CRCGN009_HEPG2_24H:J15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN009_HEPG2_24H:J15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 7.10184
CIAO3 cytosolic iron-sulfur assembly component 3 6.24702
CYCS cytochrome c, somatic 4.95618
BACE2 beta-site APP-cleaving enzyme 2 4.33375
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.26545
EVL Enah/Vasp-like 4.05121
TBXA2R thromboxane A2 receptor 3.87964
LCN2 lipocalin 2 3.80638
ANO1 anoctamin 1, calcium activated chloride channel 3.78129
HOXA10 homeobox A10 3.7696
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.69678
AMDHD2 amidohydrolase domain containing 2 3.64404
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.53694
MAST2 microtubule associated serine/threonine kinase 2 3.52116
PPARG peroxisome proliferator-activated receptor gamma 3.46397
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.46269
MCM3 minichromosome maintenance complex component 3 3.42923
GARRE1 granule associated Rac and RHOG effector 1 3.42915
PNKP polynucleotide kinase 3'-phosphatase 3.34703
LYN LYN proto-oncogene, Src family tyrosine kinase 3.22696
CCL2 chemokine (C-C motif) ligand 2 3.16427
MEF2C myocyte enhancer factor 2C 3.07864
UBQLN2 ubiquilin 2 3.04668
PFKL phosphofructokinase, liver 3.02698
STIMATE STIM activating enhancer 3.01187
LOC122526780 uncharacterized LOC122526780 2.97148
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.95377
HDGFL3 HDGF like 3 2.90516
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.80368
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.53742
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.50112
RAB31 RAB31, member RAS oncogene family 2.37118
MAP7 microtubule-associated protein 7 2.36959
JADE2 jade family PHD finger 2 2.35508
TGFB3 transforming growth factor, beta 3 2.28969
CCNF cyclin F 2.27768
STK10 serine/threonine kinase 10 2.26675
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.21495
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.19457
ABHD6 abhydrolase domain containing 6 2.19287
CCNA1 cyclin A1 2.16822
TBP TATA box binding protein 2.16426
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.1569
RENBP renin binding protein 2.14996
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.09906
PYGM phosphorylase, glycogen, muscle 2.0665
KDM5A lysine (K)-specific demethylase 5A 2.05677
BEND5 BEN domain containing 5 2.04803
GATA3 GATA binding protein 3 2.02812
RWDD2B RWD domain containing 2B 2.00736

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -8.17338
MAPK13 mitogen-activated protein kinase 13 -7.64301
LDHD lactate dehydrogenase D -6.4211
KDM3A lysine (K)-specific demethylase 3A -6.38598
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.17922
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.30475
CD58 CD58 molecule -4.60574
TLCD3A TLC domain containing 3A -4.32337
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.32112
UBE3C ubiquitin protein ligase E3C -4.00022
HMG20B high mobility group 20B -3.87354
DSG2 desmoglein 2 -3.80332
BLCAP bladder cancer associated protein -3.53158
ZMIZ1 zinc finger, MIZ-type containing 1 -3.3613
PCNA proliferating cell nuclear antigen -3.34808
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.13871
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.12801
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.0577
ADI1 acireductone dioxygenase 1 -2.98638
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.89375
TM9SF3 transmembrane 9 superfamily member 3 -2.80955
ITGB1BP1 integrin beta 1 binding protein 1 -2.7995
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.79695
ACAA1 acetyl-CoA acyltransferase 1 -2.64198
NT5DC2 5'-nucleotidase domain containing 2 -2.63826
NISCH nischarin -2.59744
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.56482
EGF epidermal growth factor -2.45804
MTX2 metaxin 2 -2.33735
WASHC4 WASH complex subunit 4 -2.27525
TLR4 toll-like receptor 4 -2.17406
GNAS GNAS complex locus -2.16257
OXA1L oxidase (cytochrome c) assembly 1-like -2.16212
CTNND1 catenin (cadherin-associated protein), delta 1 -2.08945
SLC35F2 solute carrier family 35, member F2 -2.0837
EXT1 exostosin glycosyltransferase 1 -2.05589
CCNB2 cyclin B2 -2.05156
SHTN1 shootin 1 -2.02492