CRCGN009_HEPG2_24H:L12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-thiobis(6-tert-butyl-m-cresol) 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

334 genes differentially expressed following the CRCGN009_HEPG2_24H:L12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 7.78354
RPL39L ribosomal protein L39-like 7.65185
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.56478
BACE2 beta-site APP-cleaving enzyme 2 7.50545
ADRB2 adrenoceptor beta 2, surface 7.45781
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 7.05395
E2F2 E2F transcription factor 2 6.77119
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.658
CXCR4 chemokine (C-X-C motif) receptor 4 5.4327
MAP7 microtubule-associated protein 7 5.33756
NOTCH1 notch 1 5.22068
CARMIL1 capping protein regulator and myosin 1 linker 1 5.20175
TIAM1 T-cell lymphoma invasion and metastasis 1 5.09321
PPARG peroxisome proliferator-activated receptor gamma 5.0347
PNKP polynucleotide kinase 3'-phosphatase 4.8958
PLS1 plastin 1 4.80473
CCDC85B coiled-coil domain containing 85B 4.78845
CYCS cytochrome c, somatic 4.76339
CBR3 carbonyl reductase 3 4.55384
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.4522
PLSCR1 phospholipid scramblase 1 4.40618
NANOS3 nanos homolog 3 (Drosophila) 4.40207
RAB11FIP2 RAB11 family interacting protein 2 (class I) 4.1729
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.12214
VAV3 vav 3 guanine nucleotide exchange factor 4.09527
LOC122526780 uncharacterized LOC122526780 4.03903
HOXA10 homeobox A10 4.03127
LCN2 lipocalin 2 4.02683
UBQLN2 ubiquilin 2 3.92421
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.65051
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.59445
DYNLT3 dynein, light chain, Tctex-type 3 3.52673
PRRX2 paired related homeobox 2 3.3482
GSTM2 glutathione S-transferase mu 2 (muscle) 3.34078
CNPY3 canopy FGF signaling regulator 3 3.31419
TAC4 tachykinin 4 (hemokinin) 3.20297
STAP2 signal transducing adaptor family member 2 3.20148
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.16027
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 3.11676
HEBP1 heme binding protein 1 3.02548
PRKCH protein kinase C, eta 2.97955
STEAP1 six transmembrane epithelial antigen of the prostate 1 2.94948
LOXL1 lysyl oxidase-like 1 2.94073
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.93076
RCN3 reticulocalbin 3, EF-hand calcium binding domain 2.92243
GARRE1 granule associated Rac and RHOG effector 1 2.90149
TBPL1 TBP-like 1 2.80807
CDPF1 cysteine-rich, DPF motif domain containing 1 2.75674
TFF1 trefoil factor 1 2.75506
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 2.75051
CIAO3 cytosolic iron-sulfur assembly component 3 2.70084
GPX2 glutathione peroxidase 2 2.6937
KIF5C kinesin family member 5C 2.69005
JADE2 jade family PHD finger 2 2.68075
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.65219
ZBTB39 zinc finger and BTB domain containing 39 2.63886
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.61887
FCHO1 FCH domain only 1 2.61168
CD7 CD7 molecule 2.60057
TRPM4 transient receptor potential cation channel, subfamily M, member 4 2.59816
STK10 serine/threonine kinase 10 2.59591
SBDS Shwachman-Bodian-Diamond syndrome 2.57021
OPLAH 5-oxoprolinase (ATP-hydrolysing) 2.56754
FBXO7 F-box protein 7 2.56751
IGFBP4 insulin-like growth factor binding protein 4 2.56608
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.56367
RASIP1 Ras interacting protein 1 2.55123
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.53147
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.50182
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.5018
GATA3 GATA binding protein 3 2.49229
HR hair growth associated 2.48959
MMP1 matrix metallopeptidase 1 2.48487
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.47899
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.47631
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.47402
CHN1 chimerin 1 2.45771
SNAP25 synaptosomal-associated protein, 25kDa 2.45186
CD248 CD248 molecule, endosialin 2.42304
HOXC5 homeobox C5 2.41889
