CRCGN009_HEPG2_24H:M05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description di(2-ethylhexyl)phthalate 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

81 genes differentially expressed following the CRCGN009_HEPG2_24H:M05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 8.03562
CYCS cytochrome c, somatic 7.41199
CBR3 carbonyl reductase 3 6.22082
RPP38 ribonuclease P/MRP 38kDa subunit 6.05436
CCL2 chemokine (C-C motif) ligand 2 6.01283
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.61629
CHMP6 charged multivesicular body protein 6 5.13142
E2F2 E2F transcription factor 2 5.11931
C2CD2 C2 calcium-dependent domain containing 2 5.07358
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.89035
MAP7 microtubule-associated protein 7 4.2989
LCN2 lipocalin 2 4.00763
PPARG peroxisome proliferator-activated receptor gamma 3.9569
MEF2C myocyte enhancer factor 2C 3.91534
TATDN2 TatD DNase domain containing 2 3.78506
HOXA10 homeobox A10 3.76373
AMDHD2 amidohydrolase domain containing 2 3.67288
UBQLN2 ubiquilin 2 3.61334
STK10 serine/threonine kinase 10 3.59279
CXCR4 chemokine (C-X-C motif) receptor 4 3.50502
GSTZ1 glutathione S-transferase zeta 1 3.50275
ADGRE5 adhesion G protein-coupled receptor E5 3.44069
GPER1 G protein-coupled estrogen receptor 1 3.43311
HDGFL3 HDGF like 3 3.13492
CHN1 chimerin 1 3.11547
ALDOC aldolase C, fructose-bisphosphate 3.0604
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.96046
ZNF589 zinc finger protein 589 2.95284
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.9192
SH3D19 SH3 domain containing 19 2.49558
DENND2D DENN/MADD domain containing 2D 2.43108
MYBPH myosin binding protein H 2.41164
ZFP36 ZFP36 ring finger protein 2.3129
RPL39L ribosomal protein L39-like 2.29051
MEST mesoderm specific transcript 2.26426
MYLK myosin light chain kinase 2.22972
BANP BTG3 associated nuclear protein 2.20861
NOTCH1 notch 1 2.18015
HLA-DMA major histocompatibility complex, class II, DM alpha 2.11648
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.10758
IGHMBP2 immunoglobulin mu binding protein 2 2.09477
CKM creatine kinase, muscle 2.09051
CHRDL1 chordin-like 1 2.07645
FCHO1 FCH domain only 1 2.07253
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.06846
GARRE1 granule associated Rac and RHOG effector 1 2.05092
ACTA1 actin, alpha 1, skeletal muscle 2.01999
SMPX small muscle protein, X-linked 2.00035

decreased expression

Symbol Name Standardized Value
CAB39 calcium binding protein 39 -5.35859
LDHD lactate dehydrogenase D -5.24132
TLR4 toll-like receptor 4 -4.97092
OXA1L oxidase (cytochrome c) assembly 1-like -4.96288
UBE3C ubiquitin protein ligase E3C -4.44602
CDC25B cell division cycle 25B -4.42152
TCTN1 tectonic family member 1 -4.41755
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.32989
CSK c-src tyrosine kinase -4.20917
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.18507
NGRN neugrin, neurite outgrowth associated -3.86649
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.65427
PCNA proliferating cell nuclear antigen -3.62049
TXNDC9 thioredoxin domain containing 9 -3.47692
SNX11 sorting nexin 11 -3.46934
SLC35F2 solute carrier family 35, member F2 -3.20627
MRPS2 mitochondrial ribosomal protein S2 -3.10703
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.8331
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.56893
HOXC4 homeobox C4 -2.50201
EGF epidermal growth factor -2.28756
CRTAP cartilage associated protein -2.20259
HEATR1 HEAT repeat containing 1 -2.19749
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.14585
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -2.11787
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1106
PEX11B peroxisomal biogenesis factor 11 beta -2.07396
NANOS3 nanos homolog 3 (Drosophila) -2.05865
CTNND1 catenin (cadherin-associated protein), delta 1 -2.04343
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.02233
GCA grancalcin, EF-hand calcium binding protein -2.01149
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.00448
ZNF318 zinc finger protein 318 -2.00009