| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | alpha-methyldopa sesquihydrate 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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54 genes differentially expressed following the CRCGN009_HEPG2_24H:K18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LCN2 | lipocalin 2 | 7.09374 |
| CCL2 | chemokine (C-C motif) ligand 2 | 5.62309 |
| RPL39L | ribosomal protein L39-like | 4.93585 |
| TAC4 | tachykinin 4 (hemokinin) | 4.26788 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 4.03622 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 4.02479 |
| LPAR2 | lysophosphatidic acid receptor 2 | 3.97141 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.91806 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 3.72165 |
| CBR3 | carbonyl reductase 3 | 3.71743 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.61795 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.57121 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.1337 |
| KDM5A | lysine (K)-specific demethylase 5A | 2.97193 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.89626 |
| MAP7 | microtubule-associated protein 7 | 2.84731 |
| PFKL | phosphofructokinase, liver | 2.7232 |
| NUCB2 | nucleobindin 2 | 2.57612 |
| PLSCR1 | phospholipid scramblase 1 | 2.54648 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 2.53168 |
| ACP6 | acid phosphatase 6, lysophosphatidic | 2.41165 |
| EPN2 | epsin 2 | 2.33168 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 2.26331 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.24714 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 2.2314 |
| JADE2 | jade family PHD finger 2 | 2.21016 |
| ANO10 | anoctamin 10 | 2.1891 |
| BLMH | bleomycin hydrolase | 2.0963 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.09339 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 2.02469 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.00105 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -7.68107 |
| PCNA | proliferating cell nuclear antigen | -5.72117 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.4458 |
| MRPS2 | mitochondrial ribosomal protein S2 | -4.25248 |
| CDC20 | cell division cycle 20 | -3.76992 |
| PLK1 | polo-like kinase 1 | -3.62274 |
| HMG20B | high mobility group 20B | -3.54313 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -3.4988 |
| LDHD | lactate dehydrogenase D | -3.48738 |
| STX4 | syntaxin 4 | -3.32231 |
| CCNB2 | cyclin B2 | -3.2368 |
| VDAC1 | voltage-dependent anion channel 1 | -3.15904 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.73352 |
| PEG10 | paternally expressed 10 | -2.72459 |
| CCNB1 | cyclin B1 | -2.5177 |
| NVL | nuclear VCP-like | -2.47798 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.36268 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.27686 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.1991 |
| PRPF4 | pre-mRNA processing factor 4 | -2.09047 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.03588 |
| ZNF580 | zinc finger protein 580 | -2.02626 |
| KIF2C | kinesin family member 2C | -2.00273 |
