CRCGN009_HEPG2_24H:L16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethinyl estradiol 4.97 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN009_HEPG2_24H:L16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EPHB2 EPH receptor B2 6.19055
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.62724
NOTCH1 notch 1 4.55934
CYCS cytochrome c, somatic 3.62291
SFTPB surfactant protein B 3.21271
TIAM1 T-cell lymphoma invasion and metastasis 1 3.13198
ABHD6 abhydrolase domain containing 6 3.0946
CHN1 chimerin 1 3.04659
HEBP1 heme binding protein 1 2.84984
DIPK1A divergent protein kinase domain 1A 2.79761
SNAP25 synaptosomal-associated protein, 25kDa 2.30831
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.26489
DYNLT3 dynein, light chain, Tctex-type 3 2.20135
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.13362
ISG15 ISG15 ubiquitin-like modifier 2.11983
KLHL21 kelch-like family member 21 2.08183
NCOA6 nuclear receptor coactivator 6 2.07842
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.04204

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.61334
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.94919
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.89991
MRPS2 mitochondrial ribosomal protein S2 -4.84544
LDHD lactate dehydrogenase D -4.78454
CCNB2 cyclin B2 -4.37542
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.21224
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.19814
PLK1 polo-like kinase 1 -3.54926
COG7 component of oligomeric golgi complex 7 -3.42358
CDC20 cell division cycle 20 -3.36785
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.98287
ZNF586 zinc finger protein 586 -2.95443
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.82937
DERA deoxyribose-phosphate aldolase (putative) -2.79214
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.55494
TLR4 toll-like receptor 4 -2.51633
UBFD1 ubiquitin family domain containing 1 -2.35806
ACAA1 acetyl-CoA acyltransferase 1 -2.26294
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.23944
TSPAN1 tetraspanin 1 -2.22392
MSMB microseminoprotein, beta- -2.20691
KIF22 kinesin family member 22 -2.1803
CSK c-src tyrosine kinase -2.16743
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.14719
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -2.11469
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.09793
COG2 component of oligomeric golgi complex 2 -2.09714
GNLY granulysin -2.09227
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 -2.07981
METTL9 methyltransferase like 9 -2.07346
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.06623
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.04618
PTPN21 protein tyrosine phosphatase, non-receptor type 21 -2.04477
NKG7 natural killer cell granule protein 7 -2.00653
RAB3B RAB3B, member RAS oncogene family -2.00162