CRCGN009_HEPG2_24H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vorinostat 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

320 genes differentially expressed following the CRCGN009_HEPG2_24H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBE2L6 ubiquitin-conjugating enzyme E2L 6 9.70109
CBR1 carbonyl reductase 1 9.06556
FOXO4 forkhead box O4 8.62135
DNM1 dynamin 1 7.59842
PNKP polynucleotide kinase 3'-phosphatase 6.29874
CDPF1 cysteine-rich, DPF motif domain containing 1 6.29414
MYLK myosin light chain kinase 5.90252
TIMP2 TIMP metallopeptidase inhibitor 2 5.50612
MVP major vault protein 5.44067
TBPL1 TBP-like 1 5.34665
ALDOC aldolase C, fructose-bisphosphate 5.34219
MYC v-myc avian myelocytomatosis viral oncogene homolog 5.20717
LGMN legumain 5.06232
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.05348
PLA2G15 phospholipase A2, group XV 5.00347
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.96456
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.87011
CORO1A coronin, actin binding protein, 1A 4.65568
NUCB2 nucleobindin 2 4.45198
STXBP1 syntaxin binding protein 1 4.44179
DUSP6 dual specificity phosphatase 6 4.35461
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 4.27663
TCEA2 transcription elongation factor A (SII), 2 4.04249
PTPN12 protein tyrosine phosphatase, non-receptor type 12 3.91143
ANO10 anoctamin 10 3.81886
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.81596
CCP110 centriolar coiled coil protein 110kDa 3.79348
ABHD4 abhydrolase domain containing 4 3.77355
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.74588
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.67696
STIMATE STIM activating enhancer 3.66674
CXCL2 chemokine (C-X-C motif) ligand 2 3.66569
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.63367
IER3 immediate early response 3 3.63103
BMP4 bone morphogenetic protein 4 3.61981
SKIC2 SKI2 subunit of superkiller complex 3.59522
DENND2D DENN/MADD domain containing 2D 3.57752
PMM2 phosphomannomutase 2 3.56775
TMEM50A transmembrane protein 50A 3.55237
ADGRG1 adhesion G protein-coupled receptor G1 3.53721
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.48392
CHMP6 charged multivesicular body protein 6 3.43635
STXBP2 syntaxin binding protein 2 3.40642
PRR15L proline rich 15-like 3.39305
STX1A syntaxin 1A (brain) 3.35716
AARS1 alanyl-tRNA synthetase 1 3.33534
ABHD6 abhydrolase domain containing 6 3.3252
VAT1 vesicle amine transport 1 3.28974
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.26787
CYB561 cytochrome b561 3.24259
ARFIP2 ADP-ribosylation factor interacting protein 2 3.22742
TWF2 twinfilin actin binding protein 2 3.20816
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.18624
TUBB6 tubulin, beta 6 class V 3.15567
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 3.14512
NCOA3 nuclear receptor coactivator 3 3.14376
LCN2 lipocalin 2 3.12355
LSR lipolysis stimulated lipoprotein receptor 3.10461
PLS1 plastin 1 3.09913
ICAM1 intercellular adhesion molecule 1 3.08718
TXNRD1 thioredoxin reductase 1 3.06083
NPDC1 neural proliferation, differentiation and control, 1 3.00876
SCYL3 SCY1-like 3 (S. cerevisiae) 2.99458
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.9903
PRCP prolylcarboxypeptidase (angiotensinase C) 2.98071
CGRRF1 cell growth regulator with ring finger domain 1 2.9608
COG7 component of oligomeric golgi complex 7 2.94992
CARMIL1 capping protein regulator and myosin 1 linker 1 2.92741
TRAPPC6A trafficking protein particle complex 6A 2.91609
SATB1 SATB homeobox 1 2.90397
PLPP6 phospholipid phosphatase 6 2.90013
H2BC12 H2B clustered histone 12 2.89385
FAT1 FAT atypical cadherin 1 2.89323
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.89226
UBQLN2 ubiquilin 2 2.86192
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.8589
EGR1 early growth response 1 2.85016
TAC4 tachykinin 4 (hemokinin) 2.80888
