CRCGN009_HEPG2_24H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)benzenesulfonate 0.65 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN009_HEPG2_24H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.10884
DYNLT3 dynein, light chain, Tctex-type 3 5.98517
CHMP6 charged multivesicular body protein 6 5.92111
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.81921
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.2101
RPP38 ribonuclease P/MRP 38kDa subunit 4.07861
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.89401
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.86041
GSTZ1 glutathione S-transferase zeta 1 3.48409
LCN2 lipocalin 2 3.45415
PRKCH protein kinase C, eta 3.20483
GPATCH8 G patch domain containing 8 3.20264
ABHD6 abhydrolase domain containing 6 3.19625
FPGS folylpolyglutamate synthase 3.01151
GPER1 G protein-coupled estrogen receptor 1 2.53126
CCNF cyclin F 2.48852
VGLL4 vestigial-like family member 4 2.40579
CDPF1 cysteine-rich, DPF motif domain containing 1 2.361
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.30166
CCL2 chemokine (C-C motif) ligand 2 2.22231
CEP57 centrosomal protein 57kDa 2.21612
JADE2 jade family PHD finger 2 2.09434
PIH1D1 PIH1 domain containing 1 2.07241
TBP TATA box binding protein 2.04969
CHN1 chimerin 1 2.02996

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.13828
ZNF586 zinc finger protein 586 -5.38655
KDM3A lysine (K)-specific demethylase 3A -4.33212
SCAND1 SCAN domain containing 1 -4.33209
NISCH nischarin -3.79248
CDC20 cell division cycle 20 -3.74074
COG2 component of oligomeric golgi complex 2 -3.49521
PRPF4 pre-mRNA processing factor 4 -3.36847
OXA1L oxidase (cytochrome c) assembly 1-like -3.35946
CCNB2 cyclin B2 -3.26108
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.21536
EIF5 eukaryotic translation initiation factor 5 -2.99825
TRIB3 tribbles pseudokinase 3 -2.92158
GNAS GNAS complex locus -2.83565
ZMIZ1 zinc finger, MIZ-type containing 1 -2.60934
STAMBP STAM binding protein -2.56081
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.36122
CCNB1 cyclin B1 -2.34115
DDIT4 DNA-damage-inducible transcript 4 -2.29176
HYOU1 hypoxia up-regulated 1 -2.28733
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.23723
UBE3C ubiquitin protein ligase E3C -2.1512
FBXL12 F-box and leucine-rich repeat protein 12 -2.13464
NRIP1 nuclear receptor interacting protein 1 -2.0734
SNX11 sorting nexin 11 -2.0704