CRCGN009_HEPG2_24H:J19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)benzenesulfonate 20.68 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

45 genes differentially expressed following the CRCGN009_HEPG2_24H:J19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.17303
ADGRE5 adhesion G protein-coupled receptor E5 5.74186
GRWD1 glutamate-rich WD repeat containing 1 5.02754
CYCS cytochrome c, somatic 4.85441
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.83673
NOTCH1 notch 1 4.81575
PEX11A peroxisomal biogenesis factor 11 alpha 4.52744
CCL2 chemokine (C-C motif) ligand 2 4.49568
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.135
ZBTB35 zinc finger and BTB domain containing 35 3.57544
FZD7 frizzled class receptor 7 3.52888
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.66449
MEST mesoderm specific transcript 2.60606
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.52018
IQGAP2 IQ motif containing GTPase activating protein 2 2.42324
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.31483
LOC122526780 uncharacterized LOC122526780 2.30681
MAP7 microtubule-associated protein 7 2.25929
RPA3 replication protein A3, 14kDa 2.19692
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.15953
TBC1D10C TBC1 domain family, member 10C 2.09039
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.0509

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -7.03373
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.99397
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.7829
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.65646
HYOU1 hypoxia up-regulated 1 -4.11408
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.36751
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.26568
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.14691
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.81622
UBE3C ubiquitin protein ligase E3C -2.736
XPO7 exportin 7 -2.37433
RGS2 regulator of G-protein signaling 2 -2.37053
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.35271
TBX2 T-box 2 -2.31909
MAD2L1BP MAD2L1 binding protein -2.30547
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.26282
PTK7 protein tyrosine kinase 7 (inactive) -2.15951
TLE6 transducin-like enhancer of split 6 -2.15141
DLX6 distal-less homeobox 6 -2.13544
EMD emerin -2.09474
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.082
DCK deoxycytidine kinase -2.06599
ARSA arylsulfatase A -2.00457