CRCGN009_HEPG2_24H:M08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazobenzene 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN009_HEPG2_24H:M08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 6.14492
ADRB2 adrenoceptor beta 2, surface 4.92304
TIAM1 T-cell lymphoma invasion and metastasis 1 4.81502
CYCS cytochrome c, somatic 3.90864
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.64994
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.47624
ABHD6 abhydrolase domain containing 6 3.47143
KIF5C kinesin family member 5C 3.04268
MEST mesoderm specific transcript 2.8557
KLHL9 kelch-like family member 9 2.80099
STIMATE STIM activating enhancer 2.75401
LOC122526780 uncharacterized LOC122526780 2.55177
GARRE1 granule associated Rac and RHOG effector 1 2.42501
NUP133 nucleoporin 133kDa 2.30963
GRWD1 glutamate-rich WD repeat containing 1 2.30415
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.24434
TBPL1 TBP-like 1 2.17246

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -7.16925
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.28032
PECR peroxisomal trans-2-enoyl-CoA reductase -5.21418
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.98145
NRIP1 nuclear receptor interacting protein 1 -4.3951
TLR4 toll-like receptor 4 -4.28988
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.61457
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.44071
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -3.39579
RFC2 replication factor C (activator 1) 2, 40kDa -3.21053
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.99697
CPNE3 copine III -2.49249
FHL2 four and a half LIM domains 2 -2.48795
LAP3 leucine aminopeptidase 3 -2.45202
PLA2G15 phospholipase A2, group XV -2.40662
VCY1B variable charge, Y-linked 1B -2.16844
FSCN3 fascin actin-bundling protein 3, testicular -2.15428
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.14408
DCK deoxycytidine kinase -2.13419
SNX11 sorting nexin 11 -2.12282
GRK1 G protein-coupled receptor kinase 1 -2.06676
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.05858
HOXA5 homeobox A5 -2.00908
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.00688