CRCGN009_HEPG2_24H:K20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2-chloroethyl)trimethylammonium chloride 20.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN009_HEPG2_24H:K20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.53429
ABHD6 abhydrolase domain containing 6 5.76574
LCN2 lipocalin 2 5.43831
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.11492
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.73972
CXCL2 chemokine (C-X-C motif) ligand 2 4.63629
E2F2 E2F transcription factor 2 4.47455
INTS3 integrator complex subunit 3 4.41679
HLA-DMA major histocompatibility complex, class II, DM alpha 4.29025
ATP11B ATPase, class VI, type 11B 3.9322
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.89824
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.82423
HOXA10 homeobox A10 3.73189
CCNF cyclin F 3.70669
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.69077
STIMATE STIM activating enhancer 3.64305
HDGFL3 HDGF like 3 3.41494
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.38638
PFKL phosphofructokinase, liver 3.09825
RRAGA Ras-related GTP binding A 2.88687
UBE2A ubiquitin-conjugating enzyme E2A 2.85606
HLA-DRA major histocompatibility complex, class II, DR alpha 2.82858
MAP7 microtubule-associated protein 7 2.7458
EVL Enah/Vasp-like 2.50839
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.39671
GARRE1 granule associated Rac and RHOG effector 1 2.29467
MDM4 MDM4, p53 regulator 2.28863
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.28348
DENND2D DENN/MADD domain containing 2D 2.26903
PDCD5 programmed cell death 5 2.24139
NRN1 neuritin 1 2.1563
SMIM40 small integral membrane protein 40 2.1543
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.14139
FZD6 frizzled class receptor 6 2.06948
NPR1 natriuretic peptide receptor 1 2.06845
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.0643
LAMA5 laminin, alpha 5 2.05971
MTHFSD methenyltetrahydrofolate synthetase domain containing 2.057
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.04537
FZD10 frizzled class receptor 10 2.01008

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -8.4506
LAP3 leucine aminopeptidase 3 -4.79296
NUP85 nucleoporin 85kDa -4.54892
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.49631
TLR4 toll-like receptor 4 -4.37806
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.12473
VAT1 vesicle amine transport 1 -4.10949
PEG10 paternally expressed 10 -3.82105
CD58 CD58 molecule -3.80024
NCK1 NCK adaptor protein 1 -3.5101
WASHC4 WASH complex subunit 4 -3.34247
PCNA proliferating cell nuclear antigen -3.32342
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.17387
MAPK13 mitogen-activated protein kinase 13 -3.13639
JPT1 Jupiter microtubule associated homolog 1 -2.60338
MTFR1 mitochondrial fission regulator 1 -2.58862
KCTD2 potassium channel tetramerization domain containing 2 -2.52139
MRPL58 mitochondrial ribosomal protein L58 -2.33489
AARSD1 alanyl-tRNA synthetase domain containing 1 -2.30287
NRIP1 nuclear receptor interacting protein 1 -2.25513
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.22428
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.21807
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.21124
MYBPC1 myosin binding protein C, slow type -2.18365
TMEM94 transmembrane protein 94 -2.15961
PECR peroxisomal trans-2-enoyl-CoA reductase -2.13223
MRPS7 mitochondrial ribosomal protein S7 -2.04305
WBP2 WW domain binding protein 2 -2.02165