MCM3 minichromosome maintenance complex component 3 2.39555
MAPK4 mitogen-activated protein kinase 4 2.3951
CNTFR ciliary neurotrophic factor receptor 2.38709
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.38485
THBS4 thrombospondin 4 2.38477
INSL4 insulin-like 4 (placenta) 2.38346
SIPA1 signal-induced proliferation-associated 1 2.38274
NINL ninein-like 2.37276
ARHGAP4 Rho GTPase activating protein 4 2.37246
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.36964
PIH1D1 PIH1 domain containing 1 2.36729
ATAD3A ATPase family, AAA domain containing 3A 2.3609
CD5 CD5 molecule 2.35811
KDM3B lysine (K)-specific demethylase 3B 2.34315
CIB2 calcium and integrin binding family member 2 2.32421
MYBPC3 myosin binding protein C, cardiac 2.3228
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.32209
PCDHB11 protocadherin beta 11 2.3135
TGIF1 TGFB-induced factor homeobox 1 2.31166
SH2D1A SH2 domain containing 1A 2.31134
MSMB microseminoprotein, beta- 2.30098
R3HDM2 R3H domain containing 2 2.28553
AEBP1 AE binding protein 1 2.28534
RARG retinoic acid receptor, gamma 2.27857
NUP133 nucleoporin 133kDa 2.27827
GJA3 gap junction protein, alpha 3, 46kDa 2.27198
MYOD1 myogenic differentiation 1 2.27108
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.26662
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.26493
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.26443
FBXL7 F-box and leucine-rich repeat protein 7 2.25149
PLCD1 phospholipase C, delta 1 2.24985
RYBP RING1 and YY1 binding protein 2.24703
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.24658
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.24333
ALDOC aldolase C, fructose-bisphosphate 2.23157
DCXR dicarbonyl/L-xylulose reductase 2.23107
SASH1 SAM and SH3 domain containing 1 2.22217
PARP1 poly (ADP-ribose) polymerase 1 2.22099
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.21924
MEN1 multiple endocrine neoplasia I 2.21664
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.20922
A4GALT alpha 1,4-galactosyltransferase 2.20385
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.20266
DUX4 double homeobox 4 2.19957
UNC93B1 unc-93 homolog B1 (C. elegans) 2.19921
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 2.19705
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.19292
CCL2 chemokine (C-C motif) ligand 2 2.18947
IRF2 interferon regulatory factor 2 2.18814
CD1B CD1b molecule 2.18632
KHNYN KH and NYN domain containing 2.18585
CFAP69 cilia and flagella associated protein 69 2.18524
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.18275
CLINT1 clathrin interactor 1 2.17938
PRSS22 protease, serine, 22 2.17246
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.16311
IL22 interleukin 22 2.15951
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.15802
MORN1 MORN repeat containing 1 2.15793
GPRC5C G protein-coupled receptor, class C, group 5, member C 2.14972
FOXO3 forkhead box O3 2.14724
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.13886
ETV4 ets variant 4 2.13801
ATP7B ATPase, Cu++ transporting, beta polypeptide 2.13525
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.13473
MARCKSL1 MARCKS-like 1 2.12855
CCNF cyclin F 2.122
FGF6 fibroblast growth factor 6 2.11605
ESRRA estrogen-related receptor alpha 2.10959
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.10141
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2.0986
TBKBP1 TBK1 binding protein 1 2.0965
TBC1D31 TBC1 domain family, member 31 2.09243
FAM53B family with sequence similarity 53, member B 2.09088
SLC25A46 solute carrier family 25, member 46 2.08923
INSIG1 insulin induced gene 1 2.08703
LMX1B LIM homeobox transcription factor 1, beta 2.08701
CTC1 CTS telomere maintenance complex component 1 2.07653
COQ3 coenzyme Q3 methyltransferase 2.07653
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.06927
LSR lipolysis stimulated lipoprotein receptor 2.0687
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2.06546
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.06542
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2.06493
