CRCGN009_HEPG2_24H:J04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 2.59 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN009_HEPG2_24H:J04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
UBQLN2 ubiquilin 2 7.79871
RPL39L ribosomal protein L39-like 6.93961
CYCS cytochrome c, somatic 6.0928
MAP7 microtubule-associated protein 7 5.64525
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.7704
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.43544
CCL2 chemokine (C-C motif) ligand 2 4.41184
ANO1 anoctamin 1, calcium activated chloride channel 3.59585
ADAM10 ADAM metallopeptidase domain 10 3.1449
PPARG peroxisome proliferator-activated receptor gamma 3.0352
UBE2A ubiquitin-conjugating enzyme E2A 2.90334
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.90151
NOTCH1 notch 1 2.78649
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.76415
SOCS2 suppressor of cytokine signaling 2 2.58859
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.57862
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.43903
CDC73 cell division cycle 73 2.31219
DYNLT3 dynein, light chain, Tctex-type 3 2.28483
RPAP3 RNA polymerase II associated protein 3 2.22517
CALB1 calbindin 1, 28kDa 2.22473
PFKL phosphofructokinase, liver 2.21252
KLC3 kinesin light chain 3 2.20148
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.18176
GRAMD4 GRAM domain containing 4 2.1795
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.13595
CENPX centromere protein X 2.11055
AP1AR adaptor-related protein complex 1 associated regulatory protein 2.07669
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.06458
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.06376
TRA2B transformer 2 beta homolog (Drosophila) 2.06048
BCCIP BRCA2 and CDKN1A interacting protein 2.05278
PTBP3 polypyrimidine tract binding protein 3 2.04855
WDR45B WD repeat domain 45B 2.02434
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2.01254

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.69164
LDHD lactate dehydrogenase D -7.13737
TLR4 toll-like receptor 4 -6.49898
CCNB2 cyclin B2 -5.83006
GNAS GNAS complex locus -5.74687
OXA1L oxidase (cytochrome c) assembly 1-like -5.6539
KDM3A lysine (K)-specific demethylase 3A -4.96501
TSPAN4 tetraspanin 4 -4.68116
MRPS2 mitochondrial ribosomal protein S2 -4.62254
CAB39 calcium binding protein 39 -4.22332
NRIP1 nuclear receptor interacting protein 1 -4.00553
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.709
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.66949
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.54865
RNF167 ring finger protein 167 -3.31519
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.20739
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.93714
HLA-DMA major histocompatibility complex, class II, DM alpha -2.93579
ZDHHC6 zinc finger, DHHC-type containing 6 -2.85807
WASHC4 WASH complex subunit 4 -2.79704
PECR peroxisomal trans-2-enoyl-CoA reductase -2.78448
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.76596
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.75572
SULT4A1 sulfotransferase family 4A, member 1 -2.6246
HPS6 Hermansky-Pudlak syndrome 6 -2.61954
TKT transketolase -2.58652
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.49448
CHMP4B charged multivesicular body protein 4B -2.49334
FBXL12 F-box and leucine-rich repeat protein 12 -2.4624
RPL38 ribosomal protein L38 -2.43892
TXNDC9 thioredoxin domain containing 9 -2.43291
SNX11 sorting nexin 11 -2.40894
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.3643
LGI1 leucine-rich, glioma inactivated 1 -2.34822
UGDH UDP-glucose 6-dehydrogenase -2.33358
GDF15 growth differentiation factor 15 -2.333
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.33105
PCNA proliferating cell nuclear antigen -2.31298
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.26707
UBE3C ubiquitin protein ligase E3C -2.26452
RPL29 ribosomal protein L29 -2.2484
RPL18A ribosomal protein L18a -2.21913
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -2.21677
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.21245
PHB2 prohibitin 2 -2.20704
POU3F2 POU class 3 homeobox 2 -2.20362
POLL polymerase (DNA directed), lambda -2.19884
RPP30 ribonuclease P/MRP 30kDa subunit -2.155
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.13958
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.12803
YME1L1 YME1-like 1 ATPase -2.12461
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.11182
TUBA1C tubulin, alpha 1c -2.10808
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.07897
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.0785
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.06388
BORCS8 BLOC-1 related complex subunit 8 -2.04117
PEX11B peroxisomal biogenesis factor 11 beta -2.04022
SSR4 signal sequence receptor, delta -2.01844
CTSD cathepsin D -2.00354