CRCGN009_HEPG2_24H:J11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimpylate 1.31 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN009_HEPG2_24H:J11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 5.756
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.18611
EAPP E2F-associated phosphoprotein 4.54716
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.17013
AMDHD2 amidohydrolase domain containing 2 4.127
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.02095
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.8299
ZFP36 ZFP36 ring finger protein 3.7719
LAGE3 L antigen family, member 3 3.73124
STK10 serine/threonine kinase 10 3.72201
UBQLN2 ubiquilin 2 3.68376
BLMH bleomycin hydrolase 3.48839
MAMLD1 mastermind-like domain containing 1 3.42007
CCNF cyclin F 3.38594
VGLL4 vestigial-like family member 4 3.27061
NOSIP nitric oxide synthase interacting protein 3.11795
MAP7 microtubule-associated protein 7 2.81988
GPATCH8 G patch domain containing 8 2.38991
LCN2 lipocalin 2 2.28402
E2F2 E2F transcription factor 2 2.27109
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.21642
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.13167
STXBP2 syntaxin binding protein 2 2.11854
AAMP angio-associated, migratory cell protein 2.11757
BAX BCL2-associated X protein 2.07116
TBPL1 TBP-like 1 2.06002
PEX11A peroxisomal biogenesis factor 11 alpha 2.05861
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.04865
GLRX5 glutaredoxin 5 2.00231

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.35707
PCNA proliferating cell nuclear antigen -5.82758
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.39068
SLC35F2 solute carrier family 35, member F2 -4.33996
VAT1 vesicle amine transport 1 -4.26761
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.23598
KDM3A lysine (K)-specific demethylase 3A -4.21414
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.95962
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.66078
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.6306
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.3854
HEATR1 HEAT repeat containing 1 -3.14259
YME1L1 YME1-like 1 ATPase -3.05004
CSK c-src tyrosine kinase -2.94304
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.66534
NGRN neugrin, neurite outgrowth associated -2.63826
GNAS GNAS complex locus -2.5528
MAPK13 mitogen-activated protein kinase 13 -2.5344
SCAND1 SCAN domain containing 1 -2.50339
CDC25B cell division cycle 25B -2.43572
GTPBP8 GTP-binding protein 8 (putative) -2.42136
BLCAP bladder cancer associated protein -2.23699
RNF167 ring finger protein 167 -2.19309
SNX11 sorting nexin 11 -2.1841
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -2.14062
MAP1S microtubule-associated protein 1S -2.11001