CRCGN009_HEPG2_24H:J14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN009_HEPG2_24H:J14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FZD7 frizzled class receptor 7 4.88531
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.89018
UBQLN2 ubiquilin 2 3.86693
LPAR2 lysophosphatidic acid receptor 2 3.70639
CIAO3 cytosolic iron-sulfur assembly component 3 3.66922
RPL39L ribosomal protein L39-like 3.63231
AMDHD2 amidohydrolase domain containing 2 3.57906
LCN2 lipocalin 2 3.57302
PPARG peroxisome proliferator-activated receptor gamma 3.39633
SQOR sulfide quinone oxidoreductase 3.19318
HOXA10 homeobox A10 2.84807
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.79851
HEBP1 heme binding protein 1 2.49071
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.23418
GOLT1B golgi transport 1B 2.08561
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.07804
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.05374
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.03308
S100A8 S100 calcium binding protein A8 2.01685
MVD mevalonate (diphospho) decarboxylase 2.0128

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -7.3922
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.77745
CCNB2 cyclin B2 -4.58805
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.14457
CCDC86 coiled-coil domain containing 86 -4.12455
DNM1L dynamin 1-like -3.87506
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.77302
OXA1L oxidase (cytochrome c) assembly 1-like -3.63124
GDF15 growth differentiation factor 15 -3.57302
CAB39 calcium binding protein 39 -3.54383
CDC25B cell division cycle 25B -3.52461
SLC35F2 solute carrier family 35, member F2 -2.96497
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.80002
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.75694
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.61148
TLR4 toll-like receptor 4 -2.37788
NRIP1 nuclear receptor interacting protein 1 -2.34268
COG2 component of oligomeric golgi complex 2 -2.32088
GNAS GNAS complex locus -2.3142
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.24634
HSPA8 heat shock 70kDa protein 8 -2.16965
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.11473
TSKU tsukushi, small leucine rich proteoglycan -2.10639
EGF epidermal growth factor -2.07502
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.06353