CRCGN009_HEPG2_24H:K11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vorinostat 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

601 genes differentially expressed following the CRCGN009_HEPG2_24H:K11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
UBE2L6 ubiquitin-conjugating enzyme E2L 6 10.0
FOXO4 forkhead box O4 9.87516
DNM1 dynamin 1 9.69587
CBR1 carbonyl reductase 1 9.15394
ALDOC aldolase C, fructose-bisphosphate 8.56462
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 7.58501
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 7.46969
STX1A syntaxin 1A (brain) 7.27072
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 7.04751
GPER1 G protein-coupled estrogen receptor 1 6.76446
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 6.4418
HMG20B high mobility group 20B 6.41079
MVP major vault protein 6.38464
LGMN legumain 6.38093
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 6.32349
LSR lipolysis stimulated lipoprotein receptor 5.84204
CGRRF1 cell growth regulator with ring finger domain 1 5.73945
CARMIL1 capping protein regulator and myosin 1 linker 1 5.71753
H2BC12 H2B clustered histone 12 5.68479
DUSP6 dual specificity phosphatase 6 5.66787
MYC v-myc avian myelocytomatosis viral oncogene homolog 5.54852
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 5.49031
CORO1A coronin, actin binding protein, 1A 5.43726
TCEA2 transcription elongation factor A (SII), 2 5.43213
STXBP1 syntaxin binding protein 1 5.21585
PRKCD protein kinase C, delta 5.11814
PLA2G15 phospholipase A2, group XV 5.0735
SKIC2 SKI2 subunit of superkiller complex 5.0313
TAC4 tachykinin 4 (hemokinin) 4.94546
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.83175
INTS3 integrator complex subunit 3 4.75466
ADGRE5 adhesion G protein-coupled receptor E5 4.70927
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 4.60767
TBC1D10C TBC1 domain family, member 10C 4.59824
ABHD4 abhydrolase domain containing 4 4.5199
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 4.4205
TIMP2 TIMP metallopeptidase inhibitor 2 4.38669
NUCB2 nucleobindin 2 4.3779
ZMIZ1 zinc finger, MIZ-type containing 1 4.28165
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.24147
ADAM10 ADAM metallopeptidase domain 10 4.16826
AMDHD2 amidohydrolase domain containing 2 4.03189
TIAM1 T-cell lymphoma invasion and metastasis 1 3.98808
TRAPPC6A trafficking protein particle complex 6A 3.9129
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.82646
SATB1 SATB homeobox 1 3.77398
TBPL1 TBP-like 1 3.76099
ISG15 ISG15 ubiquitin-like modifier 3.75523
ZDHHC6 zinc finger, DHHC-type containing 6 3.74174
TXNRD1 thioredoxin reductase 1 3.71645
CCP110 centriolar coiled coil protein 110kDa 3.68278
AARS1 alanyl-tRNA synthetase 1 3.63327
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.57831
ARFIP2 ADP-ribosylation factor interacting protein 2 3.56992
STK10 serine/threonine kinase 10 3.56983
IFI6 interferon, alpha-inducible protein 6 3.56914
INPP1 inositol polyphosphate-1-phosphatase 3.5652
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.53947
EPN2 epsin 2 3.53645
NIT1 nitrilase 1 3.53585
CCND3 cyclin D3 3.52423
BAMBI BMP and activin membrane-bound inhibitor 3.51764
GRN granulin 3.5065
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.49682
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.49616
BMP4 bone morphogenetic protein 4 3.47676
FBXO2 F-box protein 2 3.45537
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.45148
ANO10 anoctamin 10 3.40468
ABHD6 abhydrolase domain containing 6 3.32868
BBC3 BCL2 binding component 3 3.3279
LCN2 lipocalin 2 3.31924
RSU1 Ras suppressor protein 1 3.30009
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.29353
IFI44L interferon-induced protein 44-like 3.24379
CHMP6 charged multivesicular body protein 6 3.24268
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.17132
COL21A1 collagen, type XXI, alpha 1 3.14414
TWF2 twinfilin actin binding protein 2 3.09676
HLA-DMA major histocompatibility complex, class II, DM alpha 3.08794
CBR3 carbonyl reductase 3 3.08351
TMEM50A transmembrane protein 50A 3.08022
IFI44 interferon-induced protein 44 3.07555
