CRCGN009_HEPG2_24H:J17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN009_HEPG2_24H:J17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 9.2273
LCN2 lipocalin 2 7.31805
TIAM1 T-cell lymphoma invasion and metastasis 1 5.65757
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.73281
TAC4 tachykinin 4 (hemokinin) 4.56505
RPL39L ribosomal protein L39-like 4.55133
BZW2 basic leucine zipper and W2 domains 2 4.50647
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.45914
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.1749
BACE2 beta-site APP-cleaving enzyme 2 4.15425
CHMP6 charged multivesicular body protein 6 4.13892
UBQLN2 ubiquilin 2 4.02982
MAP7 microtubule-associated protein 7 3.57708
CCL2 chemokine (C-C motif) ligand 2 3.56215
CBR3 carbonyl reductase 3 3.54558
CXCR4 chemokine (C-X-C motif) receptor 4 3.54344
ADRB2 adrenoceptor beta 2, surface 3.4931
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.21122
GPER1 G protein-coupled estrogen receptor 1 3.07596
RAB21 RAB21, member RAS oncogene family 2.86127
CORO1A coronin, actin binding protein, 1A 2.77573
CHN1 chimerin 1 2.72387
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.52201
OLFML2A olfactomedin-like 2A 2.50687
CRTAP cartilage associated protein 2.35581
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.3283
TSPAN6 tetraspanin 6 2.3115
RPA3 replication protein A3, 14kDa 2.28923
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.18362
SFTPB surfactant protein B 2.16688
IQGAP1 IQ motif containing GTPase activating protein 1 2.10084
FXYD1 FXYD domain containing ion transport regulator 1 2.06691
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.01347
TBXA2R thromboxane A2 receptor 2.00873

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.10662
TRIB3 tribbles pseudokinase 3 -5.16567
LDHD lactate dehydrogenase D -4.76585
TUBB6 tubulin, beta 6 class V -4.71686
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.41101
MRPS2 mitochondrial ribosomal protein S2 -4.37503
LOC124907782 dual specificity protein phosphatase 22 -4.30208
RPIA ribose 5-phosphate isomerase A -4.19981
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.95914
PCCB propionyl CoA carboxylase, beta polypeptide -3.95214
MAPK13 mitogen-activated protein kinase 13 -3.8835
NGRN neugrin, neurite outgrowth associated -3.86255
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.85672
CCNB2 cyclin B2 -3.80649
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.28653
SNX11 sorting nexin 11 -2.53884
PLA2G15 phospholipase A2, group XV -2.21405
PRELID3A PRELI domain containing 3A -2.10342
TCEAL4 transcription elongation factor A (SII)-like 4 -2.01464
TIPRL TOR signaling pathway regulator -2.00588