CRCGN009_HEPG2_24H:J08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimpylate 10.45 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN009_HEPG2_24H:J08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.47666
MYLK myosin light chain kinase 5.24737
AMDHD2 amidohydrolase domain containing 2 4.88314
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.59032
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.45697
TIAM1 T-cell lymphoma invasion and metastasis 1 4.38423
ANO1 anoctamin 1, calcium activated chloride channel 4.19702
MOK MOK protein kinase 3.82829
EVL Enah/Vasp-like 3.64769
RAB4A RAB4A, member RAS oncogene family 3.61883
BZW2 basic leucine zipper and W2 domains 2 3.55546
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.55411
NOTCH1 notch 1 3.21645
ZNF589 zinc finger protein 589 2.80874
LOC122526780 uncharacterized LOC122526780 2.5538
CCDC85B coiled-coil domain containing 85B 2.45697
CDPF1 cysteine-rich, DPF motif domain containing 1 2.37574
WDR7 WD repeat domain 7 2.37385
TNIP1 TNFAIP3 interacting protein 1 2.32419
CYB561 cytochrome b561 2.22656
PMM2 phosphomannomutase 2 2.19365
NOSIP nitric oxide synthase interacting protein 2.15184
CROT carnitine O-octanoyltransferase 2.10274
PEX11A peroxisomal biogenesis factor 11 alpha 2.0934

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -5.29123
CCNB2 cyclin B2 -5.09186
NISCH nischarin -4.9724
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.90466
SLC35F2 solute carrier family 35, member F2 -3.96489
FBXL12 F-box and leucine-rich repeat protein 12 -3.36693
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.18241
SNX11 sorting nexin 11 -3.1794
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.97401
PROS1 protein S (alpha) -2.94035
WASHC4 WASH complex subunit 4 -2.90348
OXA1L oxidase (cytochrome c) assembly 1-like -2.89111
TRIB3 tribbles pseudokinase 3 -2.73501
CRELD2 cysteine-rich with EGF-like domains 2 -2.70612
MAPK13 mitogen-activated protein kinase 13 -2.45833
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.28345
OSGIN2 oxidative stress induced growth inhibitor family member 2 -2.00839