CRCGN009_HEPG2_24H:J01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 20.71 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN009_HEPG2_24H:J01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ATP11B ATPase, class VI, type 11B 5.2614
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.08789
BACE2 beta-site APP-cleaving enzyme 2 4.96538
E2F2 E2F transcription factor 2 4.92134
RPL39L ribosomal protein L39-like 4.73553
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.00525
CYCS cytochrome c, somatic 3.41546
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.29821
PRR15L proline rich 15-like 3.18466
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.12896
MAP7 microtubule-associated protein 7 3.11008
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.91882
RAB21 RAB21, member RAS oncogene family 2.78096
MAST2 microtubule associated serine/threonine kinase 2 2.70921
LPAR2 lysophosphatidic acid receptor 2 2.59777
SOCS2 suppressor of cytokine signaling 2 2.47308
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.41488
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.28133
GNPDA1 glucosamine-6-phosphate deaminase 1 2.12841
GATA2 GATA binding protein 2 2.00542

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.2266
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.19396
NRIP1 nuclear receptor interacting protein 1 -4.97972
PCNA proliferating cell nuclear antigen -4.92664
CAB39 calcium binding protein 39 -4.32256
MAPK13 mitogen-activated protein kinase 13 -3.65721
TLR4 toll-like receptor 4 -3.48286
EGF epidermal growth factor -3.27279
GNAS GNAS complex locus -3.07166
ACAA1 acetyl-CoA acyltransferase 1 -2.897
FBXO7 F-box protein 7 -2.63467
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.58131
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.55306
DDIT4 DNA-damage-inducible transcript 4 -2.45036
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.43783
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.3849
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.37995
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.25741
LDHD lactate dehydrogenase D -2.23812
CXCL2 chemokine (C-X-C motif) ligand 2 -2.21524
TCTN1 tectonic family member 1 -2.16564
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.04075
ZNF586 zinc finger protein 586 -2.02656
LY6G6F-LY6G6D LY6G6F-LY6G6D readthrough -2.02263