TM9SF2 transmembrane 9 superfamily member 2 3.07435
ICAM1 intercellular adhesion molecule 1 3.07427
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.06976
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 3.06925
IER3 immediate early response 3 3.06562
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.06258
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 3.04974
COG7 component of oligomeric golgi complex 7 2.95014
LAMA5 laminin, alpha 5 2.94679
MLEC malectin 2.91063
NPDC1 neural proliferation, differentiation and control, 1 2.89908
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.89786
DDB2 damage-specific DNA binding protein 2, 48kDa 2.89577
AKAP8 A kinase (PRKA) anchor protein 8 2.88371
EMCN endomucin 2.87427
H2AC6 H2A clustered histone 6 2.86357
TRIB1 tribbles pseudokinase 1 2.85123
MX1 MX dynamin-like GTPase 1 2.83349
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.82861
UBQLN2 ubiquilin 2 2.8081
RBM12B RNA binding motif protein 12B 2.80808
PRCP prolylcarboxypeptidase (angiotensinase C) 2.79163
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.78419
IFI27 interferon, alpha-inducible protein 27 2.76189
CCDC71 coiled-coil domain containing 71 2.74937
CALM3 calmodulin 3 (phosphorylase kinase, delta) 2.74542
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 2.72744
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.7175
GLRX glutaredoxin (thioltransferase) 2.70629
HMOX1 heme oxygenase 1 2.69377
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.69007
CMTR1 cap methyltransferase 1 2.67714
E2F2 E2F transcription factor 2 2.65209
IQGAP1 IQ motif containing GTPase activating protein 1 2.65152
LOC127933115 uncharacterized LOC127933115 2.64992
EGR1 early growth response 1 2.64932
THSD7A thrombospondin, type I, domain containing 7A 2.64846
PLK2 polo-like kinase 2 2.64438
MAGEH1 melanoma antigen family H1 2.64413
RBKS ribokinase 2.64274
GNB5 guanine nucleotide binding protein (G protein), beta 5 2.63934
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.63214
RIGI RNA sensor RIG-I 2.6311
SNPH syntaphilin 2.63103
UNC93B1 unc-93 homolog B1 (C. elegans) 2.62816
FAT1 FAT atypical cadherin 1 2.61928
NCOA3 nuclear receptor coactivator 3 2.61192
BST2 bone marrow stromal cell antigen 2 2.60723
FCHO1 FCH domain only 1 2.59674
CORO7-PAM16 CORO7-PAM16 readthrough 2.59099
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.57847
TARBP1 TAR (HIV-1) RNA binding protein 1 2.55889
KIAA0319 KIAA0319 2.5531
CNPY4 canopy FGF signaling regulator 4 2.53781
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.53509
AMPD2 adenosine monophosphate deaminase 2 2.53268
SEPHS2 selenophosphate synthetase 2 2.52543
DENND2D DENN/MADD domain containing 2D 2.52062
RSAD2 radical S-adenosyl methionine domain containing 2 2.51432
BACE2 beta-site APP-cleaving enzyme 2 2.51109
GET1 guided entry of tail-anchored proteins factor 1 2.50818
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.49939
SETD1A SET domain containing 1A 2.48941
STXBP2 syntaxin binding protein 2 2.48751
LGALS1 lectin, galactoside-binding, soluble, 1 2.48385
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.46815
ADAR adenosine deaminase, RNA-specific 2.46493
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.46364
DDN dendrin 2.45485
FKBP1B FK506 binding protein 1B, 12.6 kDa 2.45331
ZFC3H1 zinc finger, C3H1-type containing 2.45246
LYN LYN proto-oncogene, Src family tyrosine kinase 2.44635
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 2.44557
ZNF646 zinc finger protein 646 2.43823
IGFBP3 insulin-like growth factor binding protein 3 2.43279
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.43008
GDE1 glycerophosphodiester phosphodiesterase 1 2.42819
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.42123
ACP5 acid phosphatase 5, tartrate resistant 2.4203
EDNRA endothelin receptor type A 2.41757
IRF9 interferon regulatory factor 9 2.41249
PLXND1 plexin D1 2.41098
CCNF cyclin F 2.40757
TCEAL2 transcription elongation factor A (SII)-like 2 2.38872
CRIP2 cysteine-rich protein 2 2.3848
ZFP36 ZFP36 ring finger protein 2.38427
TCF15 transcription factor 15 (basic helix-loop-helix) 2.38147
