CRCGN009_HEPG2_24H:K03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-cresidine 9.7 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN009_HEPG2_24H:K03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 6.07311
PPARG peroxisome proliferator-activated receptor gamma 5.16342
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.75087
CHMP6 charged multivesicular body protein 6 4.54488
MSRA methionine sulfoxide reductase A 4.42287
ANO1 anoctamin 1, calcium activated chloride channel 4.20744
RPL39L ribosomal protein L39-like 4.17314
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.07497
NOTCH1 notch 1 3.99564
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.80486
SNAP25 synaptosomal-associated protein, 25kDa 3.79447
EVL Enah/Vasp-like 3.53997
STIMATE STIM activating enhancer 3.43005
FCHO1 FCH domain only 1 3.21679
CXCL2 chemokine (C-X-C motif) ligand 2 3.13371
LOC122526780 uncharacterized LOC122526780 2.97296
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.94645
KIF5C kinesin family member 5C 2.91965
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.75958
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.73304
TPD52L2 tumor protein D52-like 2 2.55263
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.40677
CORO1A coronin, actin binding protein, 1A 2.38363
JADE2 jade family PHD finger 2 2.28328
PLSCR3 phospholipid scramblase 3 2.27002
DIPK1A divergent protein kinase domain 1A 2.2383
RANGRF RAN guanine nucleotide release factor 2.17211
GPATCH8 G patch domain containing 8 2.15803
HEBP1 heme binding protein 1 2.13441
ZNF589 zinc finger protein 589 2.06661
CDK19 cyclin-dependent kinase 19 2.06184
ABHD3 abhydrolase domain containing 3 2.01917

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.60193
GTPBP8 GTP-binding protein 8 (putative) -4.83572
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.60873
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.32776
SLC35F2 solute carrier family 35, member F2 -4.29262
TLR4 toll-like receptor 4 -4.23643
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.20422
GNAS GNAS complex locus -4.17456
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.14604
GOLT1B golgi transport 1B -4.12175
PCNA proliferating cell nuclear antigen -4.00939
TES testin LIM domain protein -3.39084
FBXL12 F-box and leucine-rich repeat protein 12 -3.03963
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -3.00248
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.9493
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.59608
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.58174
NGRN neugrin, neurite outgrowth associated -2.46249
CSK c-src tyrosine kinase -2.4148
EGF epidermal growth factor -2.38524
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.37973
RBM15B RNA binding motif protein 15B -2.24237
MNS1 meiosis-specific nuclear structural 1 -2.23058
HMG20B high mobility group 20B -2.20295
CCNH cyclin H -2.16155
TLCD3A TLC domain containing 3A -2.08486
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.057
PPOX protoporphyrinogen oxidase -2.01781
OXA1L oxidase (cytochrome c) assembly 1-like -2.00835