CRCGN009_HEPG2_24H:K15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description alpha-methyldopa sesquihydrate 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN009_HEPG2_24H:K15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 8.73029
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.28501
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.10282
ANO1 anoctamin 1, calcium activated chloride channel 5.0
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.67802
E2F2 E2F transcription factor 2 4.64842
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.62128
SFTPB surfactant protein B 4.05345
NUP133 nucleoporin 133kDa 3.86248
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.79402
NOTCH1 notch 1 3.56924
PFKL phosphofructokinase, liver 3.33255
DHDDS dehydrodolichyl diphosphate synthase 3.30724
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.2449
TRIM13 tripartite motif containing 13 3.16969
LPAR2 lysophosphatidic acid receptor 2 3.03989
SKIC8 SKI8 subunit of superkiller complex 2.93202
CCL2 chemokine (C-C motif) ligand 2 2.71715
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.69426
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.56175
PRPF31 pre-mRNA processing factor 31 2.53038
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.44447
DIPK1A divergent protein kinase domain 1A 2.37277
RPA3 replication protein A3, 14kDa 2.31721
FBXL8 F-box and leucine-rich repeat protein 8 2.31451
GATD3 glutamine amidotransferase class 1 domain containing 3 2.22905
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.16825
GYS1 glycogen synthase 1 (muscle) 2.15545
COPS7A COP9 signalosome subunit 7A 2.13427
RUVBL2 RuvB-like AAA ATPase 2 2.12272
DUSP4 dual specificity phosphatase 4 2.11776
PTOV1 prostate tumor overexpressed 1 2.06466
EPHB2 EPH receptor B2 2.00846

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.80545
TRIB3 tribbles pseudokinase 3 -5.28434
ADI1 acireductone dioxygenase 1 -5.16014
CSK c-src tyrosine kinase -5.04912
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.94364
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.74166
PCNA proliferating cell nuclear antigen -4.53858
DSG2 desmoglein 2 -4.49362
ZMIZ1 zinc finger, MIZ-type containing 1 -4.30053
OXA1L oxidase (cytochrome c) assembly 1-like -3.36841
ITGB1BP1 integrin beta 1 binding protein 1 -2.83605
TOMM70 translocase of outer mitochondrial membrane 70 -2.61243
CCNB2 cyclin B2 -2.52099
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.51851
TOR1A torsin family 1, member A (torsin A) -2.47686
WASHC4 WASH complex subunit 4 -2.38048
FBXL12 F-box and leucine-rich repeat protein 12 -2.27354
ADGRG6 adhesion G protein-coupled receptor G6 -2.13446
PLA2G15 phospholipase A2, group XV -2.03948