CRCGN009_HEPG2_24H:M12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazobenzene 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN009_HEPG2_24H:M12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.95663
DYNLT3 dynein, light chain, Tctex-type 3 4.75765
CBR3 carbonyl reductase 3 4.74045
HLA-DMA major histocompatibility complex, class II, DM alpha 4.46169
STK10 serine/threonine kinase 10 4.22126
E2F2 E2F transcription factor 2 4.12606
CIAO3 cytosolic iron-sulfur assembly component 3 4.08826
BACE2 beta-site APP-cleaving enzyme 2 4.03165
MOK MOK protein kinase 3.90853
HLA-DRA major histocompatibility complex, class II, DR alpha 3.62442
PFKL phosphofructokinase, liver 3.52697
CEMIP2 cell migration inducing hyaluronidase 2 3.5265
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.42161
HOXA10 homeobox A10 3.38508
MAP7 microtubule-associated protein 7 3.34633
TAC4 tachykinin 4 (hemokinin) 3.04494
CCNF cyclin F 3.02584
CXCL2 chemokine (C-X-C motif) ligand 2 2.96743
TEX10 testis expressed 10 2.96325
JADE2 jade family PHD finger 2 2.88901
PRKCH protein kinase C, eta 2.87097
EPHB2 EPH receptor B2 2.82092
ABHD6 abhydrolase domain containing 6 2.78255
GATA2 GATA binding protein 2 2.72053
GPATCH8 G patch domain containing 8 2.64401
TBP TATA box binding protein 2.62928
HEBP2 heme binding protein 2 2.47579
NSD1 nuclear receptor binding SET domain protein 1 2.41735
CHN1 chimerin 1 2.39686
COL9A1 collagen, type IX, alpha 1 2.37615
BAMBI BMP and activin membrane-bound inhibitor 2.37415
GPER1 G protein-coupled estrogen receptor 1 2.34418
HYOU1 hypoxia up-regulated 1 2.33976
AGBL5 ATP/GTP binding protein-like 5 2.3108
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.30181
EVL Enah/Vasp-like 2.22962
SIX6 SIX homeobox 6 2.22334
CETN3 centrin, EF-hand protein, 3 2.18699
ATOX1 antioxidant 1 copper chaperone 2.17526
DEFA6 defensin, alpha 6, Paneth cell-specific 2.17217
COX17 COX17 cytochrome c oxidase copper chaperone 2.16835
TREH trehalase (brush-border membrane glycoprotein) 2.15836
HOXB9 homeobox B9 2.14577
H3-4 H3.4 histone, cluster member 2.14488
BABAM2 BRISC and BRCA1 A complex member 2 2.10756
AGO4 argonaute RISC catalytic component 4 2.10436
CEP57 centrosomal protein 57kDa 2.06236
ECD ecdysoneless homolog (Drosophila) 2.05723
GATD3 glutamine amidotransferase class 1 domain containing 3 2.03401
FOXH1 forkhead box H1 2.03385
REG1B regenerating islet-derived 1 beta 2.03208
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.02358
WASHC3 WASH complex subunit 3 2.02299
ZBTB22 zinc finger and BTB domain containing 22 2.01936
MRPL30 mitochondrial ribosomal protein L30 2.01434
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.01385

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.46964
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -8.38663
CCNB1 cyclin B1 -7.42903
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.50227
LDHD lactate dehydrogenase D -5.39214
OXA1L oxidase (cytochrome c) assembly 1-like -5.33106
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.76529
TRIB3 tribbles pseudokinase 3 -4.74963
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.65035
COG2 component of oligomeric golgi complex 2 -4.57253
CCNB2 cyclin B2 -4.50737
GOLT1B golgi transport 1B -4.47393
CHMP4B charged multivesicular body protein 4B -4.40301
HAT1 histone acetyltransferase 1 -4.28426
CDC20 cell division cycle 20 -4.16297
KDM3A lysine (K)-specific demethylase 3A -3.9346
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.28363
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.21895
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.68334
TM9SF3 transmembrane 9 superfamily member 3 -2.59653
SLC35F2 solute carrier family 35, member F2 -2.44338
DEXI Dexi homolog (mouse) -2.37657
EIF5 eukaryotic translation initiation factor 5 -2.32934
TLCD3A TLC domain containing 3A -2.32578
MAVS mitochondrial antiviral signaling protein -2.30243
LOXL1 lysyl oxidase-like 1 -2.24409
MYL9 myosin, light chain 9, regulatory -2.17449
CREB3L4 cAMP responsive element binding protein 3-like 4 -2.17314
TGFB3 transforming growth factor, beta 3 -2.12816
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.08131
VIPR1 vasoactive intestinal peptide receptor 1 -2.07726
TM9SF1 transmembrane 9 superfamily member 1 -2.07298
TFRC transferrin receptor -2.04921
ATG101 autophagy related 101 -2.03061