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.35662
ATG2A autophagy related 2A 2.35376
FAM110D family with sequence similarity 110, member D 2.34501
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 2.3449
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.34403
H2BC5 H2B clustered histone 5 2.34102
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.32768
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.32393
WDR44 WD repeat domain 44 2.31196
H2BC9 H2B clustered histone 9 2.30789
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 2.30767
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.30176
PTK2 protein tyrosine kinase 2 2.29842
DPY19L4 dpy-19-like 4 (C. elegans) 2.29768
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.29383
UGDH UDP-glucose 6-dehydrogenase 2.2905
HDAC7 histone deacetylase 7 2.285
SNAP29 synaptosomal-associated protein, 29kDa 2.2832
MAPK3 mitogen-activated protein kinase 3 2.28167
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.28122
RAB3A RAB3A, member RAS oncogene family 2.27506
CBX6 chromobox homolog 6 2.27437
USP18 ubiquitin specific peptidase 18 2.26109
TRIM5 tripartite motif containing 5 2.25451
UBA7 ubiquitin-like modifier activating enzyme 7 2.25279
CBX7 chromobox homolog 7 2.25225
SIX1 SIX homeobox 1 2.2429
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.23856
PMP22 peripheral myelin protein 22 2.23678
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.23559
ADGRL4 adhesion G protein-coupled receptor L4 2.23532
CALCRL calcitonin receptor-like 2.23396
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.23139
TLE6 transducin-like enhancer of split 6 2.2265
HLA-E major histocompatibility complex, class I, E 2.22265
CYTH1 cytohesin 1 2.2219
H2BC4 H2B clustered histone 4 2.22137
INPP5F inositol polyphosphate-5-phosphatase F 2.22108
FANCF Fanconi anemia, complementation group F 2.21786
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 2.21226
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.20613
ADGRL1 adhesion G protein-coupled receptor L1 2.19728
HABP4 hyaluronan binding protein 4 2.19078
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.18746
GATA2 GATA binding protein 2 2.18167
RND1 Rho family GTPase 1 2.17987
FKBPL FK506 binding protein like 2.17825
GPR137B G protein-coupled receptor 137B 2.17761
APEH acylaminoacyl-peptide hydrolase 2.17674
CYB561 cytochrome b561 2.16973
GPR162 G protein-coupled receptor 162 2.16939
CLTC clathrin, heavy chain (Hc) 2.16597
RUVBL1 RuvB-like AAA ATPase 1 2.16531
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.16395
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 2.16148
TYW2 tRNA wybutosine-synthesizing protein 2 2.15995
H1-2 H1.2 linker histone, cluster member 2.15732
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 2.15548
OGFR opioid growth factor receptor 2.15156
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 2.1496
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.14799
GID8 GID complex subunit 8 2.147
LBR lamin B receptor 2.14566
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.14561
ETV7 ets variant 7 2.14219
COG2 component of oligomeric golgi complex 2 2.13136
UNC13A unc-13 homolog A (C. elegans) 2.12312
MACO1 macoilin 1 2.12105
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 2.12021
QRICH1 glutamine-rich 1 2.12019
RGN regucalcin 2.11908
UCN urocortin 2.10967
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.09829
TBX2 T-box 2 2.0951
SCGN secretagogin, EF-hand calcium binding protein 2.08979
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.08921
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.08886
STX16 syntaxin 16 2.08769
SIN3B SIN3 transcription regulator family member B 2.08473
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.08288
ECE1 endothelin converting enzyme 1 2.08093
SGCE sarcoglycan, epsilon 2.08085
CATSPER2 cation channel, sperm associated 2 2.08078
EFCAB14 EF-hand calcium binding domain 14 2.08074
LEMD3 LEM domain containing 3 2.07612
DYNC2I1 dynein 2 intermediate chain 1 2.07601
SERGEF secretion regulating guanine nucleotide exchange factor 2.07489
