CRCGN009_HEPG2_24H:I21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(2-bromo-2-ethylbutanoyl)urea 5.06 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

92 genes differentially expressed following the CRCGN009_HEPG2_24H:I21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.69783
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.49858
PPARG peroxisome proliferator-activated receptor gamma 5.93618
UBQLN2 ubiquilin 2 5.37638
GPER1 G protein-coupled estrogen receptor 1 4.8251
RPL39L ribosomal protein L39-like 4.31786
CCDC92 coiled-coil domain containing 92 4.27852
NOTCH1 notch 1 4.27357
HLA-DMA major histocompatibility complex, class II, DM alpha 4.04715
E2F2 E2F transcription factor 2 3.92983
TRIM13 tripartite motif containing 13 3.90809
HOXA10 homeobox A10 3.71119
AMDHD2 amidohydrolase domain containing 2 3.66925
SYNE2 spectrin repeat containing, nuclear envelope 2 3.63632
EPHB2 EPH receptor B2 3.6162
ABHD4 abhydrolase domain containing 4 3.37916
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.18195
EPHA3 EPH receptor A3 3.06933
LPAR2 lysophosphatidic acid receptor 2 3.0327
IL1B interleukin 1, beta 2.99695
CCL2 chemokine (C-C motif) ligand 2 2.95626
UBE2A ubiquitin-conjugating enzyme E2A 2.93244
TRAM2 translocation associated membrane protein 2 2.66274
STIMATE STIM activating enhancer 2.65226
CHN1 chimerin 1 2.58525
TRAPPC2L trafficking protein particle complex 2-like 2.55234
VSX1 visual system homeobox 1 2.48027
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.42904
HOXA11 homeobox A11 2.42367
TAC4 tachykinin 4 (hemokinin) 2.4007
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.34647
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.30113
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.27783
LHX5 LIM homeobox 5 2.2606
KLHL1 kelch-like family member 1 2.24835
SF3B4 splicing factor 3b, subunit 4, 49kDa 2.24761
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.24601
DGKH diacylglycerol kinase, eta 2.22046
PSPN persephin 2.20551
CCL24 chemokine (C-C motif) ligand 24 2.17121
ZBTB32 zinc finger and BTB domain containing 32 2.13888
ICAM1 intercellular adhesion molecule 1 2.12779
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.12249
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.12217
SSTR5 somatostatin receptor 5 2.06888
UTP11 UTP11 small subunit processome component 2.05293
MEST mesoderm specific transcript 2.04769
COPS7A COP9 signalosome subunit 7A 2.04548
PDCD1 programmed cell death 1 2.03817
GNG10 guanine nucleotide binding protein (G protein), gamma 10 2.03096
CERS1 ceramide synthase 1 2.02784
TBC1D31 TBC1 domain family, member 31 2.02647
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.01633
SORBS1 sorbin and SH3 domain containing 1 2.01284
ACAN aggrecan 2.00929
PXMP2 peroxisomal membrane protein 2, 22kDa 2.00672
MATN4 matrilin 4 2.001

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -7.04888
LDHD lactate dehydrogenase D -6.03454
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.86698
NT5DC2 5'-nucleotidase domain containing 2 -5.79953
GNAS GNAS complex locus -5.65574
CCNB2 cyclin B2 -4.81186
TLR4 toll-like receptor 4 -4.77974
TRIB3 tribbles pseudokinase 3 -4.19242
KDM3A lysine (K)-specific demethylase 3A -3.93256
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.70649
C2CD5 C2 calcium-dependent domain containing 5 -3.63698
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.51031
CDC25B cell division cycle 25B -3.40571
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.2695
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.21436
SNX11 sorting nexin 11 -3.13848
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.13409
CHMP4B charged multivesicular body protein 4B -2.9305
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.88586
EGF epidermal growth factor -2.67609
ZMIZ1 zinc finger, MIZ-type containing 1 -2.65543
PECR peroxisomal trans-2-enoyl-CoA reductase -2.58196
CSK c-src tyrosine kinase -2.57012
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.47312
PHF21A PHD finger protein 21A -2.44907
HYOU1 hypoxia up-regulated 1 -2.35575
SIRT1 sirtuin 1 -2.28057
PRSS3 protease, serine, 3 -2.2333
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.21419
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.1991
LGMN legumain -2.18812
BTBD3 BTB (POZ) domain containing 3 -2.18376
PRSS21 protease, serine, 21 (testisin) -2.0735
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.0282
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.00634