CRCGN009_HEPG2_24H:L21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorphenamine 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN009_HEPG2_24H:L21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 6.05921
TIAM1 T-cell lymphoma invasion and metastasis 1 5.71102
PHKG2 phosphorylase kinase, gamma 2 (testis) 5.05967
STIMATE STIM activating enhancer 4.89138
ADRB2 adrenoceptor beta 2, surface 4.76649
EVL Enah/Vasp-like 4.60715
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.54468
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.50198
E2F2 E2F transcription factor 2 4.38989
UBQLN2 ubiquilin 2 4.30874
CIAO3 cytosolic iron-sulfur assembly component 3 4.01556
SNAP25 synaptosomal-associated protein, 25kDa 3.91118
MELK maternal embryonic leucine zipper kinase 3.82717
CCL2 chemokine (C-C motif) ligand 2 3.77596
CBR3 carbonyl reductase 3 3.77236
AMDHD2 amidohydrolase domain containing 2 3.7425
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.67478
TAC4 tachykinin 4 (hemokinin) 3.19712
GPATCH8 G patch domain containing 8 2.98049
RXYLT1 ribitol xylosyltransferase 1 2.81638
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.73653
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.69035
PLSCR1 phospholipid scramblase 1 2.63661
KDM5A lysine (K)-specific demethylase 5A 2.63547
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.27337
CRNN cornulin 2.18287
SPRR3 small proline-rich protein 3 2.1502
DCP2 decapping mRNA 2 2.05843
HAMP hepcidin antimicrobial peptide 2.05397
FGG fibrinogen gamma chain 2.02226
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 2.01364
TMPRSS11D transmembrane protease, serine 11D 2.00758

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.40977
TLR4 toll-like receptor 4 -7.3417
OXA1L oxidase (cytochrome c) assembly 1-like -7.03826
DNM1L dynamin 1-like -5.27037
PCNA proliferating cell nuclear antigen -5.09594
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -5.03157
TRIB3 tribbles pseudokinase 3 -4.43077
CCNB1 cyclin B1 -4.22957
CDC20 cell division cycle 20 -3.84304
MAPK13 mitogen-activated protein kinase 13 -3.74261
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.72071
FGFR4 fibroblast growth factor receptor 4 -3.44092
PRPF4 pre-mRNA processing factor 4 -3.22492
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.21158
DERA deoxyribose-phosphate aldolase (putative) -3.19822
GIPC2 GIPC PDZ domain containing family, member 2 -3.14991
EGF epidermal growth factor -3.00162
FABP2 fatty acid binding protein 2, intestinal -2.95727
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.88378
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.85356
EFHD1 EF-hand domain family, member D1 -2.72429
FAT4 FAT atypical cadherin 4 -2.66106
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.59983
NVL nuclear VCP-like -2.59427
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -2.47694
SUGCT succinyl-CoA:glutarate-CoA transferase -2.47093
MYOG myogenin (myogenic factor 4) -2.4373
CLCA1 chloride channel accessory 1 -2.39005
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.34113
PDGFD platelet derived growth factor D -2.32609
SCN4A sodium channel, voltage gated, type IV alpha subunit -2.32409
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 -2.32243
DAAM2 dishevelled associated activator of morphogenesis 2 -2.29424
SOCS4 suppressor of cytokine signaling 4 -2.2815
KLK1 kallikrein 1 -2.28057
MUC2 mucin 2, oligomeric mucus/gel-forming -2.26584
DOCK5 dedicator of cytokinesis 5 -2.24164
CEP112 centrosomal protein 112kDa -2.22991
NID1 nidogen 1 -2.21634
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 -2.2139
ADGRD2 adhesion G protein-coupled receptor D2 -2.20329
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.19171
HHLA2 HERV-H LTR-associating 2 -2.1835
MYO1D myosin ID -2.17313
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa -2.16737
EMCN endomucin -2.15905
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.15295
PTPRB protein tyrosine phosphatase, receptor type, B -2.14443
SPRYD7 SPRY domain containing 7 -2.12551
PLVAP plasmalemma vesicle associated protein -2.12131
TRAPPC6A trafficking protein particle complex 6A -2.09942
TMC7 transmembrane channel-like 7 -2.09409
ITGA9 integrin, alpha 9 -2.07973
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -2.066
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.06334
GPR162 G protein-coupled receptor 162 -2.05727
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -2.03769
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 -2.03339
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.031
MYBPC2 myosin binding protein C, fast type -2.02867
LMAN1 lectin, mannose-binding, 1 -2.02786
HPCAL4 hippocalcin like 4 -2.02731
PTPRK protein tyrosine phosphatase, receptor type, K -2.02637
HNF4G hepatocyte nuclear factor 4, gamma -2.02467
RNF186 ring finger protein 186 -2.02198
IQCC IQ motif containing C -2.01978
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled -2.00989