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2.07409
SGMS1 sphingomyelin synthase 1 2.07407
MYLIP myosin regulatory light chain interacting protein 2.07212
ROGDI rogdi homolog (Drosophila) 2.07166
CELF3 CUGBP, Elav-like family member 3 2.06896
BIN3 bridging integrator 3 2.06762
CLDN6 claudin 6 2.06711
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.06706
AHR aryl hydrocarbon receptor 2.0666
PDLIM1 PDZ and LIM domain 1 2.05885
MINDY1 MINDY lysine 48 deubiquitinase 1 2.05703
RHOF ras homolog family member F (in filopodia) 2.04855
AKR1C3 aldo-keto reductase family 1, member C3 2.04482
TDRD7 tudor domain containing 7 2.04228
MUTYH mutY homolog 2.03917
TESK2 testis-specific kinase 2 2.03642
GJA4 gap junction protein, alpha 4, 37kDa 2.03472
TMCO1 transmembrane and coiled-coil domains 1 2.03442
ARMCX4 armadillo repeat containing, X-linked 4 2.02692
SLC22A17 solute carrier family 22, member 17 2.02023
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.01732
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.01604
CRYZL1 crystallin, zeta (quinone reductase)-like 1 2.015
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.00637
ADGRD2 adhesion G protein-coupled receptor D2 2.00354
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.00199
USP6NL USP6 N-terminal like 2.00099

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -9.52884
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -8.92093
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -8.49064
FAIM Fas apoptotic inhibitory molecule -8.32936
CD320 CD320 molecule -8.05959
RPIA ribose 5-phosphate isomerase A -7.27329
GLOD4 glyoxalase domain containing 4 -7.19116
FOSL1 FOS-like antigen 1 -7.02666
TCTN1 tectonic family member 1 -6.99013
PLK1 polo-like kinase 1 -6.93224
PCNA proliferating cell nuclear antigen -6.74793
TCERG1 transcription elongation regulator 1 -6.70432
STAP2 signal transducing adaptor family member 2 -6.66166
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -6.53014
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -6.50863
CCNA2 cyclin A2 -6.44147
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.42523
SLC35F2 solute carrier family 35, member F2 -6.42163
KEAP1 kelch-like ECH-associated protein 1 -6.23449
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -6.18402
ZW10 zw10 kinetochore protein -6.18222
TLCD3A TLC domain containing 3A -6.07908
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -6.01457
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -5.98137
TRIB3 tribbles pseudokinase 3 -5.95866
RRAGA Ras-related GTP binding A -5.83963
NUP85 nucleoporin 85kDa -5.81518
ISOC1 isochorismatase domain containing 1 -5.80653
PGM1 phosphoglucomutase 1 -5.74047
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.69833
CCNB1 cyclin B1 -5.64456
PROS1 protein S (alpha) -5.62294
CCNB2 cyclin B2 -5.60423
TATDN2 TatD DNase domain containing 2 -5.51716
CDK1 cyclin-dependent kinase 1 -5.49652
CRELD2 cysteine-rich with EGF-like domains 2 -5.37407
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.36068
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.33683
TMEM109 transmembrane protein 109 -5.21269
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.16828
CHEK1 checkpoint kinase 1 -4.98688
MELK maternal embryonic leucine zipper kinase -4.93796
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -4.90229
SOAT2 sterol O-acyltransferase 2 -4.88819
PUF60 poly-U binding splicing factor 60KDa -4.86989
GTPBP8 GTP-binding protein 8 (putative) -4.85356
UBE2C ubiquitin-conjugating enzyme E2C -4.64585
LOC124907782 dual specificity protein phosphatase 22 -4.62211
SPAG7 sperm associated antigen 7 -4.60223
NNT nicotinamide nucleotide transhydrogenase -4.60073
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -4.44743
FOXM1 forkhead box M1 -4.31075
LRRC41 leucine rich repeat containing 41 -4.28699
SMNDC1 survival motor neuron domain containing 1 -4.18102
TMEM97 transmembrane protein 97 -4.07786
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.07339
SLC35B1 solute carrier family 35, member B1 -4.00745
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.93924
AURKB aurora kinase B -3.91255
