CRCGN009_HEPG2_24H:J23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)benzenesulfonate 1.29 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN009_HEPG2_24H:J23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 5.02903
MYLK myosin light chain kinase 5.00661
PPARG peroxisome proliferator-activated receptor gamma 4.8842
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.83192
STK10 serine/threonine kinase 10 4.75423
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.41863
AMDHD2 amidohydrolase domain containing 2 4.30227
GSTZ1 glutathione S-transferase zeta 1 3.97455
STIMATE STIM activating enhancer 3.87289
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.71243
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.70038
PLSCR1 phospholipid scramblase 1 3.31526
MAP7 microtubule-associated protein 7 2.49621
MEST mesoderm specific transcript 2.36951
GPATCH8 G patch domain containing 8 2.33812
COPS7A COP9 signalosome subunit 7A 2.11911
FTO fat mass and obesity associated 2.06724
DIPK1A divergent protein kinase domain 1A 2.00006

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -5.086
NISCH nischarin -5.04045
FAIM Fas apoptotic inhibitory molecule -4.9397
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.87512
CCNB1 cyclin B1 -4.70742
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.41988
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.30732
PCNA proliferating cell nuclear antigen -4.13127
NGRN neugrin, neurite outgrowth associated -4.08637
ACAA1 acetyl-CoA acyltransferase 1 -3.99368
TWF2 twinfilin actin binding protein 2 -3.61673
RFC2 replication factor C (activator 1) 2, 40kDa -3.60138
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.476
GNAS GNAS complex locus -3.27791
SLC35F2 solute carrier family 35, member F2 -3.24517
EGF epidermal growth factor -2.72285
HOXD11 homeobox D11 -2.63902
NRIP1 nuclear receptor interacting protein 1 -2.47377
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.24334
LSM1 LSM1, U6 small nuclear RNA associated -2.22299
TMPRSS15 transmembrane protease, serine 15 -2.12352
HOXD10 homeobox D10 -2.10343
ACTL8 actin-like 8 -2.06825
COXFA4 cytochrome c oxidase associated subunit FA4 -2.00924