CRCGN009_HEPG2_24H:M14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description [1,1'-biphenyl]-3,3',4,4'-tetramine tetrahydrochloride 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

149 genes differentially expressed following the CRCGN009_HEPG2_24H:M14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 8.79003
RAI14 retinoic acid induced 14 7.05629
AMDHD2 amidohydrolase domain containing 2 5.13923
UBQLN2 ubiquilin 2 5.11111
LPAR2 lysophosphatidic acid receptor 2 4.72493
EPHB2 EPH receptor B2 4.72314
LCN2 lipocalin 2 4.68833
ADRB2 adrenoceptor beta 2, surface 4.68003
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.92098
TXNRD1 thioredoxin reductase 1 3.85116
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.80471
CHMP6 charged multivesicular body protein 6 3.44564
STXBP2 syntaxin binding protein 2 3.30795
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.27183
HPS4 Hermansky-Pudlak syndrome 4 3.21351
NUCB2 nucleobindin 2 3.08551
E2F2 E2F transcription factor 2 3.07528
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.06498
SNAP25 synaptosomal-associated protein, 25kDa 3.04748
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.93056
DOK3 docking protein 3 2.85029
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.84255
CEP57 centrosomal protein 57kDa 2.82105
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.81444
PRSS22 protease, serine, 22 2.7584
GRM2 glutamate receptor, metabotropic 2 2.6562
A4GALT alpha 1,4-galactosyltransferase 2.63345
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.59145
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.57154
MGMT O-6-methylguanine-DNA methyltransferase 2.56644
MTSS2 MTSS I-BAR domain containing 2 2.53106
TMEM74B transmembrane protein 74B 2.50389
HLA-DRA major histocompatibility complex, class II, DR alpha 2.4936
CNTFR ciliary neurotrophic factor receptor 2.48417
ZNF281 zinc finger protein 281 2.47689
LOC122526780 uncharacterized LOC122526780 2.4724
RCN1 reticulocalbin 1, EF-hand calcium binding domain 2.46141
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.45881
COL11A2 collagen, type XI, alpha 2 2.39685
CRTAP cartilage associated protein 2.39088
PRR15L proline rich 15-like 2.38711
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.38191
COMP cartilage oligomeric matrix protein 2.37724
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.35676
ADM2 adrenomedullin 2 2.3193
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 2.31557
ABHD4 abhydrolase domain containing 4 2.27794
CLDN4 claudin 4 2.27777
SIRT3 sirtuin 3 2.27464
FBXO31 F-box protein 31 2.27441
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 2.27174
GJC2 gap junction protein, gamma 2, 47kDa 2.2593
TCL1B T-cell leukemia/lymphoma 1B 2.24019
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.23492
PF4 platelet factor 4 2.23072
HGFAC HGF activator 2.22811
ANGPT4 angiopoietin 4 2.2244
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.21721
SH2D1A SH2 domain containing 1A 2.21231
KIF25 kinesin family member 25 2.20869
MAT1A methionine adenosyltransferase I, alpha 2.20866
RCN3 reticulocalbin 3, EF-hand calcium binding domain 2.2062
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.20372
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.20145
KANK2 KN motif and ankyrin repeat domains 2 2.1933
JADE2 jade family PHD finger 2 2.19307
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.19212
S1PR4 sphingosine-1-phosphate receptor 4 2.18752
PTGES3 prostaglandin E synthase 3 (cytosolic) 2.17865
AARS1 alanyl-tRNA synthetase 1 2.17582
PAGR1 PAXIP1 associated glutamate-rich protein 1 2.16963
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 2.16676
GPR27 G protein-coupled receptor 27 2.16674
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 2.15937
RHBG Rh family, B glycoprotein (gene/pseudogene) 2.15875
CCNF cyclin F 2.13026
ALX4 ALX homeobox 4 2.12914
IL23A interleukin 23, alpha subunit p19 2.12086
LYRM4 LYR motif containing 4 2.11976
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.11421
UFM1 ubiquitin-fold modifier 1 2.10975
PLD2 phospholipase D2 2.10327
SMCO4 single-pass membrane protein with coiled-coil domains 4 2.10052
FGF6 fibroblast growth factor 6 2.09963
MATN4 matrilin 4 2.09925
VWA7 von Willebrand factor A domain containing 7 2.08398
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.07882
MATN1 matrilin 1, cartilage matrix protein 2.07747
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.07723
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 2.07567
ETNK2 ethanolamine kinase 2 2.07465
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 2.07344
AKAP11 A kinase (PRKA) anchor protein 11 2.07143
RAG1 recombination activating gene 1 2.06013
LDLRAD4 low density lipoprotein receptor class A domain containing 4 2.05627
RAB40C RAB40C, member RAS oncogene family 2.05058
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.05042
CLDN7 claudin 7 2.04961
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.04917
DLX6 distal-less homeobox 6 2.04604
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.03811
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.03523
CD40 CD40 molecule, TNF receptor superfamily member 5 2.02966
GPER1 G protein-coupled estrogen receptor 1 2.02152
CNMD chondromodulin 2.0207
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.02018
AMBP alpha-1-microglobulin/bikunin precursor 2.01107
CRYGC crystallin, gamma C 2.00421
DOT1L DOT1-like histone H3K79 methyltransferase 2.00186

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -8.62158
CCNB2 cyclin B2 -8.28515
TLR4 toll-like receptor 4 -6.51465
PCNA proliferating cell nuclear antigen -5.53327
OXA1L oxidase (cytochrome c) assembly 1-like -5.48721
KDM3A lysine (K)-specific demethylase 3A -5.22108
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -5.20365
LDHD lactate dehydrogenase D -4.91034
VAT1 vesicle amine transport 1 -4.32844
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.25728
YME1L1 YME1-like 1 ATPase -4.05969
CCDC86 coiled-coil domain containing 86 -3.48335
ZNF586 zinc finger protein 586 -3.36169
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.17699
EGF epidermal growth factor -2.8601
TXNDC9 thioredoxin domain containing 9 -2.58407
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.56799
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.41294
TUFT1 tuftelin 1 -2.37047
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.35033
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.33877
GET1 guided entry of tail-anchored proteins factor 1 -2.3195
DDB1 damage-specific DNA binding protein 1, 127kDa -2.26777
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -2.25252
EDN1 endothelin 1 -2.22994
PPOX protoporphyrinogen oxidase -2.20554
CDK17 cyclin-dependent kinase 17 -2.19209
ZNF551 zinc finger protein 551 -2.18375
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.16781
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.15491
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -2.13757
ZNF35 zinc finger protein 35 -2.11495
SLCO4C1 solute carrier organic anion transporter family, member 4C1 -2.09147
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.04744
MAPK13 mitogen-activated protein kinase 13 -2.03107
SAP130 Sin3A-associated protein, 130kDa -2.03001
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -2.00973
CEP112 centrosomal protein 112kDa -2.00676
SPATA7 spermatogenesis associated 7 -2.00129
ZNF394 zinc finger protein 394 -2.00021