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.89948
ECH1 enoyl CoA hydratase 1, peroxisomal -3.89671
DCK deoxycytidine kinase -3.865
TES testin LIM domain protein -3.85993
PCCB propionyl CoA carboxylase, beta polypeptide -3.75031
MYO19 myosin XIX -3.67521
NGRN neugrin, neurite outgrowth associated -3.64678
KLHL21 kelch-like family member 21 -3.64436
HMGA2 high mobility group AT-hook 2 -3.57205
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.54555
MSRA methionine sulfoxide reductase A -3.46671
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.43523
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.42046
SQOR sulfide quinone oxidoreductase -3.41824
ATF5 activating transcription factor 5 -3.40401
DCTD dCMP deaminase -3.4032
ICAM3 intercellular adhesion molecule 3 -3.40251
HYOU1 hypoxia up-regulated 1 -3.38119
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.35974
MYLK myosin light chain kinase -3.35746
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.35171
CDC25A cell division cycle 25A -3.34039
MRPS16 mitochondrial ribosomal protein S16 -3.32459
SPAG4 sperm associated antigen 4 -3.31524
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.31104
GNAS GNAS complex locus -3.29316
ZBTB35 zinc finger and BTB domain containing 35 -3.27923
CDC25B cell division cycle 25B -3.26582
HADH hydroxyacyl-CoA dehydrogenase -3.25831
MRPS2 mitochondrial ribosomal protein S2 -3.2482
KIF11 kinesin family member 11 -3.2132
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.20438
CPNE3 copine III -3.20012
CENPE centromere protein E, 312kDa -3.19254
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.19226
ZNF586 zinc finger protein 586 -3.18618
CDK4 cyclin-dependent kinase 4 -3.18332
CDCA3 cell division cycle associated 3 -3.17172
DERA deoxyribose-phosphate aldolase (putative) -3.16156
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.13809
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -3.12108
PTS 6-pyruvoyltetrahydropterin synthase -3.08926
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 -3.06048
YME1L1 YME1-like 1 ATPase -3.05539
POLE polymerase (DNA directed), epsilon, catalytic subunit -3.0278
MOK MOK protein kinase -3.02373
TUBB6 tubulin, beta 6 class V -2.96429
TERT telomerase reverse transcriptase -2.9525
TFDP1 transcription factor Dp-1 -2.94773
MRPL39 mitochondrial ribosomal protein L39 -2.93588
PHF2 PHD finger protein 2 -2.91644
GPN1 GPN-loop GTPase 1 -2.91048
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.90497
USP22 ubiquitin specific peptidase 22 -2.89441
KIF15 kinesin family member 15 -2.87599
AURKA aurora kinase A -2.87193
TMEM147 transmembrane protein 147 -2.86699
SMC4 structural maintenance of chromosomes 4 -2.8529
BIRC5 baculoviral IAP repeat containing 5 -2.84354
PDCD5 programmed cell death 5 -2.84119
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.83952
ACOT2 acyl-CoA thioesterase 2 -2.81374
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) -2.80767
TRIP13 thyroid hormone receptor interactor 13 -2.7955
FBXO7 F-box protein 7 -2.79469
THOC1 THO complex 1 -2.78505
FANCC Fanconi anemia, complementation group C -2.7811
CDT1 chromatin licensing and DNA replication factor 1 -2.77811
USF2 upstream transcription factor 2, c-fos interacting -2.74188
ITGB5 integrin, beta 5 -2.73875
TIMELESS timeless circadian clock -2.73305
TCEAL4 transcription elongation factor A (SII)-like 4 -2.73197
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.71955
RPH3AL rabphilin 3A-like (without C2 domains) -2.70268
TLR4 toll-like receptor 4 -2.68391
PMM2 phosphomannomutase 2 -2.67613
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.66418
FAM174C family with sequence similarity 174 member C -2.6546
KIF4A kinesin family member 4A -2.63838
CASC3 cancer susceptibility candidate 3 -2.63065
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.62797
TSPAN6 tetraspanin 6 -2.62353
WASHC4 WASH complex subunit 4 -2.62322
CDCA8 cell division cycle associated 8 -2.62133
NENF neudesin neurotrophic factor -2.61487
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -2.61052
PARPBP PARP1 binding protein -2.6024
