| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 5.18 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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145 genes differentially expressed following the CRCGN009_HEPG2_24H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 7.43722 |
| MAP7 | microtubule-associated protein 7 | 7.35651 |
| NOTCH1 | notch 1 | 6.43843 |
| HOXA10 | homeobox A10 | 6.35136 |
| UBQLN2 | ubiquilin 2 | 5.33202 |
| CCL2 | chemokine (C-C motif) ligand 2 | 5.29146 |
| GPER1 | G protein-coupled estrogen receptor 1 | 5.1532 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 5.05568 |
| EPHB2 | EPH receptor B2 | 4.90534 |
| LCN2 | lipocalin 2 | 4.87806 |
| FCHO1 | FCH domain only 1 | 4.76869 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 4.55731 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 4.02659 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 3.9151 |
| CHMP6 | charged multivesicular body protein 6 | 3.73902 |
| WDR7 | WD repeat domain 7 | 3.47859 |
| MAMLD1 | mastermind-like domain containing 1 | 3.31171 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.26459 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.24973 |
| RXYLT1 | ribitol xylosyltransferase 1 | 3.15224 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 3.04975 |
| CRTAP | cartilage associated protein | 3.02604 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 3.02574 |
| GAA | glucosidase, alpha; acid | 2.98934 |
| TAC4 | tachykinin 4 (hemokinin) | 2.98492 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.93906 |
| HOXA10-HOXA9 | HOXA10-HOXA9 readthrough | 2.82115 |
| SATB1 | SATB homeobox 1 | 2.77413 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 2.75832 |
| LOXL1 | lysyl oxidase-like 1 | 2.75742 |
| DIPK1A | divergent protein kinase domain 1A | 2.71262 |
| CHN1 | chimerin 1 | 2.70403 |
| NUP133 | nucleoporin 133kDa | 2.63157 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.59265 |
| NOSIP | nitric oxide synthase interacting protein | 2.50459 |
| NUCB2 | nucleobindin 2 | 2.47162 |
| MIMS2 | mitochondrial inner membrane scaffold 2 | 2.46932 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.45599 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.44983 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 2.43949 |
| CNTFR | ciliary neurotrophic factor receptor | 2.43433 |
| EVL | Enah/Vasp-like | 2.37016 |
| STK10 | serine/threonine kinase 10 | 2.35416 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | 2.32069 |
| UNKL | unkempt family zinc finger-like | 2.2889 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.27212 |
| ERAL1 | Era-like 12S mitochondrial rRNA chaperone 1 | 2.26149 |
| CDX1 | caudal type homeobox 1 | 2.21723 |
| CASP6 | caspase 6, apoptosis-related cysteine peptidase | 2.21175 |
| IDE | insulin-degrading enzyme | 2.19309 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 2.18486 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 2.17745 |
| TOPORS | topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase | 2.17038 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | 2.1703 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.16549 |
| PLSCR3 | phospholipid scramblase 3 | 2.15332 |
| BCORL1 | BCL6 corepressor-like 1 | 2.1492 |
| CNN2 | calponin 2 | 2.13775 |
| MMP13 | matrix metallopeptidase 13 | 2.11814 |
| RRAGA | Ras-related GTP binding A | 2.09184 |
| DMAP1 | DNA methyltransferase 1 associated protein 1 | 2.06107 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 2.05504 |
| BDKRB2 | bradykinin receptor B2 | 2.039 |
| POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | 2.03457 |
| BFSP2 | beaded filament structural protein 2, phakinin | 2.02347 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | 2.02073 |
| IBSP | integrin-binding sialoprotein | 2.01942 |
| CCL24 | chemokine (C-C motif) ligand 24 | 2.00292 |
| EFNA3 | ephrin-A3 | 2.00075 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GNAS | GNAS complex locus | -7.64528 |
| CD320 | CD320 molecule | -6.96484 |
| NGRN | neugrin, neurite outgrowth associated | -6.58753 |
| TLR4 | toll-like receptor 4 | -5.91189 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -5.33694 |
| PCNA | proliferating cell nuclear antigen | -5.13558 |
| LDHD | lactate dehydrogenase D | -5.07138 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -5.05254 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -5.0 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -4.76475 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.71225 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.6025 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.53104 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -4.37042 |
| CCNB1 | cyclin B1 | -4.02162 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.90364 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | -3.68421 |
| ANKRD10 | ankyrin repeat domain 10 | -3.44363 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.21063 |
| ADI1 | acireductone dioxygenase 1 | -3.13581 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.99604 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.99012 |
| GPR19 | G protein-coupled receptor 19 | -2.92733 |
| SLC35F2 | solute carrier family 35, member F2 | -2.82401 |
| RPS5 | ribosomal protein S5 | -2.69462 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.64797 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -2.61701 |
| EML3 | echinoderm microtubule associated protein like 3 | -2.6004 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -2.5937 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.58808 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.5727 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.56674 |
| TCTN1 | tectonic family member 1 | -2.54666 |
| MOCS3 | molybdenum cofactor synthesis 3 | -2.52126 |
| RBM15 | RNA binding motif protein 15 | -2.50815 |
| KLRC4-KLRK1 | KLRC4-KLRK1 readthrough | -2.50372 |
| IFT52 | intraflagellar transport 52 | -2.44913 |
| ATF5 | activating transcription factor 5 | -2.383 |
| KRT4 | keratin 4, type II | -2.3629 |
| ABHD17A | abhydrolase domain containing 17A | -2.36214 |
| RPS15A | ribosomal protein S15a | -2.35923 |
| MVD | mevalonate (diphospho) decarboxylase | -2.32659 |
| DNM1L | dynamin 1-like | -2.30584 |
| S100A10 | S100 calcium binding protein A10 | -2.28228 |
| GNLY | granulysin | -2.27184 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.25624 |
| TMEM255A | transmembrane protein 255A | -2.25613 |
| LYPD1 | LY6/PLAUR domain containing 1 | -2.24439 |
| SSR4 | signal sequence receptor, delta | -2.22406 |
| TERT | telomerase reverse transcriptase | -2.21679 |
| NCKAP1 | NCK-associated protein 1 | -2.20981 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | -2.19115 |
| SLC9A8 | solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 | -2.18757 |
| HOXA5 | homeobox A5 | -2.18246 |
| NXT2 | nuclear transport factor 2-like export factor 2 | -2.18041 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | -2.17604 |
| CHST10 | carbohydrate sulfotransferase 10 | -2.17492 |
| HAT1 | histone acetyltransferase 1 | -2.15383 |
| SLC5A4 | solute carrier family 5 (glucose activated ion channel), member 4 | -2.13837 |
| PRAF2 | PRA1 domain family, member 2 | -2.13779 |
| POGLUT1 | protein O-glucosyltransferase 1 | -2.13344 |
| TAGLN2 | transgelin 2 | -2.1328 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -2.12711 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -2.11132 |
| SCG3 | secretogranin III | -2.10127 |
| EIF3CL | eukaryotic translation initiation factor 3, subunit C-like | -2.08568 |
| RPL18 | ribosomal protein L18 | -2.07524 |
| CLDN16 | claudin 16 | -2.06279 |
| ITM2B | integral membrane protein 2B | -2.06129 |
| HMG20B | high mobility group 20B | -2.05342 |
| RPL36A | ribosomal protein L36a | -2.04243 |
| SHMT1 | serine hydroxymethyltransferase 1 (soluble) | -2.04118 |
| TMOD1 | tropomodulin 1 | -2.02798 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | -2.02418 |
| FAM163A | family with sequence similarity 163, member A | -2.01857 |
| SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae) | -2.01499 |
