CRCGN009_HEPG2_24H:K16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description alpha-methyldopa sesquihydrate 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN009_HEPG2_24H:K16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 7.33555
MAP7 microtubule-associated protein 7 6.01279
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.04526
SOCS2 suppressor of cytokine signaling 2 4.38135
VAV3 vav 3 guanine nucleotide exchange factor 4.14956
GATA3 GATA binding protein 3 4.05502
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.98952
STIMATE STIM activating enhancer 3.8927
DYNLT3 dynein, light chain, Tctex-type 3 3.76802
CHMP6 charged multivesicular body protein 6 3.71973
MYLK myosin light chain kinase 3.59347
NOTCH1 notch 1 3.43609
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.42216
GPER1 G protein-coupled estrogen receptor 1 3.32957
TIAM1 T-cell lymphoma invasion and metastasis 1 3.30947
SNAP25 synaptosomal-associated protein, 25kDa 3.30379
BACE2 beta-site APP-cleaving enzyme 2 3.1555
CCDC85B coiled-coil domain containing 85B 3.04575
MICALL1 MICAL-like 1 2.6382
CYCS cytochrome c, somatic 2.59161
PMM2 phosphomannomutase 2 2.52205
KIFBP kinesin family binding protein 2.4599
NANOS3 nanos homolog 3 (Drosophila) 2.41966
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.39788
MEST mesoderm specific transcript 2.30521
BTK Bruton agammaglobulinemia tyrosine kinase 2.29306
GPATCH8 G patch domain containing 8 2.22928
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.22768
PRAF2 PRA1 domain family, member 2 2.2268
TGFB3 transforming growth factor, beta 3 2.22146
CEMIP2 cell migration inducing hyaluronidase 2 2.19503
NOSIP nitric oxide synthase interacting protein 2.16188
CDK19 cyclin-dependent kinase 19 2.16138
CRY1 cryptochrome circadian clock 1 2.05182
FCHO1 FCH domain only 1 2.02336
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.00277

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -6.53765
CCNB2 cyclin B2 -5.22609
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.22314
FGFR4 fibroblast growth factor receptor 4 -4.8184
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.79312
PCNA proliferating cell nuclear antigen -4.66275
NGRN neugrin, neurite outgrowth associated -4.43714
CSK c-src tyrosine kinase -4.19253
OXA1L oxidase (cytochrome c) assembly 1-like -4.05211
CDC20 cell division cycle 20 -3.68633
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.50341
LOC124907782 dual specificity protein phosphatase 22 -3.35457
ANKRD10 ankyrin repeat domain 10 -3.23247
EIF5 eukaryotic translation initiation factor 5 -3.18035
CCDC92 coiled-coil domain containing 92 -2.39545
SPAG4 sperm associated antigen 4 -2.3898
SLC35F2 solute carrier family 35, member F2 -2.22277
CHIC2 cysteine-rich hydrophobic domain 2 -2.20843
TRAPPC6A trafficking protein particle complex 6A -2.19741
CDK14 cyclin-dependent kinase 14 -2.15734
ETHE1 ethylmalonic encephalopathy 1 -2.07645
HYOU1 hypoxia up-regulated 1 -2.04688
RGS2 regulator of G-protein signaling 2 -2.00362