TROAP trophinin associated protein -2.60162
AVEN apoptosis, caspase activation inhibitor -2.59965
CSK c-src tyrosine kinase -2.58666
STAMBP STAM binding protein -2.58218
VBP1 von Hippel-Lindau binding protein 1 -2.57935
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -2.57649
NUP58 nucleoporin 58 -2.57501
UBA2 ubiquitin-like modifier activating enzyme 2 -2.57016
TTK TTK protein kinase -2.54969
ZNF282 zinc finger protein 282 -2.52326
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.51345
HEBP1 heme binding protein 1 -2.50248
ZNF274 zinc finger protein 274 -2.48753
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.48445
ZBED1 zinc finger, BED-type containing 1 -2.48393
SMAGP small cell adhesion glycoprotein -2.47099
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.46989
ELAC2 elaC ribonuclease Z 2 -2.46933
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.46488
FANCG Fanconi anemia, complementation group G -2.4645
CCNH cyclin H -2.46099
ATP5PF ATP synthase peripheral stalk subunit F6 -2.46086
OXCT1 3-oxoacid CoA transferase 1 -2.45736
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.45372
CRYZ crystallin, zeta (quinone reductase) -2.44061
PHF10 PHD finger protein 10 -2.43581
EXOSC8 exosome component 8 -2.43194
TOP2A topoisomerase (DNA) II alpha 170kDa -2.42841
LYRM1 LYR motif containing 1 -2.42432
NRIP1 nuclear receptor interacting protein 1 -2.4241
HRAS Harvey rat sarcoma viral oncogene homolog -2.42124
RFC3 replication factor C (activator 1) 3, 38kDa -2.41386
LRRC61 leucine rich repeat containing 61 -2.41381
PPARG peroxisome proliferator-activated receptor gamma -2.41312
ATP9B ATPase, class II, type 9B -2.40993
ANXA7 annexin A7 -2.40931
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -2.40535
MRPL19 mitochondrial ribosomal protein L19 -2.40273
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.39783
PARVB parvin, beta -2.39626
YAP1 Yes-associated protein 1 -2.39336
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.39322
POMK protein-O-mannose kinase -2.38884
ZMYND11 zinc finger, MYND-type containing 11 -2.38856
MPDU1 mannose-P-dolichol utilization defect 1 -2.38847
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.38361
TBCB tubulin folding cofactor B -2.37365
BCL7B B-cell CLL/lymphoma 7B -2.37289
MRPL12 mitochondrial ribosomal protein L12 -2.37223
UBXN8 UBX domain protein 8 -2.37146
COA3 cytochrome c oxidase assembly factor 3 -2.36982
GALE UDP-galactose-4-epimerase -2.36944
MTARC1 mitochondrial amidoxime reducing component 1 -2.36495
WTAP Wilms tumor 1 associated protein -2.34948
NUP88 nucleoporin 88kDa -2.34677
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.34295
SKA1 spindle and kinetochore associated complex subunit 1 -2.33443
BIRC2 baculoviral IAP repeat containing 2 -2.3277
FXYD3 FXYD domain containing ion transport regulator 3 -2.31565
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.31108
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.30942
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.3023
ACO1 aconitase 1, soluble -2.30224
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -2.30063
MICALL1 MICAL-like 1 -2.29615
AEBP1 AE binding protein 1 -2.29429
KIF14 kinesin family member 14 -2.29317
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.29063
ELSPBP1 epididymal sperm binding protein 1 -2.28895
NUP62 nucleoporin 62kDa -2.28784
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -2.28657
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -2.2847
MSL1 male-specific lethal 1 homolog (Drosophila) -2.28423
LAGE3 L antigen family, member 3 -2.27691
MCM5 minichromosome maintenance complex component 5 -2.27307
GTSE1 G-2 and S-phase expressed 1 -2.26597
AGMAT agmatine ureohydrolase (agmatinase) -2.26421
NCF4 neutrophil cytosolic factor 4, 40kDa -2.25791
ATP5ME ATP synthase membrane subunit e -2.25785
PMF1-BGLAP PMF1-BGLAP readthrough -2.25482
KRCC1 lysine-rich coiled-coil 1 -2.25382
TSSC4 tumor suppressing subtransferable candidate 4 -2.25086
MCM10 minichromosome maintenance complex component 10 -2.23999
CTSL cathepsin L -2.23594
HJURP Holliday junction recognition protein -2.23425
RAD51AP1 RAD51 associated protein 1 -2.23357
