CRCGN009_HEPG2_24H:I17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 1.36 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN009_HEPG2_24H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 6.98081
MAP7 microtubule-associated protein 7 5.57916
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.22404
HLA-DMA major histocompatibility complex, class II, DM alpha 4.122
EPHA3 EPH receptor A3 4.04375
CXCL2 chemokine (C-X-C motif) ligand 2 3.90579
BACE2 beta-site APP-cleaving enzyme 2 3.80198
EAPP E2F-associated phosphoprotein 3.76529
CHMP6 charged multivesicular body protein 6 3.63291
STK10 serine/threonine kinase 10 3.55084
JADE2 jade family PHD finger 2 3.52964
LCN2 lipocalin 2 3.51327
CXCR4 chemokine (C-X-C motif) receptor 4 3.12995
PPARG peroxisome proliferator-activated receptor gamma 3.11586
SNAP25 synaptosomal-associated protein, 25kDa 3.10185
GATA3 GATA binding protein 3 3.09409
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.79942
EVL Enah/Vasp-like 2.64001
EPN2 epsin 2 2.5923
HLA-DRA major histocompatibility complex, class II, DR alpha 2.5704
CCNF cyclin F 2.55836
CNGA3 cyclic nucleotide gated channel alpha 3 2.34984
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.34926
VGLL4 vestigial-like family member 4 2.33218
HMOX1 heme oxygenase 1 2.33028
STXBP2 syntaxin binding protein 2 2.32604
GPR85 G protein-coupled receptor 85 2.31859
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.2945
TNN tenascin N 2.27177
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 2.26742
CD5L CD5 molecule-like 2.25051
POU3F4 POU class 3 homeobox 4 2.24662
CNTN5 contactin 5 2.22023
ZBTB33 zinc finger and BTB domain containing 33 2.21987
PCDHB11 protocadherin beta 11 2.21642
CINP cyclin-dependent kinase 2 interacting protein 2.1643
EGF epidermal growth factor 2.15678
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.15595
RBMXL2 RNA binding motif protein, X-linked-like 2 2.15227
PAPOLB poly(A) polymerase beta (testis specific) 2.14885
SPICE1 spindle and centriole associated protein 1 2.1448
TIAM1 T-cell lymphoma invasion and metastasis 1 2.14451
FPGT-TNNI3K FPGT-TNNI3K readthrough 2.14318
ETV3 ets variant 3 2.14291
RAD21L1 RAD21-like 1 (S. pombe) 2.13086
CNTN6 contactin 6 2.11887
SPATA31C1 SPATA31 subfamily C, member 1 2.11376
TRPC5 transient receptor potential cation channel, subfamily C, member 5 2.09778
PKD2L2 polycystic kidney disease 2-like 2 2.09536
HCRTR1 hypocretin (orexin) receptor 1 2.09438
SPO11 SPO11 meiotic protein covalently bound to DSB 2.07492
OTUD7B OTU deubiquitinase 7B 2.07331
CHEK2 checkpoint kinase 2 2.06756
CFAP68 cilia and flagella associated protein 68 2.06136
RNF32 ring finger protein 32 2.05936
MAGEB3 melanoma antigen family B3 2.0575
BICDL1 BICD family like cargo adaptor 1 2.05669
TIGD6 tigger transposable element derived 6 2.05588
CFAP43 cilia and flagella associated protein 43 2.05521
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.05341
GLRA3 glycine receptor, alpha 3 2.05317
ADGB androglobin 2.04924
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.0445
UPK3A uroplakin 3A 2.0442
SNTG2 syntrophin, gamma 2 2.03895
MROH9 maestro heat-like repeat family member 9 2.02775
PRDM9 PR domain containing 9 2.02562
PPIAL4H peptidylprolyl isomerase A like 4H 2.0217
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.02162
SOCS2 suppressor of cytokine signaling 2 2.02024
TAS2R9 taste receptor, type 2, member 9 2.01934
OR2B2 olfactory receptor, family 2, subfamily B, member 2 2.01638
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.01491
RNLS renalase, FAD-dependent amine oxidase 2.01375
WNT8B wingless-type MMTV integration site family, member 8B 2.00898
ACOXL acyl-CoA oxidase-like 2.00637
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.00532
ELAC1 elaC ribonuclease Z 1 2.00407
CHN1 chimerin 1 2.00158

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.13229
LDHD lactate dehydrogenase D -6.22604
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.18077
ZNF586 zinc finger protein 586 -5.58574
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.3308
PCNA proliferating cell nuclear antigen -3.27733
CD320 CD320 molecule -3.1114
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.06489
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.99491
CTSD cathepsin D -2.80079
KDM3A lysine (K)-specific demethylase 3A -2.70545
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.66327
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.62953
PSRC1 proline/serine-rich coiled-coil 1 -2.44009
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.23049
MACF1 microtubule-actin crosslinking factor 1 -2.22299
RNF167 ring finger protein 167 -2.20211
CCNB2 cyclin B2 -2.16675