CRCGN009_HEPG2_24H:M03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description di(2-ethylhexyl)phthalate 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN009_HEPG2_24H:M03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 5.95953
MAP7 microtubule-associated protein 7 4.58066
PPARG peroxisome proliferator-activated receptor gamma 4.4373
KLHL21 kelch-like family member 21 4.32557
CARMIL1 capping protein regulator and myosin 1 linker 1 3.64623
E2F2 E2F transcription factor 2 3.57101
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.5409
DIPK1A divergent protein kinase domain 1A 3.41913
PLSCR1 phospholipid scramblase 1 3.25178
CCL2 chemokine (C-C motif) ligand 2 3.05551
GPER1 G protein-coupled estrogen receptor 1 3.04536
GSTZ1 glutathione S-transferase zeta 1 2.89333
GATA2 GATA binding protein 2 2.47137
SFTPB surfactant protein B 2.45294
CNPY3 canopy FGF signaling regulator 3 2.43348
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.37664
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.35963
JADE2 jade family PHD finger 2 2.29515
PLSCR3 phospholipid scramblase 3 2.253
CCNF cyclin F 2.16546
PTK2 protein tyrosine kinase 2 2.15752
ZFP36 ZFP36 ring finger protein 2.12799

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.7139
ZDHHC6 zinc finger, DHHC-type containing 6 -4.58301
NGRN neugrin, neurite outgrowth associated -4.43265
ZNF586 zinc finger protein 586 -4.28399
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.16008
C2CD5 C2 calcium-dependent domain containing 5 -4.14009
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.11568
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.06936
PUF60 poly-U binding splicing factor 60KDa -4.0632
CDC20 cell division cycle 20 -3.95099
LDHD lactate dehydrogenase D -3.95088
RGS2 regulator of G-protein signaling 2 -3.90062
PCNA proliferating cell nuclear antigen -3.87948
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.80632
ADI1 acireductone dioxygenase 1 -3.75273
FBXL12 F-box and leucine-rich repeat protein 12 -3.6785
SCRIB scribbled planar cell polarity protein -2.97264
ZMIZ1 zinc finger, MIZ-type containing 1 -2.76686
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.75418
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.63552
MACF1 microtubule-actin crosslinking factor 1 -2.54543
MICU2 mitochondrial calcium uptake 2 -2.31899
NRIP1 nuclear receptor interacting protein 1 -2.22517
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.21102
NVL nuclear VCP-like -2.05574
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.03579
HYOU1 hypoxia up-regulated 1 -2.00638