SFXN3 sideroflexin 3 2.75636
KIF5C kinesin family member 5C 2.7516
CYCS cytochrome c, somatic 2.71601
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.71354
DIPK1A divergent protein kinase domain 1A 2.68873
BAMBI BMP and activin membrane-bound inhibitor 2.66606
VGLL4 vestigial-like family member 4 2.65552
PLSCR4 phospholipid scramblase 4 2.63236
PDGFRB platelet-derived growth factor receptor, beta polypeptide 2.61458
ACP5 acid phosphatase 5, tartrate resistant 2.60455
PTK2 protein tyrosine kinase 2 2.59012
BBC3 BCL2 binding component 3 2.5867
PRKCD protein kinase C, delta 2.53678
INTS3 integrator complex subunit 3 2.53613
KDM5A lysine (K)-specific demethylase 5A 2.51451
LOC127933115 uncharacterized LOC127933115 2.50665
IFI6 interferon, alpha-inducible protein 6 2.50373
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.48612
ADGRE5 adhesion G protein-coupled receptor E5 2.48486
MTMR11 myotubularin related protein 11 2.47643
IGF1R insulin-like growth factor 1 receptor 2.46349
GARRE1 granule associated Rac and RHOG effector 1 2.45282
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.4403
MAPT microtubule-associated protein tau 2.43378
ACVR1 activin A receptor, type I 2.42857
OBP2B odorant binding protein 2B 2.42769
USP6NL USP6 N-terminal like 2.41078
MTMR6 myotubularin related protein 6 2.37309
TRIB1 tribbles pseudokinase 1 2.37246
RSU1 Ras suppressor protein 1 2.36821
BAX BCL2-associated X protein 2.36351
AKAP8 A kinase (PRKA) anchor protein 8 2.35473
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.34787
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.34306
AMDHD2 amidohydrolase domain containing 2 2.30156
TLE6 transducin-like enhancer of split 6 2.29908
PECR peroxisomal trans-2-enoyl-CoA reductase 2.28835
CNPY4 canopy FGF signaling regulator 4 2.27723
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.25054
RNF13 ring finger protein 13 2.24616
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.24111
TM9SF2 transmembrane 9 superfamily member 2 2.23832
PLSCR1 phospholipid scramblase 1 2.22304
VEGFC vascular endothelial growth factor C 2.20755
GPR162 G protein-coupled receptor 162 2.2068
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.19365
EPN2 epsin 2 2.16766
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.15551
CTSB cathepsin B 2.14431
SETD3 SET domain containing 3 2.13713
CCNA1 cyclin A1 2.12807
CYTH1 cytohesin 1 2.12349
H2AC6 H2A clustered histone 6 2.11258
IFI35 interferon-induced protein 35 2.10815
ADAM10 ADAM metallopeptidase domain 10 2.10596
NME7 NME/NM23 family member 7 2.09952
KIFC3 kinesin family member C3 2.09892
DHPS deoxyhypusine synthase 2.08249
ZBTB22 zinc finger and BTB domain containing 22 2.08088
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.08051
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.07977
RNF167 ring finger protein 167 2.05315
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.04614
COL1A1 collagen, type I, alpha 1 2.04573
TMCO1 transmembrane and coiled-coil domains 1 2.03889
DOK4 docking protein 4 2.03206
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 2.02468
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 2.02333
RUVBL1 RuvB-like AAA ATPase 1 2.01897
IGFALS insulin-like growth factor binding protein, acid labile subunit 2.01617
DACH1 dachshund family transcription factor 1 2.01378
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.01327
GLRX glutaredoxin (thioltransferase) 2.0022

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -9.94647
ADI1 acireductone dioxygenase 1 -9.26435
FAIM Fas apoptotic inhibitory molecule -6.78146
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -6.776
LDHD lactate dehydrogenase D -6.4664
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.42098
TCTN1 tectonic family member 1 -6.14367
GLOD4 glyoxalase domain containing 4 -5.90738
