CRCGN009_HEPG2_24H:K14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description alpha-methyldopa sesquihydrate 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN009_HEPG2_24H:K14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.37238
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.95402
CARMIL1 capping protein regulator and myosin 1 linker 1 4.82359
TRIM13 tripartite motif containing 13 4.26249
ABHD6 abhydrolase domain containing 6 4.17235
HLA-DMA major histocompatibility complex, class II, DM alpha 4.17093
LOC122526780 uncharacterized LOC122526780 4.00535
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.98147
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.9381
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.71272
PPARG peroxisome proliferator-activated receptor gamma 3.71116
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.67448
MEST mesoderm specific transcript 3.66347
ZNF589 zinc finger protein 589 3.62176
GARRE1 granule associated Rac and RHOG effector 1 3.44415
GSTZ1 glutathione S-transferase zeta 1 3.28085
MAP7 microtubule-associated protein 7 3.00718
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.97919
CORO1A coronin, actin binding protein, 1A 2.92592
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.87103
TBC1D31 TBC1 domain family, member 31 2.51598
PMM2 phosphomannomutase 2 2.44874
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.33942
SATB1 SATB homeobox 1 2.31677
DRC9 dynein regulatory complex subunit 9 2.30729
TCTA T-cell leukemia translocation altered 2.23748
SUMF2 sulfatase modifying factor 2 2.20564
PON2 paraoxonase 2 2.18277
VGLL4 vestigial-like family member 4 2.17512
CCNA1 cyclin A1 2.13498
RACGAP1 Rac GTPase activating protein 1 2.11991
TXNL4B thioredoxin-like 4B 2.11907
CDK3 cyclin-dependent kinase 3 2.11391
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 2.09393
TESK1 testis-specific kinase 1 2.04191

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -6.70399
LDHD lactate dehydrogenase D -4.86396
UGDH UDP-glucose 6-dehydrogenase -4.31396
MAPK13 mitogen-activated protein kinase 13 -4.06843
OXA1L oxidase (cytochrome c) assembly 1-like -3.95933
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.39644
ZW10 zw10 kinetochore protein -3.34575
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.28016
WASHC4 WASH complex subunit 4 -3.18424
RAI14 retinoic acid induced 14 -2.96409
TXNRD1 thioredoxin reductase 1 -2.93096
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.77248
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.70031
PRSS58 protease, serine, 58 -2.48885
HEATR1 HEAT repeat containing 1 -2.46031
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.43108
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.40297
HCFC2 host cell factor C2 -2.27739
SYTL2 synaptotagmin-like 2 -2.13172
PLAT plasminogen activator, tissue -2.10818
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.10517
TCEAL4 transcription elongation factor A (SII)-like 4 -2.08006
PGAP6 post-GPI attachment to proteins 6 -2.01942