CRCGN009_HEPG2_24H:L24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorphenamine 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN009_HEPG2_24H:L24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 6.88961
ABHD6 abhydrolase domain containing 6 5.05426
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.25146
CXCL2 chemokine (C-X-C motif) ligand 2 3.8341
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.69317
SIRT3 sirtuin 3 3.47642
RPL39L ribosomal protein L39-like 3.43964
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.30786
SFTPB surfactant protein B 3.25939
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.23928
HLA-DMA major histocompatibility complex, class II, DM alpha 3.21959
GPER1 G protein-coupled estrogen receptor 1 3.10629
STIMATE STIM activating enhancer 3.09911
ADRB2 adrenoceptor beta 2, surface 3.09523
HOXA10 homeobox A10 3.09174
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.98818
UBQLN2 ubiquilin 2 2.95914
ZNF589 zinc finger protein 589 2.83795
PPARG peroxisome proliferator-activated receptor gamma 2.68904
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.62912
CHMP6 charged multivesicular body protein 6 2.61385
PFKL phosphofructokinase, liver 2.56063
KIF20A kinesin family member 20A 2.55041
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.52547
SNAP25 synaptosomal-associated protein, 25kDa 2.42573
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.32433
MAP7 microtubule-associated protein 7 2.3142
GARRE1 granule associated Rac and RHOG effector 1 2.30185
TRMT61B tRNA methyltransferase 61B 2.26039
CYCS cytochrome c, somatic 2.22539
CIAO3 cytosolic iron-sulfur assembly component 3 2.19597
CGRRF1 cell growth regulator with ring finger domain 1 2.18626
JADE2 jade family PHD finger 2 2.17471
TIAM1 T-cell lymphoma invasion and metastasis 1 2.14161

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
TLR4 toll-like receptor 4 -5.47328
CDC20 cell division cycle 20 -3.95515
PRCP prolylcarboxypeptidase (angiotensinase C) -3.61718
VAT1 vesicle amine transport 1 -3.55991
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.46094
TMEM109 transmembrane protein 109 -3.38396
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.35356
EGF epidermal growth factor -3.33365
TSPAN4 tetraspanin 4 -3.27306
FBXL12 F-box and leucine-rich repeat protein 12 -3.19599
DNM1L dynamin 1-like -3.04828
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.87014
FGFR4 fibroblast growth factor receptor 4 -2.58635
TRAP1 TNF receptor-associated protein 1 -2.53749
NRIP1 nuclear receptor interacting protein 1 -2.47765
CCNB2 cyclin B2 -2.4595
DDIT4 DNA-damage-inducible transcript 4 -2.45905
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.37984
GNAS GNAS complex locus -2.34273
GPR65 G protein-coupled receptor 65 -2.26724
CRTAM cytotoxic and regulatory T cell molecule -2.20138
RAI2 retinoic acid induced 2 -2.1242
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -2.04398
OXA1L oxidase (cytochrome c) assembly 1-like -2.03677
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.0225