| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)benzenesulfonate 5.17 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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47 genes differentially expressed following the CRCGN009_HEPG2_24H:J21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LCN2 | lipocalin 2 | 7.70128 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 6.18045 |
| RPL39L | ribosomal protein L39-like | 4.70635 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 4.50386 |
| EPHA3 | EPH receptor A3 | 4.39356 |
| ADRB2 | adrenoceptor beta 2, surface | 4.05175 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.91835 |
| FPGS | folylpolyglutamate synthase | 3.58799 |
| E2F2 | E2F transcription factor 2 | 3.55377 |
| PLSCR1 | phospholipid scramblase 1 | 3.55287 |
| KIFBP | kinesin family binding protein | 3.3922 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.22498 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.14225 |
| PNKP | polynucleotide kinase 3'-phosphatase | 3.13605 |
| ABHD6 | abhydrolase domain containing 6 | 2.95585 |
| KDM5A | lysine (K)-specific demethylase 5A | 2.7217 |
| MAP7 | microtubule-associated protein 7 | 2.58175 |
| RXYLT1 | ribitol xylosyltransferase 1 | 2.39911 |
| TPD52L2 | tumor protein D52-like 2 | 2.35439 |
| DIPK1A | divergent protein kinase domain 1A | 2.34929 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.33237 |
| SAA2 | serum amyloid A2 | 2.31722 |
| TBP | TATA box binding protein | 2.31229 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.30493 |
| SHB | Src homology 2 domain containing adaptor protein B | 2.25157 |
| NR0B2 | nuclear receptor subfamily 0, group B, member 2 | 2.15557 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 2.09587 |
| LOC112694756 | uncharaterized LOC112694756 | 2.01294 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADI1 | acireductone dioxygenase 1 | -6.42069 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -6.39928 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -5.77187 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.42792 |
| PEG10 | paternally expressed 10 | -4.20257 |
| CDC20 | cell division cycle 20 | -3.93911 |
| CCNB2 | cyclin B2 | -3.91049 |
| SLC35F2 | solute carrier family 35, member F2 | -3.73702 |
| ISOC1 | isochorismatase domain containing 1 | -3.64 |
| TLCD3A | TLC domain containing 3A | -3.48996 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.93949 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.86979 |
| LDHD | lactate dehydrogenase D | -2.82428 |
| STAMBP | STAM binding protein | -2.77721 |
| ZNF586 | zinc finger protein 586 | -2.67731 |
| GNAS | GNAS complex locus | -2.52121 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.20546 |
| CCNH | cyclin H | -2.19718 |
| GLOD4 | glyoxalase domain containing 4 | -2.16199 |
