| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | [1,1'-biphenyl]-3,3',4,4'-tetramine tetrahydrochloride 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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65 genes differentially expressed following the CRCGN009_HEPG2_24H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 6.38019 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 6.27087 |
| MAP7 | microtubule-associated protein 7 | 4.59114 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 4.02349 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.79198 |
| BZW2 | basic leucine zipper and W2 domains 2 | 3.68558 |
| NOTCH1 | notch 1 | 3.64867 |
| LPAR2 | lysophosphatidic acid receptor 2 | 3.54967 |
| LCN2 | lipocalin 2 | 3.5255 |
| ABHD6 | abhydrolase domain containing 6 | 3.42455 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 3.29829 |
| PLS1 | plastin 1 | 3.12123 |
| EPHA3 | EPH receptor A3 | 3.06516 |
| CYCS | cytochrome c, somatic | 3.06244 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.04561 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 2.99786 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.92178 |
| STIMATE | STIM activating enhancer | 2.82511 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.68267 |
| PRKCH | protein kinase C, eta | 2.64333 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 2.6392 |
| FCHO1 | FCH domain only 1 | 2.63877 |
| MICALL1 | MICAL-like 1 | 2.57708 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.5666 |
| EGF | epidermal growth factor | 2.48583 |
| MCM9 | minichromosome maintenance complex component 9 | 2.31898 |
| SLC25A16 | solute carrier family 25 (mitochondrial carrier), member 16 | 2.28262 |
| TRAK2 | trafficking protein, kinesin binding 2 | 2.27905 |
| CHEK2 | checkpoint kinase 2 | 2.19583 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.18602 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.14501 |
| SNX16 | sorting nexin 16 | 2.10595 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.09944 |
| TSPAN6 | tetraspanin 6 | 2.08887 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -10.0 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -6.20092 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -5.48386 |
| CCNB2 | cyclin B2 | -4.83591 |
| MAPK13 | mitogen-activated protein kinase 13 | -4.71234 |
| TLCD3A | TLC domain containing 3A | -4.62884 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -3.78745 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.76394 |
| THAP11 | THAP domain containing 11 | -3.58876 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.49616 |
| CCDC86 | coiled-coil domain containing 86 | -2.95014 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -2.92324 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -2.90255 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -2.86627 |
| GNAS | GNAS complex locus | -2.84889 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.7956 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.79305 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.73844 |
| GTPBP8 | GTP-binding protein 8 (putative) | -2.70828 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.551 |
| UGDH | UDP-glucose 6-dehydrogenase | -2.53095 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.49857 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | -2.46526 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -2.44737 |
| CCNB1 | cyclin B1 | -2.34777 |
| PCNA | proliferating cell nuclear antigen | -2.33857 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -2.31706 |
| WASHC4 | WASH complex subunit 4 | -2.15693 |
| TLR4 | toll-like receptor 4 | -2.13758 |
| LRRC41 | leucine rich repeat containing 41 | -2.13504 |
| SNX11 | sorting nexin 11 | -2.03172 |
