CRCGN009_HEPG2_24H:M13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description [1,1'-biphenyl]-3,3',4,4'-tetramine tetrahydrochloride 19.99 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

144 genes differentially expressed following the CRCGN009_HEPG2_24H:M13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 10.0
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 8.2052
PPARG peroxisome proliferator-activated receptor gamma 5.8364
TXNRD1 thioredoxin reductase 1 5.39835
TCEA2 transcription elongation factor A (SII), 2 5.1991
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.0524
NOTCH1 notch 1 5.0
TMEM109 transmembrane protein 109 4.8162
AMDHD2 amidohydrolase domain containing 2 4.64085
UGDH UDP-glucose 6-dehydrogenase 4.61225
FCHO1 FCH domain only 1 4.58755
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.5784
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.2616
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 4.0486
CYCS cytochrome c, somatic 3.91775
KLHL21 kelch-like family member 21 3.90455
ZFP36 ZFP36 ring finger protein 3.89245
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.83095
CDC45 cell division cycle 45 3.783
LCN2 lipocalin 2 3.77005
CBR1 carbonyl reductase 1 3.54165
LOC122526780 uncharacterized LOC122526780 3.4883
ABHD4 abhydrolase domain containing 4 3.4414
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.32715
GHR growth hormone receptor 3.1535
STXBP1 syntaxin binding protein 1 3.14545
PLD3 phospholipase D family, member 3 3.0795
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.03205
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.99925
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.93525
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.8742
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.86415
MCUR1 mitochondrial calcium uniporter regulator 1 2.85035
RPL39L ribosomal protein L39-like 2.8366
CCL2 chemokine (C-C motif) ligand 2 2.82295
RAB4A RAB4A, member RAS oncogene family 2.79815
CDK6 cyclin-dependent kinase 6 2.68455
DNM1 dynamin 1 2.638
SSRP1 structure specific recognition protein 1 2.57725
OXCT1 3-oxoacid CoA transferase 1 2.50795
F13A1 coagulation factor XIII, A1 polypeptide 2.49785
PHGDH phosphoglycerate dehydrogenase 2.42165
CREB1 cAMP responsive element binding protein 1 2.3858
RFK riboflavin kinase 2.3705
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.32113
MCOLN1 mucolipin 1 2.31455
DIPK1A divergent protein kinase domain 1A 2.31107
LPAR2 lysophosphatidic acid receptor 2 2.2758
ASL argininosuccinate lyase 2.2713
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.2698
CRTAP cartilage associated protein 2.2629
CHN1 chimerin 1 2.2284
SCRN1 secernin 1 2.19585
PLSCR1 phospholipid scramblase 1 2.17205
SORBS3 sorbin and SH3 domain containing 3 2.1257
DPH2 DPH2 homolog (S. cerevisiae) 2.1125
DDIT4 DNA-damage-inducible transcript 4 2.08695
PLTP phospholipid transfer protein 2.05035
DYNLT3 dynein, light chain, Tctex-type 3 2.0327
NUCB1 nucleobindin 1 2.02492
ZNF556 zinc finger protein 556 2.008
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.00615
KEAP1 kelch-like ECH-associated protein 1 2.00425

decreased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -8.0343
NT5DC2 5'-nucleotidase domain containing 2 -6.31635
FBXL12 F-box and leucine-rich repeat protein 12 -6.02075
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.5111
NGRN neugrin, neurite outgrowth associated -5.33725
FASTKD5 FAST kinase domains 5 -5.27595
TLCD3A TLC domain containing 3A -4.9149
ARID5B AT rich interactive domain 5B (MRF1-like) -4.80225
PCNA proliferating cell nuclear antigen -4.7734
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.54355
ZNF586 zinc finger protein 586 -4.5069
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.3285
CCNB1 cyclin B1 -4.03545
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.03487
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.7991
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.7981
WDR7 WD repeat domain 7 -3.7571
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.58045
OXA1L oxidase (cytochrome c) assembly 1-like -3.5474
CAB39 calcium binding protein 39 -3.2211
PDZD2 PDZ domain containing 2 -3.18547
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.0893
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.0704
RPS5 ribosomal protein S5 -3.0179
MYH7 myosin, heavy chain 7, cardiac muscle, beta -3.0057
TCAP titin-cap -2.906
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.78323
RAI14 retinoic acid induced 14 -2.62105
NVL nuclear VCP-like -2.60935
DCAF6 DDB1 and CUL4 associated factor 6 -2.5483
GATA1 GATA binding protein 1 (globin transcription factor 1) -2.546
ANK1 ankyrin 1, erythrocytic -2.52076
CHMP6 charged multivesicular body protein 6 -2.51145
AHSP alpha hemoglobin stabilizing protein -2.502
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -2.481
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -2.4614
KLF1 Kruppel-like factor 1 (erythroid) -2.44515
GSTO1 glutathione S-transferase omega 1 -2.4376
SLC35F2 solute carrier family 35, member F2 -2.43725
PPOX protoporphyrinogen oxidase -2.364
MICALL1 MICAL-like 1 -2.34695
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 -2.33825
TRDN triadin -2.3032
THAP11 THAP domain containing 11 -2.29575
MYH2 myosin, heavy chain 2, skeletal muscle, adult -2.2677
CLCN6 chloride channel, voltage-sensitive 6 -2.2468
RNF123 ring finger protein 123 -2.24655
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 -2.24435
CCS copper chaperone for superoxide dismutase -2.2226
FOS FBJ murine osteosarcoma viral oncogene homolog -2.22175
MTA1 metastasis associated 1 -2.21655
RPL3L ribosomal protein L3-like -2.1859
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.18385
ARID4B AT rich interactive domain 4B (RBP1-like) -2.18335
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -2.1762
GMPPB GDP-mannose pyrophosphorylase B -2.1625
NADSYN1 NAD synthetase 1 -2.14145
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -2.11718
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.10452
TCEAL4 transcription elongation factor A (SII)-like 4 -2.09475
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.09225
UBL5 ubiquitin-like 5 -2.0859
TMOD1 tropomodulin 1 -2.0823
TXNL1 thioredoxin-like 1 -2.0687
SHB Src homology 2 domain containing adaptor protein B -2.06625
MYL2 myosin, light chain 2, regulatory, cardiac, slow -2.06135
RBM15 RNA binding motif protein 15 -2.046
ARID3A AT rich interactive domain 3A (BRIGHT-like) -2.04595
S100A12 S100 calcium binding protein A12 -2.0456
DIPK2B divergent protein kinase domain 2B -2.03155
PYGM phosphorylase, glycogen, muscle -2.02955
UEVLD UEV and lactate/malate dehyrogenase domains -2.02535
TPM3 tropomyosin 3 -2.02525
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) -2.02198
SYTL3 synaptotagmin-like 3 -2.0195
MVD mevalonate (diphospho) decarboxylase -2.015
AMPD1 adenosine monophosphate deaminase 1 -2.01095
MYH1 myosin, heavy chain 1, skeletal muscle, adult -2.0099
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.00605
CA3 carbonic anhydrase III -2.00485
CERK ceramide kinase -2.0023