 hypoxia up-regulated 1 -2.178
GIMAP4 GTPase, IMAP family member 4 -2.10295
LPIN2 lipin 2 -2.0968
AICDA activation-induced cytidine deaminase -2.0521
PRPF4 pre-mRNA processing factor 4 -2.02626