CRCGN009_HEPG2_24H:L04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aspirin 4.97 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN009_HEPG2_24H:L04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 7.62163
GPATCH8 G patch domain containing 8 5.63192
CHMP6 charged multivesicular body protein 6 4.8533
GPER1 G protein-coupled estrogen receptor 1 4.67592
JADE2 jade family PHD finger 2 3.69206
MAP7 microtubule-associated protein 7 3.17587
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.06419
SQOR sulfide quinone oxidoreductase 2.99997
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.95006
BAD BCL2-associated agonist of cell death 2.82215
STIMATE STIM activating enhancer 2.80654
ANO10 anoctamin 10 2.66768
LPAR2 lysophosphatidic acid receptor 2 2.64828
WDR7 WD repeat domain 7 2.50038
GATA2 GATA binding protein 2 2.39601
RRAGA Ras-related GTP binding A 2.37134
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.34342
GSTZ1 glutathione S-transferase zeta 1 2.32025
CARMIL1 capping protein regulator and myosin 1 linker 1 2.24795
KIF20A kinesin family member 20A 2.17834
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.16172
MICALL1 MICAL-like 1 2.1602
SOCS2 suppressor of cytokine signaling 2 2.13353
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.07534
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.03402

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -7.63344
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.59484
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.42067
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.44439
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.11075
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.9125
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.77951
UGDH UDP-glucose 6-dehydrogenase -3.03941
PRPF4 pre-mRNA processing factor 4 -2.51084
RGS2 regulator of G-protein signaling 2 -2.47583
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.47072
ZNF134 zinc finger protein 134 -2.17646
TEX30 testis expressed 30 -2.14117
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.13953
PDS5A PDS5 cohesin associated factor A -2.09751
FGFR4 fibroblast growth factor receptor 4 -2.05308
ZNF257 zinc finger protein 257 -2.0304
ZNF551 zinc finger protein 551 -2.01792
NR0B1 nuclear receptor subfamily 0, group B, member 1 -2.01767