CRCGN009_HEPG2_24H:L20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorphenamine 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN009_HEPG2_24H:L20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 9.32471
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.8351
SRC SRC proto-oncogene, non-receptor tyrosine kinase 5.34287
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.27889
RPL39L ribosomal protein L39-like 5.20234
DYNLT3 dynein, light chain, Tctex-type 3 5.19794
PPARG peroxisome proliferator-activated receptor gamma 5.14908
MAMLD1 mastermind-like domain containing 1 4.58553
ATP11B ATPase, class VI, type 11B 4.53881
MAP7 microtubule-associated protein 7 4.04007
CCL2 chemokine (C-C motif) ligand 2 3.6161
MEST mesoderm specific transcript 3.37548
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.28554
MICALL1 MICAL-like 1 3.24489
PRR15L proline rich 15-like 2.91694
GSTZ1 glutathione S-transferase zeta 1 2.83146
SFTPB surfactant protein B 2.81428
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.59117
CD40 CD40 molecule, TNF receptor superfamily member 5 2.56545
CHEK2 checkpoint kinase 2 2.46226
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.45509
PCDHB11 protocadherin beta 11 2.42905
NGF nerve growth factor (beta polypeptide) 2.41682
CCNA1 cyclin A1 2.34656
MAST2 microtubule associated serine/threonine kinase 2 2.32413
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.3067
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.29385
SYNPO2 synaptopodin 2 2.2931
TBXA2R thromboxane A2 receptor 2.28477
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.284
ITGA8 integrin, alpha 8 2.27158
GPRIN2 G protein regulated inducer of neurite outgrowth 2 2.27117
EPHA3 EPH receptor A3 2.26615
TRAM2 translocation associated membrane protein 2 2.25868
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.23066
UFM1 ubiquitin-fold modifier 1 2.22519
ARL2BP ADP-ribosylation factor-like 2 binding protein 2.20007
CCNF cyclin F 2.10173
LYZL6 lysozyme-like 6 2.08859
SIRT6 sirtuin 6 2.08128
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 2.06365
PLAT plasminogen activator, tissue 2.06089
RSRC1 arginine/serine-rich coiled-coil 1 2.04715
SH2B2 SH2B adaptor protein 2 2.0457
SPRED2 sprouty-related, EVH1 domain containing 2 2.04089
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.03038
LDAF1 lipid droplet assembly factor 1 2.02571
ENAH enabled homolog (Drosophila) 2.01215
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.00995

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -9.37676
ZDHHC6 zinc finger, DHHC-type containing 6 -5.52569
CDC20 cell division cycle 20 -5.33381
VAT1 vesicle amine transport 1 -4.75088
PCNA proliferating cell nuclear antigen -4.43646
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.2291
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.99519
TM9SF3 transmembrane 9 superfamily member 3 -3.70861
GNAS GNAS complex locus -3.58485
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.54215
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.53347
DERA deoxyribose-phosphate aldolase (putative) -3.522
OXA1L oxidase (cytochrome c) assembly 1-like -3.46497
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.43608
ZNF586 zinc finger protein 586 -3.22804
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.21549
CDC25B cell division cycle 25B -2.94874
CHEK1 checkpoint kinase 1 -2.76688
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.68893
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.63613
ACAA1 acetyl-CoA acyltransferase 1 -2.55375
GORASP1 golgi reassembly stacking protein 1, 65kDa -2.53878
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.45602
ITGB1BP1 integrin beta 1 binding protein 1 -2.36413
HLA-A major histocompatibility complex, class I, A -2.33601
SETD3 SET domain containing 3 -2.24268
SAV1 salvador family WW domain containing protein 1 -2.23688
TWF2 twinfilin actin binding protein 2 -2.22257
HLA-C major histocompatibility complex, class I, C -2.19731
CAB39 calcium binding protein 39 -2.14157
ASXL2 additional sex combs like transcriptional regulator 2 -2.11848
PRPF4 pre-mRNA processing factor 4 -2.1144
CFAP20 cilia and flagella associated protein 20 -2.02687
EIPR1 EARP complex and GARP complex interacting protein 1 -2.00767