CRCGN009_HEPG2_24H:L10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-thiobis(6-tert-butyl-m-cresol) 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

108 genes differentially expressed following the CRCGN009_HEPG2_24H:L10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPL39L ribosomal protein L39-like 6.89839
CNPY3 canopy FGF signaling regulator 3 6.10868
TIAM1 T-cell lymphoma invasion and metastasis 1 6.00234
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.73938
DIPK1A divergent protein kinase domain 1A 4.39713
TRIB3 tribbles pseudokinase 3 3.94773
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.94035
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.83628
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.81857
BACE2 beta-site APP-cleaving enzyme 2 3.6767
LPAR2 lysophosphatidic acid receptor 2 3.63775
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.53791
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.53282
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.50338
DDIT4 DNA-damage-inducible transcript 4 3.42065
E2F2 E2F transcription factor 2 3.37931
CBR3 carbonyl reductase 3 3.0305
INPP1 inositol polyphosphate-1-phosphatase 2.92289
CEMIP2 cell migration inducing hyaluronidase 2 2.83031
FAT1 FAT atypical cadherin 1 2.81063
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.63633
VAT1 vesicle amine transport 1 2.61921
PHGDH phosphoglycerate dehydrogenase 2.54119
NPDC1 neural proliferation, differentiation and control, 1 2.49432
CCP110 centriolar coiled coil protein 110kDa 2.46281
CARMIL1 capping protein regulator and myosin 1 linker 1 2.45873
DSG2 desmoglein 2 2.41743
FAIM Fas apoptotic inhibitory molecule 2.40659
ABHD6 abhydrolase domain containing 6 2.38056
PEX11A peroxisomal biogenesis factor 11 alpha 2.36074
RRAGA Ras-related GTP binding A 2.34463
DDTL D-dopachrome tautomerase-like 2.23518
AARS1 alanyl-tRNA synthetase 1 2.22154
MTERF3 mitochondrial transcription termination factor 3 2.20857
GATA3 GATA binding protein 3 2.18802
ATF4 activating transcription factor 4 2.18719
KLHL9 kelch-like family member 9 2.13748
EPHB6 EPH receptor B6 2.11276
DHPS deoxyhypusine synthase 2.11061
LY96 lymphocyte antigen 96 2.1071
TPD52L2 tumor protein D52-like 2 2.09692
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.07535
STIMATE STIM activating enhancer 2.07015
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.0602
INF2 inverted formin, FH2 and WH2 domain containing 2.05754
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.05065
KDM5A lysine (K)-specific demethylase 5A 2.04252
PFKL phosphofructokinase, liver 2.02357

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.68894
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.04254
TCTN1 tectonic family member 1 -5.857
PLK1 polo-like kinase 1 -5.00799
FASTKD5 FAST kinase domains 5 -4.96828
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.85878
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.75349
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.67033
C2CD5 C2 calcium-dependent domain containing 5 -3.52884
EGF epidermal growth factor -3.48656
ZNF274 zinc finger protein 274 -3.4511
LDHD lactate dehydrogenase D -3.43961
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.34369
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -3.33515
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.33205
DNM1L dynamin 1-like -3.25836
PCNA proliferating cell nuclear antigen -3.21905
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.07262
FHL2 four and a half LIM domains 2 -2.94427
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.94043
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.92011
CCNB2 cyclin B2 -2.89671
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.85673
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.83771
CAPNS1 calpain, small subunit 1 -2.67999
CYTL1 cytokine-like 1 -2.62013
MELK maternal embryonic leucine zipper kinase -2.59797
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.49212
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.45192
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.35622
MEOX2 mesenchyme homeobox 2 -2.33104
CETN2 centrin, EF-hand protein, 2 -2.31509
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.29868
ALDOC aldolase C, fructose-bisphosphate -2.28972
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.28947
PGAM2 phosphoglycerate mutase 2 (muscle) -2.28593
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.27825
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -2.24558
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.23231
NME5 NME/NM23 family member 5 -2.22953
COX7B cytochrome c oxidase subunit VIIb -2.22216
SPHK2 sphingosine kinase 2 -2.20083
CRYBB1 crystallin, beta B1 -2.19696
CDK1 cyclin-dependent kinase 1 -2.1905
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.14927
VBP1 von Hippel-Lindau binding protein 1 -2.13634
PGAM4 phosphoglycerate mutase family member 4 -2.12891
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.09038
COXFA4 cytochrome c oxidase associated subunit FA4 -2.08242
KRT36 keratin 36, type I -2.05373
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.05355
NKX2-5 NK2 homeobox 5 -2.05336
PGCKA1 PDCD10 and GCKIII kinases associated 1 -2.04997
SCTR secretin receptor -2.04168
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.03805
MED21 mediator complex subunit 21 -2.01447
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.01196
ELSPBP1 epididymal sperm binding protein 1 -2.01015
LDHB lactate dehydrogenase B -2.00532
NUP62 nucleoporin 62kDa -2.00184