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.06459
CT55 cancer/testis antigen 55 2.06452
DNASE1L2 deoxyribonuclease I-like 2 2.06242
PLCH2 phospholipase C, eta 2 2.05636
OVOL3 ovo-like zinc finger 3 2.05418
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 2.0517
CCDC92 coiled-coil domain containing 92 2.04662
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.04517
COMP cartilage oligomeric matrix protein 2.04047
CCDC28A coiled-coil domain containing 28A 2.03926
ERCC2 excision repair cross-complementation group 2 2.0388
EXOSC4 exosome component 4 2.03685
GPN2 GPN-loop GTPase 2 2.03418
PTCRA pre T-cell antigen receptor alpha 2.02589
IGFBP3 insulin-like growth factor binding protein 3 2.02521
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.0252
TGM5 transglutaminase 5 2.02481
PIBF1 progesterone immunomodulatory binding factor 1 2.0189
CMC2 C-x(9)-C motif containing 2 2.01696
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.01522
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.01306
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 2.01256
UNC13A unc-13 homolog A (C. elegans) 2.00818
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.00683
HCCS holocytochrome c synthase 2.00581

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -8.00282
TARBP1 TAR (HIV-1) RNA binding protein 1 -7.81281
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.61193
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -7.28474
PCNA proliferating cell nuclear antigen -7.12365
DNM1L dynamin 1-like -6.77362
ZDHHC6 zinc finger, DHHC-type containing 6 -6.75776
MAPK13 mitogen-activated protein kinase 13 -6.35341
ANKRD10 ankyrin repeat domain 10 -6.23102
TCTN1 tectonic family member 1 -6.06655
SLC35F2 solute carrier family 35, member F2 -5.36302
MRPS2 mitochondrial ribosomal protein S2 -5.32718
GNAS GNAS complex locus -5.10282
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.68698
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.55019
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.44276
NVL nuclear VCP-like -4.39525
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.2016
LDHD lactate dehydrogenase D -4.1367
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.11684
FASTKD5 FAST kinase domains 5 -4.01019
NRIP1 nuclear receptor interacting protein 1 -3.9532
TRIB3 tribbles pseudokinase 3 -3.91705
ISOC1 isochorismatase domain containing 1 -3.90454
CCNB2 cyclin B2 -3.69071
NGRN neugrin, neurite outgrowth associated -3.68274
REEP5 receptor accessory protein 5 -3.57713
ZMIZ1 zinc finger, MIZ-type containing 1 -3.43268
TBCB tubulin folding cofactor B -3.35652
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.20525
WDR7 WD repeat domain 7 -3.17662
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -3.17471
CCNB1 cyclin B1 -3.12617
LOC124907782 dual specificity protein phosphatase 22 -3.08099
HMG20B high mobility group 20B -3.06724
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.97436
UBE3C ubiquitin protein ligase E3C -2.97023
EXT1 exostosin glycosyltransferase 1 -2.9632
FBXL12 F-box and leucine-rich repeat protein 12 -2.96279
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.93292
MSL1 male-specific lethal 1 homolog (Drosophila) -2.9186
PUM3 pumilio RNA binding family member 3 -2.9099
CD320 CD320 molecule -2.89488
TM9SF3 transmembrane 9 superfamily member 3 -2.88537
MAP3K7CL MAP3K7 C-terminal like -2.88483
CRELD2 cysteine-rich with EGF-like domains 2 -2.86802
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.86404
TLCD3A TLC domain containing 3A -2.84957
RNF167 ring finger protein 167 -2.80738
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -2.79575
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.76741
NCSTN nicastrin -2.73983
TES testin LIM domain protein -2.67862
PGAP3 post-GPI attachment to proteins 3 -2.66066
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.62959
PDIA3 protein disulfide isomerase family A, member 3 -2.58642
UNG uracil-DNA glycosylase -2.58596
MACF1 microtubule-actin crosslinking factor 1 -2.583
ZNF146 zinc finger protein 146 -2.57825
