CRCGN009_HEPG2_24H:J09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimpylate 5.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN009_HEPG2_24H:J09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 6.64851
CYCS cytochrome c, somatic 5.71357
MAP7 microtubule-associated protein 7 5.56916
PLSCR1 phospholipid scramblase 1 4.17244
PPARG peroxisome proliferator-activated receptor gamma 3.77898
MYLK myosin light chain kinase 3.71287
HLA-DMA major histocompatibility complex, class II, DM alpha 3.15524
ZFP36 ZFP36 ring finger protein 2.67425
ANO1 anoctamin 1, calcium activated chloride channel 2.61101
DIPK1A divergent protein kinase domain 1A 2.58295
EPN2 epsin 2 2.47949
ABHD6 abhydrolase domain containing 6 2.47836
PLSCR3 phospholipid scramblase 3 2.40642
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.32292
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.14803
VAV3 vav 3 guanine nucleotide exchange factor 2.06394

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
VAT1 vesicle amine transport 1 -6.89985
GNAS GNAS complex locus -5.14578
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.26349
GOLT1B golgi transport 1B -3.79225
BLCAP bladder cancer associated protein -3.78377
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.6228
LDHD lactate dehydrogenase D -3.34444
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.26754
ADI1 acireductone dioxygenase 1 -3.12437
NVL nuclear VCP-like -3.12004
ZMIZ1 zinc finger, MIZ-type containing 1 -2.73942
CCNB2 cyclin B2 -2.73041
NGRN neugrin, neurite outgrowth associated -2.6517
TLR4 toll-like receptor 4 -2.56352
RGS2 regulator of G-protein signaling 2 -2.41543
SCAND1 SCAN domain containing 1 -2.35366
PDZD2 PDZ domain containing 2 -2.33693
PCNA proliferating cell nuclear antigen -2.27855
GLOD4 glyoxalase domain containing 4 -2.01434