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -5.85697
ISOC1 isochorismatase domain containing 1 -5.77073
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.56133
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.49451
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -5.4793
ATF5 activating transcription factor 5 -5.47072
TCERG1 transcription elongation regulator 1 -5.35614
SCCPDH saccharopine dehydrogenase (putative) -5.29593
DNM1L dynamin 1-like -5.1908
GNAS GNAS complex locus -5.14765
STAP2 signal transducing adaptor family member 2 -5.105
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -4.92593
RPIA ribose 5-phosphate isomerase A -4.8944
KEAP1 kelch-like ECH-associated protein 1 -4.81028
GTPBP8 GTP-binding protein 8 (putative) -4.65556
CRELD2 cysteine-rich with EGF-like domains 2 -4.63947
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -4.59985
LRRC41 leucine rich repeat containing 41 -4.54414
PGM1 phosphoglucomutase 1 -4.52437
TMEM109 transmembrane protein 109 -4.49655
NUP85 nucleoporin 85kDa -4.45903
TLCD3A TLC domain containing 3A -4.44347
CDK1 cyclin-dependent kinase 1 -4.36966
SPAG7 sperm associated antigen 7 -4.36199
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.35007
STAMBP STAM binding protein -4.17739
CSK c-src tyrosine kinase -4.09649
ACAA1 acetyl-CoA acyltransferase 1 -4.08023
CCNA2 cyclin A2 -4.0791
OXA1L oxidase (cytochrome c) assembly 1-like -4.0185
CDC20 cell division cycle 20 -4.0055
MELK maternal embryonic leucine zipper kinase -3.87734
CDC25B cell division cycle 25B -3.84154
TATDN2 TatD DNase domain containing 2 -3.80965
SOAT2 sterol O-acyltransferase 2 -3.78369
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -3.77016
RRAGA Ras-related GTP binding A -3.70167
DCK deoxycytidine kinase -3.67887
CHEK1 checkpoint kinase 1 -3.64181
HADH hydroxyacyl-CoA dehydrogenase -3.62069
GALE UDP-galactose-4-epimerase -3.61374
GADD45A growth arrest and DNA-damage-inducible, alpha -3.50198
MSRA methionine sulfoxide reductase A -3.48609
AURKA aurora kinase A -3.46728
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.32162
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.31201
PLK1 polo-like kinase 1 -3.20965
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -3.1559
DEPDC1 DEP domain containing 1 -3.14394
THOC1 THO complex 1 -3.1273
PCNA proliferating cell nuclear antigen -3.1228
LOC124907782 dual specificity protein phosphatase 22 -3.12179
CDK4 cyclin-dependent kinase 4 -3.07227
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.07024
CDC25A cell division cycle 25A -2.97868
NRIP1 nuclear receptor interacting protein 1 -2.93125
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -2.90829
PROS1 protein S (alpha) -2.81102
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.8061
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.79742
SPAG4 sperm associated antigen 4 -2.7726
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.7665
ECH1 enoyl CoA hydratase 1, peroxisomal -2.75866
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.74646
NNT nicotinamide nucleotide transhydrogenase -2.73019
CPNE3 copine III -2.7255
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.71711
KRT13 keratin 13, type I -2.708
CASC3 cancer susceptibility candidate 3 -2.70021
ICAM3 intercellular adhesion molecule 3 -2.66138
ZBTB35 zinc finger and BTB domain containing 35 -2.63829
SLC35B1 solute carrier family 35, member B1 -2.63485
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.63117
TNIP2 TNFAIP3 interacting protein 2 -2.63084
TERT telomerase reverse transcriptase -2.58563
ACOT2 acyl-CoA thioesterase 2 -2.57854
TOMM34 translocase of outer mitochondrial membrane 34 -2.55714
CDT1 chromatin licensing and DNA replication factor 1 -2.55543
FBXO7 F-box protein 7 -2.54891
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.52889
ZW10 zw10 kinetochore protein -2.52422