HACD2 3-hydroxyacyl-CoA dehydratase 2 -2.23332
ENOSF1 enolase superfamily member 1 -2.22937
NEK2 NIMA-related kinase 2 -2.22913
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.22411
POLK polymerase (DNA directed) kappa -2.22316
CCDC59 coiled-coil domain containing 59 -2.21895
TTC19 tetratricopeptide repeat domain 19 -2.21492
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.19927
TFCP2L1 transcription factor CP2-like 1 -2.1973
DEPDC1 DEP domain containing 1 -2.19693
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -2.19226
LPAR3 lysophosphatidic acid receptor 3 -2.19183
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.19105
USP9Y ubiquitin specific peptidase 9, Y-linked -2.18626
PXMP2 peroxisomal membrane protein 2, 22kDa -2.17728
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -2.17695
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -2.17618
CEP55 centrosomal protein 55kDa -2.1701
CDC73 cell division cycle 73 -2.15948
SPRR3 small proline-rich protein 3 -2.15763
TEAD4 TEA domain family member 4 -2.15183
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) -2.1496
MRPL3 mitochondrial ribosomal protein L3 -2.1494
RPL3L ribosomal protein L3-like -2.14798
DONSON downstream neighbor of SON -2.13937
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.13878
POM121C POM121 transmembrane nucleoporin C -2.13722
NCAPH non-SMC condensin I complex, subunit H -2.1343
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.13231
DHFR dihydrofolate reductase -2.12982
CLEC5A C-type lectin domain family 5, member A -2.12886
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -2.12797
BARX2 BARX homeobox 2 -2.12785
HOXB9 homeobox B9 -2.12299
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.11759
DNM1L dynamin 1-like -2.11671
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.11576
PFKL phosphofructokinase, liver -2.11515
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -2.1118
ZWINT ZW10 interacting kinetochore protein -2.10836
NCAPG2 non-SMC condensin II complex, subunit G2 -2.10723
TNIP2 TNFAIP3 interacting protein 2 -2.09773
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -2.09393
KLHL11 kelch-like family member 11 -2.08928
CPNE2 copine II -2.08822
LARS2 leucyl-tRNA synthetase 2, mitochondrial -2.08743
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -2.08441
CUL1 cullin 1 -2.0827
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.0826
COPS3 COP9 signalosome subunit 3 -2.07921
IGHMBP2 immunoglobulin mu binding protein 2 -2.07796
PAIP1 poly(A) binding protein interacting protein 1 -2.07471
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.07111
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.06557
ASGR2 asialoglycoprotein receptor 2 -2.06218
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.05995
RHOH ras homolog family member H -2.05975
FLOT2 flotillin 2 -2.05547
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.05496
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.04548
OIP5 Opa interacting protein 5 -2.04518
CCR8 chemokine (C-C motif) receptor 8 -2.04479
C2CD2 C2 calcium-dependent domain containing 2 -2.04446
GRTP1 growth hormone regulated TBC protein 1 -2.0388
IRAK1 interleukin-1 receptor-associated kinase 1 -2.03857
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.03782
KRT13 keratin 13, type I -2.03624
CTDNEP1 CTD nuclear envelope phosphatase 1 -2.03307
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -2.03203
PLA1A phospholipase A1 member A -2.03065
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.03037
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.02365
FST follistatin -2.02351
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.02113
TPM1 tropomyosin 1 (alpha) -2.01591
ZIM2 zinc finger, imprinted 2 -2.01515
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.01264
ATXN10 ataxin 10 -2.01188
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.01147
SCMH1 sex comb on midleg homolog 1 (Drosophila) -2.00792
KIF5B kinesin family member 5B -2.00752
G6PC3 glucose 6 phosphatase, catalytic, 3 -2.00448
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -2.00203