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.55573
DSN1 DSN1, MIS12 kinetochore complex component -2.54298
ZNF573 zinc finger protein 573 -2.52728
CDC25B cell division cycle 25B -2.49448
ITGB1BP1 integrin beta 1 binding protein 1 -2.47695
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.46571
FAM216A family with sequence similarity 216, member A -2.43528
ZNF586 zinc finger protein 586 -2.42458
HEATR1 HEAT repeat containing 1 -2.424
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -2.39881
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.3826
HTN1 histatin 1 -2.37427
ZNF281 zinc finger protein 281 -2.36923
CTSA cathepsin A -2.36736
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 -2.36379
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.36037
GLIPR1 GLI pathogenesis-related 1 -2.33984
PEG10 paternally expressed 10 -2.33863
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -2.31603
MAB21L4 mab-21 like 4 -2.31319
CDK6 cyclin-dependent kinase 6 -2.29244
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.28186
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.2769
CST5 cystatin D -2.26204
ZNF692 zinc finger protein 692 -2.26065
EPHA5 EPH receptor A5 -2.25461
RGS2 regulator of G-protein signaling 2 -2.25295
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -2.24376
RBM15 RNA binding motif protein 15 -2.24279
BYSL bystin-like -2.23496
GOLGA8A golgin A8 family, member A -2.20165
RFC2 replication factor C (activator 1) 2, 40kDa -2.19352
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.1934
UBC ubiquitin C -2.18736
TOR1A torsin family 1, member A (torsin A) -2.18438
HOPX HOP homeobox -2.18106
ZNF140 zinc finger protein 140 -2.17644
EGR1 early growth response 1 -2.17154
CERT1 ceramide transporter 1 -2.17134
LRRC2 leucine rich repeat containing 2 -2.16499
RGS4 regulator of G-protein signaling 4 -2.16489
UBA2 ubiquitin-like modifier activating enzyme 2 -2.16456
POLR1D polymerase (RNA) I polypeptide D, 16kDa -2.16403
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.16127
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -2.15949
HSPA1B heat shock 70kDa protein 1B -2.15731
CLTB clathrin, light chain B -2.14708
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -2.14552
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.14057
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -2.13713
TMEM147 transmembrane protein 147 -2.13641
INSIG2 insulin induced gene 2 -2.13638
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -2.1203
TTC13 tetratricopeptide repeat domain 13 -2.11855
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -2.11654
USP6NL USP6 N-terminal like -2.11255
PUS7 pseudouridylate synthase 7 (putative) -2.11228
CERK ceramide kinase -2.09507
THOC7 THO complex 7 -2.09435
FGF14 fibroblast growth factor 14 -2.08394
ADAMDEC1 ADAM-like, decysin 1 -2.07938
TNPO1 transportin 1 -2.07499
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -2.07211
NCK2 NCK adaptor protein 2 -2.06995
RPS15A ribosomal protein S15a -2.06675
ILK integrin-linked kinase -2.06653
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) -2.06383
PAEP progestagen-associated endometrial protein -2.06331
SCFD1 sec1 family domain containing 1 -2.06076
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -2.05303
RAB33A RAB33A, member RAS oncogene family -2.04807
NCAPG2 non-SMC condensin II complex, subunit G2 -2.04755
RPP40 ribonuclease P/MRP 40kDa subunit -2.04169
FN1 fibronectin 1 -2.03726
PEA15 phosphoprotein enriched in astrocytes 15 -2.03136
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.03077
HLA-A major histocompatibility complex, class I, A -2.02516
GLRB glycine receptor, beta -2.02446
MOGS mannosyl-oligosaccharide glucosidase -2.0243
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.02114
PYY peptide YY -2.01181
SLC35A5 solute carrier family 35, member A5 -2.01174
ATRAID all-trans retinoic acid-induced differentiation factor -2.00591
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -2.00383
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.00051