| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 0.68 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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61 genes differentially expressed following the CRCGN009_HEPG2_24H:I18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPARG | peroxisome proliferator-activated receptor gamma | 8.75861 |
| TBPL1 | TBP-like 1 | 5.63455 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 5.25295 |
| CHN1 | chimerin 1 | 4.7347 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.64946 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.52277 |
| LCN2 | lipocalin 2 | 4.43339 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.31368 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 4.11731 |
| UBQLN2 | ubiquilin 2 | 3.99037 |
| ATP11B | ATPase, class VI, type 11B | 3.93568 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 3.62887 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 3.21946 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 2.94775 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | 2.91325 |
| TXNL4B | thioredoxin-like 4B | 2.83934 |
| FAIM | Fas apoptotic inhibitory molecule | 2.77174 |
| TPD52L2 | tumor protein D52-like 2 | 2.57638 |
| ZNF589 | zinc finger protein 589 | 2.5527 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.48817 |
| DPH2 | DPH2 homolog (S. cerevisiae) | 2.3696 |
| CCNF | cyclin F | 2.35269 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.35127 |
| GPATCH8 | G patch domain containing 8 | 2.30899 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.18911 |
| TMEM50A | transmembrane protein 50A | 2.12343 |
| TM4SF4 | transmembrane 4 L six family member 4 | 2.08342 |
| HMOX1 | heme oxygenase 1 | 2.07042 |
| DIPK1A | divergent protein kinase domain 1A | 2.06441 |
| MAGED4B | melanoma antigen family D4B | 2.01899 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -8.67299 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -7.52075 |
| ZNF586 | zinc finger protein 586 | -5.71061 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.28229 |
| DUSP6 | dual specificity phosphatase 6 | -5.09612 |
| CDC20 | cell division cycle 20 | -4.79201 |
| RPIA | ribose 5-phosphate isomerase A | -4.69626 |
| TRIB3 | tribbles pseudokinase 3 | -4.54822 |
| ISOC1 | isochorismatase domain containing 1 | -4.54116 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -4.51552 |
| NRIP1 | nuclear receptor interacting protein 1 | -4.31283 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -4.25378 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -4.24867 |
| MAPK13 | mitogen-activated protein kinase 13 | -4.06013 |
| VAT1 | vesicle amine transport 1 | -4.05551 |
| ADI1 | acireductone dioxygenase 1 | -3.9777 |
| TLCD3A | TLC domain containing 3A | -3.61013 |
| SNX11 | sorting nexin 11 | -3.60245 |
| PCNA | proliferating cell nuclear antigen | -3.58253 |
| TLR4 | toll-like receptor 4 | -3.35471 |
| GNAS | GNAS complex locus | -3.11018 |
| CSK | c-src tyrosine kinase | -3.02647 |
| PDHX | pyruvate dehydrogenase complex, component X | -2.90427 |
| PEG10 | paternally expressed 10 | -2.85981 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.7562 |
| CCNB2 | cyclin B2 | -2.62308 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.48383 |
| EGF | epidermal growth factor | -2.29029 |
| KLHL12 | kelch-like family member 12 | -2.17348 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -2.11982 |
| UGDH | UDP-glucose 6-dehydrogenase | -2.01209 |
