| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)benzenesulfonate 10.34 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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55 genes differentially expressed following the CRCGN009_HEPG2_24H:J20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | 5.40448 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5.01614 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 4.27777 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 4.12502 |
| CCNA1 | cyclin A1 | 4.11734 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 4.11703 |
| ATP11B | ATPase, class VI, type 11B | 4.1139 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.9362 |
| STAP2 | signal transducing adaptor family member 2 | 3.8818 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.84452 |
| UBQLN2 | ubiquilin 2 | 3.74939 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 3.61161 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 3.50945 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 3.10001 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 3.09284 |
| TEX10 | testis expressed 10 | 3.00106 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.9077 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.87342 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.83735 |
| LCN2 | lipocalin 2 | 2.79929 |
| HEBP1 | heme binding protein 1 | 2.64821 |
| KIFBP | kinesin family binding protein | 2.45166 |
| ADRB2 | adrenoceptor beta 2, surface | 2.25321 |
| H2BC12 | H2B clustered histone 12 | 2.2196 |
| PTK2 | protein tyrosine kinase 2 | 2.20144 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 2.17878 |
| NANS | N-acetylneuraminic acid synthase | 2.17505 |
| NDUFB6 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa | 2.09961 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | 2.09886 |
| TESK1 | testis-specific kinase 1 | 2.05684 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -6.91076 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -6.7075 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.62301 |
| FASTKD5 | FAST kinase domains 5 | -4.76079 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -4.03555 |
| CHMP4B | charged multivesicular body protein 4B | -3.73809 |
| FHL2 | four and a half LIM domains 2 | -3.73437 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.46266 |
| HEATR1 | HEAT repeat containing 1 | -3.21925 |
| ZNF586 | zinc finger protein 586 | -2.98205 |
| CDC20 | cell division cycle 20 | -2.69937 |
| VDAC1 | voltage-dependent anion channel 1 | -2.68449 |
| PCNA | proliferating cell nuclear antigen | -2.55193 |
| TOR1A | torsin family 1, member A (torsin A) | -2.52714 |
| SNX11 | sorting nexin 11 | -2.51408 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -2.47473 |
| MYL9 | myosin, light chain 9, regulatory | -2.42022 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.3146 |
| PDHX | pyruvate dehydrogenase complex, component X | -2.28885 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -2.26781 |
| RGS2 | regulator of G-protein signaling 2 | -2.13787 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.1295 |
| TOMM70 | translocase of outer mitochondrial membrane 70 | -2.03301 |
| RBM15B | RNA binding motif protein 15B | -2.0283 |
| STAT5A | signal transducer and activator of transcription 5A | -2.02678 |
