CRCGN009_HEPG2_24H:M04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description di(2-ethylhexyl)phthalate 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

82 genes differentially expressed following the CRCGN009_HEPG2_24H:M04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 6.25742
HLA-DMA major histocompatibility complex, class II, DM alpha 5.57257
AMDHD2 amidohydrolase domain containing 2 5.36821
GATA3 GATA binding protein 3 5.24932
STIMATE STIM activating enhancer 4.98234
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.96765
GPER1 G protein-coupled estrogen receptor 1 4.65626
EPHB2 EPH receptor B2 4.28412
ABHD6 abhydrolase domain containing 6 3.80358
CYCS cytochrome c, somatic 3.62749
HEBP1 heme binding protein 1 3.4373
MAP7 microtubule-associated protein 7 3.22227
JADE2 jade family PHD finger 2 3.22161
E2F2 E2F transcription factor 2 3.17239
TATDN2 TatD DNase domain containing 2 2.95218
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.93932
ADGRE5 adhesion G protein-coupled receptor E5 2.93096
GSTZ1 glutathione S-transferase zeta 1 2.8804
RPL39L ribosomal protein L39-like 2.85949
NOSIP nitric oxide synthase interacting protein 2.84255
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.70909
DIPK1A divergent protein kinase domain 1A 2.69804
LSR lipolysis stimulated lipoprotein receptor 2.49539
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2.47993
MMP13 matrix metallopeptidase 13 2.43198
WDR76 WD repeat domain 76 2.40915
NUCB2 nucleobindin 2 2.28005
STK10 serine/threonine kinase 10 2.24543
MTA2 metastasis associated 1 family, member 2 2.24415
THRAP3 thyroid hormone receptor associated protein 3 2.24126
LIME1 Lck interacting transmembrane adaptor 1 2.24096
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.23714
GRTP1 growth hormone regulated TBC protein 1 2.23446
CEPT1 choline/ethanolamine phosphotransferase 1 2.1925
AKT2 v-akt murine thymoma viral oncogene homolog 2 2.18491
EPYC epiphycan 2.17334
HDGFL3 HDGF like 3 2.17062
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.16916
MEF2C myocyte enhancer factor 2C 2.16867
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.14606
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.14371
LHX5 LIM homeobox 5 2.13081
CCNE2 cyclin E2 2.11633
MTSS2 MTSS I-BAR domain containing 2 2.10524
PDCD1 programmed cell death 1 2.10283
STAT2 signal transducer and activator of transcription 2, 113kDa 2.09985
LOC124900193 uncharacterized LOC124900193 2.06983
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2.05827
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.05558
PCDHA10 protocadherin alpha 10 2.04993
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.03794
RNASE12 ribonuclease, RNase A family, 12 (non-active) 2.02474
LBX1 ladybird homeobox 1 2.01399
CCNF cyclin F 2.00706
LCN2 lipocalin 2 2.00268
CRYGC crystallin, gamma C 2.00102

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -7.71464
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -7.18028
PCNA proliferating cell nuclear antigen -7.02755
CCNB2 cyclin B2 -5.5129
VAT1 vesicle amine transport 1 -5.40181
CDC20 cell division cycle 20 -4.83159
NGRN neugrin, neurite outgrowth associated -4.72192
SPAG4 sperm associated antigen 4 -4.07692
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.82941
NRIP1 nuclear receptor interacting protein 1 -3.26085
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.96727
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.84959
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.76822
SNX11 sorting nexin 11 -2.76578
FASTKD5 FAST kinase domains 5 -2.74561
NT5DC2 5'-nucleotidase domain containing 2 -2.51868
SEC24C SEC24 family member C -2.44602
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.42771
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.41213
SMNDC1 survival motor neuron domain containing 1 -2.27473
CHIC2 cysteine-rich hydrophobic domain 2 -2.25263
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.17205
WASHC4 WASH complex subunit 4 -2.16307
CSK c-src tyrosine kinase -2.12386
SLC35F2 solute carrier family 35, member F2 -2.04324
AKAP8 A kinase (PRKA) anchor protein 8 -2.01829