CRCGN009_HEPG2_24H:K24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2-chloroethyl)trimethylammonium chloride 1.27 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN009_HEPG2_24H:K24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 4.36758
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.30977
UBQLN2 ubiquilin 2 4.27979
C2CD2 C2 calcium-dependent domain containing 2 3.94756
MYLK myosin light chain kinase 3.44944
ADRB2 adrenoceptor beta 2, surface 3.44869
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.44164
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.33463
PPARG peroxisome proliferator-activated receptor gamma 3.13484
CRTAP cartilage associated protein 2.9421
CBR1 carbonyl reductase 1 2.79612
LCN2 lipocalin 2 2.77447
LPAR2 lysophosphatidic acid receptor 2 2.76167
PMM2 phosphomannomutase 2 2.63481
MAP7 microtubule-associated protein 7 2.42473
TIAM1 T-cell lymphoma invasion and metastasis 1 2.30221
CYCS cytochrome c, somatic 2.15742
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.14771
CEMIP2 cell migration inducing hyaluronidase 2 2.12674
ADAM10 ADAM metallopeptidase domain 10 2.0906

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.84797
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.72179
LDHD lactate dehydrogenase D -6.62767
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.01235
OXA1L oxidase (cytochrome c) assembly 1-like -4.34664
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.99688
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.91791
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.68925
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.45698
FGFR4 fibroblast growth factor receptor 4 -3.1377
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.99234
PCNA proliferating cell nuclear antigen -2.91049
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.49391
UBE3C ubiquitin protein ligase E3C -2.47274
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.45607
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.44955
NGB neuroglobin -2.35986
LOC124907782 dual specificity protein phosphatase 22 -2.34198
CENPO centromere protein O -2.2924
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 -2.23372
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific -2.19001
HEATR1 HEAT repeat containing 1 -2.16225
SSTR5 somatostatin receptor 5 -2.16073
NRIP1 nuclear receptor interacting protein 1 -2.14164
ZFR2 zinc finger RNA binding protein 2 -2.14042
OSBPL11 oxysterol binding protein-like 11 -2.13034
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -2.12725
DAGLA diacylglycerol lipase, alpha -2.11632
CAPN15 calpain 15 -2.10444
SCCPDH saccharopine dehydrogenase (putative) -2.10093
PRDM12 PR domain containing 12 -2.10011
PKD1 polycystic kidney disease 1 (autosomal dominant) -2.07453
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K -2.07451
POU3F4 POU class 3 homeobox 4 -2.06061
HUNK hormonally up-regulated Neu-associated kinase -2.05901
SORBS1 sorbin and SH3 domain containing 1 -2.05734
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 -2.05534
ASMT acetylserotonin O-methyltransferase -2.04088
WRNIP1 Werner helicase interacting protein 1 -2.02335
STEAP1B STEAP family member 1B -2.01969