CRCGN009_HEPG2_24H:L18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethinyl estradiol 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN009_HEPG2_24H:L18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.82909
LCN2 lipocalin 2 5.3843
CIAO3 cytosolic iron-sulfur assembly component 3 5.07854
LPAR2 lysophosphatidic acid receptor 2 4.58647
CAPN1 calpain 1, (mu/I) large subunit 4.42695
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.31779
C2CD2 C2 calcium-dependent domain containing 2 4.27174
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.21765
ATP11B ATPase, class VI, type 11B 3.32401
HDGFL3 HDGF like 3 3.22685
MAP7 microtubule-associated protein 7 3.16529
TIAM1 T-cell lymphoma invasion and metastasis 1 3.11317
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.0101
GPATCH8 G patch domain containing 8 2.80006
RXYLT1 ribitol xylosyltransferase 1 2.75476
H2BC12 H2B clustered histone 12 2.69919
CCL2 chemokine (C-C motif) ligand 2 2.6054
PRR15L proline rich 15-like 2.59494
RPA3 replication protein A3, 14kDa 2.56062
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.44062
DSG3 desmoglein 3 2.36409
DUOX2 dual oxidase 2 2.35535
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.30721
PLXDC2 plexin domain containing 2 2.27239
EVL Enah/Vasp-like 2.27167
ANO1 anoctamin 1, calcium activated chloride channel 2.2429
CCNF cyclin F 2.22045
RPL26L1 ribosomal protein L26-like 1 2.18266
TECR trans-2,3-enoyl-CoA reductase 2.02774
DEFA3 defensin, alpha 3, neutrophil-specific 2.01386

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -8.95768
OXA1L oxidase (cytochrome c) assembly 1-like -6.64748
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.58163
PCNA proliferating cell nuclear antigen -5.25553
ZNF586 zinc finger protein 586 -5.1795
CD320 CD320 molecule -4.74768
VAT1 vesicle amine transport 1 -4.52751
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.50606
TRIB3 tribbles pseudokinase 3 -4.48389
PRPF4 pre-mRNA processing factor 4 -4.45147
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.45096
TSPAN4 tetraspanin 4 -4.21042
C2CD5 C2 calcium-dependent domain containing 5 -4.14211
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.03701
CCNB2 cyclin B2 -4.00116
TLR4 toll-like receptor 4 -3.97375
CDC25B cell division cycle 25B -3.96727
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.5091
SNX11 sorting nexin 11 -3.38024
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.37225
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.27129
CD58 CD58 molecule -3.10442
EIF5 eukaryotic translation initiation factor 5 -2.93504
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -2.53875
ZNF551 zinc finger protein 551 -2.47589
SLC35F2 solute carrier family 35, member F2 -2.34119
HSPA8 heat shock 70kDa protein 8 -2.28685
ZSCAN26 zinc finger and SCAN domain containing 26 -2.15658
FBXL6 F-box and leucine-rich repeat protein 6 -2.11256
NRIP1 nuclear receptor interacting protein 1 -2.09929
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.09615
STX4 syntaxin 4 -2.0799
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.07076
ZNF304 zinc finger protein 304 -2.05704
BFSP1 beaded filament structural protein 1, filensin -2.03445
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.0275
TTC19 tetratricopeptide repeat domain 19 -2.01549
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 -2.00244