PPCS phosphopantothenoylcysteine synthetase -2.51123
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.49921
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.49265
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.45647
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.45119
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.43615
FOXM1 forkhead box M1 -2.41969
ZNF232 zinc finger protein 232 -2.41418
BIRC5 baculoviral IAP repeat containing 5 -2.40949
NUP88 nucleoporin 88kDa -2.39859
MRPL18 mitochondrial ribosomal protein L18 -2.38911
IGHMBP2 immunoglobulin mu binding protein 2 -2.38379
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.35713
EGF epidermal growth factor -2.33832
MRPL39 mitochondrial ribosomal protein L39 -2.33396
TTC19 tetratricopeptide repeat domain 19 -2.30679
E2F1 E2F transcription factor 1 -2.30481
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.3044
FANCC Fanconi anemia, complementation group C -2.30425
DCTD dCMP deaminase -2.2983
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 -2.29194
LMF2 lipase maturation factor 2 -2.28679
MIS18A MIS18 kinetochore protein A -2.27518
TYK2 tyrosine kinase 2 -2.27371
CENPA centromere protein A -2.26676
GYS1 glycogen synthase 1 (muscle) -2.2666
PUF60 poly-U binding splicing factor 60KDa -2.26028
PAXBP1 PAX3 and PAX7 binding protein 1 -2.24877
EXO1 exonuclease 1 -2.24515
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 -2.23206
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.23116
MTARC1 mitochondrial amidoxime reducing component 1 -2.22978
AFM afamin -2.22662
SLC35E2B solute carrier family 35, member E2B -2.22301
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.2071
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.20282
CLK4 CDC-like kinase 4 -2.20122
MCM5 minichromosome maintenance complex component 5 -2.18581
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.18338
BCL7B B-cell CLL/lymphoma 7B -2.17853
CPT1B carnitine palmitoyltransferase 1B (muscle) -2.17848
PCCB propionyl CoA carboxylase, beta polypeptide -2.17146
VRK2 vaccinia related kinase 2 -2.17052
ZNF721 zinc finger protein 721 -2.16626
GTSE1 G-2 and S-phase expressed 1 -2.15721
SPRR1A small proline-rich protein 1A -2.13923
SERTAD2 SERTA domain containing 2 -2.13919
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.13653
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 -2.1344
CDK7 cyclin-dependent kinase 7 -2.12949
SRSF4 serine/arginine-rich splicing factor 4 -2.12643
RAD54L RAD54-like (S. cerevisiae) -2.11713
TOR1A torsin family 1, member A (torsin A) -2.11306
PEX13 peroxisomal biogenesis factor 13 -2.11117
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.10486
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.09341
LYRM1 LYR motif containing 1 -2.08895
CRYZ crystallin, zeta (quinone reductase) -2.08858
DONSON downstream neighbor of SON -2.08659
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.08285
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.08132
KLHL21 kelch-like family member 21 -2.08061
PHF10 PHD finger protein 10 -2.07933
ZFY zinc finger protein, Y-linked -2.07409
EAPP E2F-associated phosphoprotein -2.06175
TMEM97 transmembrane protein 97 -2.06091
NRTN neurturin -2.06059
PARP1 poly (ADP-ribose) polymerase 1 -2.05269
SNX11 sorting nexin 11 -2.05131
RYR3 ryanodine receptor 3 -2.04845
MORC4 MORC family CW-type zinc finger 4 -2.04107
ECEL1 endothelin converting enzyme-like 1 -2.03947
HMGN2 high mobility group nucleosomal binding domain 2 -2.03641
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.03353
NVL nuclear VCP-like -2.03296
LGALS7B lectin, galactoside-binding, soluble, 7B -2.03198
DERA deoxyribose-phosphate aldolase (putative) -2.02409
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.02014
WASF2 WAS protein family, member 2 -2.00276
HRAS Harvey rat sarcoma viral oncogene homolog -2.00128