CRCGN009_HEPG2_24H:J13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN009_HEPG2_24H:J13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 6.11684
LSR lipolysis stimulated lipoprotein receptor 5.63034
TATDN2 TatD DNase domain containing 2 5.24623
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.15602
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.94126
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.93762
PPARG peroxisome proliferator-activated receptor gamma 4.83611
CCL2 chemokine (C-C motif) ligand 2 4.57222
CXCR4 chemokine (C-X-C motif) receptor 4 4.30857
FAM20B family with sequence similarity 20, member B 4.1914
PRKCH protein kinase C, eta 3.54372
HEBP1 heme binding protein 1 3.52327
CHN1 chimerin 1 3.28592
VAV3 vav 3 guanine nucleotide exchange factor 3.01049
CDPF1 cysteine-rich, DPF motif domain containing 1 2.99652
NOSIP nitric oxide synthase interacting protein 2.75368
STXBP2 syntaxin binding protein 2 2.52858
DIPK1A divergent protein kinase domain 1A 2.50553
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.43164
ABHD6 abhydrolase domain containing 6 2.4242
PCDHB11 protocadherin beta 11 2.41873
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 2.39351
TOR1AIP2 torsin A interacting protein 2 2.39257
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.36695
GPATCH8 G patch domain containing 8 2.35507
PXMP2 peroxisomal membrane protein 2, 22kDa 2.35389
UFM1 ubiquitin-fold modifier 1 2.34564
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.32856
PMM2 phosphomannomutase 2 2.31811
CTTN cortactin 2.30705
CKAP2 cytoskeleton associated protein 2 2.23
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 2.19852
ANKRD17 ankyrin repeat domain 17 2.16657
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.15777
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.13446
GSTZ1 glutathione S-transferase zeta 1 2.1173
KIF20A kinesin family member 20A 2.10602
WDR43 WD repeat domain 43 2.07738
ECEL1 endothelin converting enzyme-like 1 2.04742
RIC8B RIC8 guanine nucleotide exchange factor B 2.04662
ICAM1 intercellular adhesion molecule 1 2.03736
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.0248
COPZ1 coatomer protein complex, subunit zeta 1 2.02418
SPC25 SPC25, NDC80 kinetochore complex component 2.00514

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -8.56061
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.5505
CCNB2 cyclin B2 -7.02548
PCNA proliferating cell nuclear antigen -6.16209
ZMIZ1 zinc finger, MIZ-type containing 1 -5.89926
OXA1L oxidase (cytochrome c) assembly 1-like -5.47399
C2CD5 C2 calcium-dependent domain containing 5 -5.22459
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.07439
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.82254
CHMP4B charged multivesicular body protein 4B -4.75915
NT5DC2 5'-nucleotidase domain containing 2 -4.75466
CDC20 cell division cycle 20 -4.71411
KDM3A lysine (K)-specific demethylase 3A -4.63242
LOC124907782 dual specificity protein phosphatase 22 -4.59632
CTSD cathepsin D -4.40688
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.38793
CD58 CD58 molecule -4.31876
TLCD3A TLC domain containing 3A -4.02284
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.59757
GNAS GNAS complex locus -3.47755
CTNND1 catenin (cadherin-associated protein), delta 1 -3.34817
MAPK13 mitogen-activated protein kinase 13 -3.22745
CDC25B cell division cycle 25B -2.92882
ZW10 zw10 kinetochore protein -2.9065
WASHC4 WASH complex subunit 4 -2.88809
PEG10 paternally expressed 10 -2.64955
PRPF4 pre-mRNA processing factor 4 -2.40376
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.39549
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.39546
RFC2 replication factor C (activator 1) 2, 40kDa -2.38122
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -2.20838
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.18474
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.12771
ARMCX1 armadillo repeat containing, X-linked 1 -2.10082
PLEKHA5 pleckstrin homology domain containing, family A member 5 -2.10078
BCL2L2 BCL2-like 2 -2.08373
GOLGA8A golgin A8 family, member A -2.07439
SNX11 sorting nexin 11 -2.0736
PLSCR4 phospholipid scramblase 4 -2.02501
TGFB3 transforming growth factor, beta 3 -2.02408