CRCGN009_HEPG2_24H:M06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description di(2-ethylhexyl)phthalate 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN009_HEPG2_24H:M06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 9.17317
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.61501
CHMP6 charged multivesicular body protein 6 4.51096
GPATCH8 G patch domain containing 8 4.39741
PPARG peroxisome proliferator-activated receptor gamma 4.36153
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.21379
PRKCH protein kinase C, eta 3.81807
FZD7 frizzled class receptor 7 3.5247
ANO1 anoctamin 1, calcium activated chloride channel 3.32696
GSTZ1 glutathione S-transferase zeta 1 2.79213
DHDDS dehydrodolichyl diphosphate synthase 2.74306
GATA2 GATA binding protein 2 2.59567
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.49521
JADE2 jade family PHD finger 2 2.47371
CST1 cystatin SN 2.44076
ZNF589 zinc finger protein 589 2.43099
SLC38A10 solute carrier family 38, member 10 2.36662
PPP1R26 protein phosphatase 1, regulatory subunit 26 2.36081
TNIP1 TNFAIP3 interacting protein 1 2.32829
SFTPB surfactant protein B 2.27254
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.22316
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.17798
AXIN1 axin 1 2.14982
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.14272
STRADA STE20-related kinase adaptor alpha 2.13424
NPDC1 neural proliferation, differentiation and control, 1 2.11676
CST2 cystatin SA 2.06977
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.02565

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.35578
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.9608
CD320 CD320 molecule -4.83185
COG2 component of oligomeric golgi complex 2 -4.58999
PCNA proliferating cell nuclear antigen -4.57217
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.33789
C2CD5 C2 calcium-dependent domain containing 5 -4.29081
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.85956
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -3.22543
OXA1L oxidase (cytochrome c) assembly 1-like -3.17405
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.05421
NGRN neugrin, neurite outgrowth associated -3.04536
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.96103
HMG20B high mobility group 20B -2.90574
ACAA1 acetyl-CoA acyltransferase 1 -2.58641
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.58445
ITGB1BP1 integrin beta 1 binding protein 1 -2.50748
WASHC4 WASH complex subunit 4 -2.48596
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.45404
TXNDC9 thioredoxin domain containing 9 -2.33954
CEP83 centrosomal protein 83kDa -2.29695
SSBP2 single-stranded DNA binding protein 2 -2.26208
PRPF4 pre-mRNA processing factor 4 -2.25434
CXCL2 chemokine (C-X-C motif) ligand 2 -2.13075
MRPL42 mitochondrial ribosomal protein L42 -2.02648
UFSP2 UFM1-specific peptidase 2 -2.00774