| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | kepone 10.6 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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108 genes differentially expressed following the CRCGN009_HEPG2_24H:M20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KIFBP | kinesin family binding protein | 7.23179 |
| LCN2 | lipocalin 2 | 6.98143 |
| CNPY3 | canopy FGF signaling regulator 3 | 6.96155 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 6.76072 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 5.74677 |
| MAP7 | microtubule-associated protein 7 | 5.27001 |
| PNKP | polynucleotide kinase 3'-phosphatase | 5.18636 |
| CYCS | cytochrome c, somatic | 4.86598 |
| STAP2 | signal transducing adaptor family member 2 | 4.03 |
| UBQLN2 | ubiquilin 2 | 3.90035 |
| INPP1 | inositol polyphosphate-1-phosphatase | 3.71577 |
| LOC122526780 | uncharacterized LOC122526780 | 3.68171 |
| CDC45 | cell division cycle 45 | 3.55929 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.48938 |
| VAT1 | vesicle amine transport 1 | 3.34805 |
| PRR15L | proline rich 15-like | 3.33479 |
| MVP | major vault protein | 3.33393 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.14671 |
| TERT | telomerase reverse transcriptase | 3.08446 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.08291 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 3.03203 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 2.95688 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.76907 |
| ACOT9 | acyl-CoA thioesterase 9 | 2.73444 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 2.7223 |
| TRIB1 | tribbles pseudokinase 1 | 2.64575 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.62288 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 2.61164 |
| PRKCH | protein kinase C, eta | 2.48615 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.46854 |
| NUCB2 | nucleobindin 2 | 2.42253 |
| DSG2 | desmoglein 2 | 2.41466 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.40379 |
| IDE | insulin-degrading enzyme | 2.38273 |
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 2.31131 |
| DNM1 | dynamin 1 | 2.28545 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.27293 |
| GTPBP2 | GTP binding protein 2 | 2.26493 |
| NANOS3 | nanos homolog 3 (Drosophila) | 2.23785 |
| TUBB6 | tubulin, beta 6 class V | 2.23734 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.18917 |
| MTMR6 | myotubularin related protein 6 | 2.15874 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.15091 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.1211 |
| SQOR | sulfide quinone oxidoreductase | 2.11797 |
| CTTN | cortactin | 2.10042 |
| MBNL2 | muscleblind-like splicing regulator 2 | 2.09008 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | 2.08492 |
| THBS3 | thrombospondin 3 | 2.07406 |
| IER3 | immediate early response 3 | 2.05193 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.04948 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -10.0 |
| TLR4 | toll-like receptor 4 | -8.14192 |
| ISOC1 | isochorismatase domain containing 1 | -7.64663 |
| LAP3 | leucine aminopeptidase 3 | -6.7989 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -6.29054 |
| PCNA | proliferating cell nuclear antigen | -6.23406 |
| CCNB2 | cyclin B2 | -5.97852 |
| CCNB1 | cyclin B1 | -5.55286 |
| CDC20 | cell division cycle 20 | -4.51477 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -4.36758 |
| UGDH | UDP-glucose 6-dehydrogenase | -4.13375 |
| CSK | c-src tyrosine kinase | -4.00919 |
| ADI1 | acireductone dioxygenase 1 | -3.84582 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.78998 |
| HAT1 | histone acetyltransferase 1 | -3.62611 |
| DNM1L | dynamin 1-like | -3.37018 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -3.29518 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -3.28688 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.08189 |
| FHL2 | four and a half LIM domains 2 | -3.04106 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.02532 |
| SMNDC1 | survival motor neuron domain containing 1 | -2.89574 |
| RBM15B | RNA binding motif protein 15B | -2.83904 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.82604 |
| CHMP4B | charged multivesicular body protein 4B | -2.82107 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.79938 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.79233 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.77221 |
| CD320 | CD320 molecule | -2.74072 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.72344 |
| NGRN | neugrin, neurite outgrowth associated | -2.6387 |
| AURKB | aurora kinase B | -2.58723 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.54803 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | -2.54651 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.49673 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | -2.49378 |
| MELK | maternal embryonic leucine zipper kinase | -2.47752 |
| TLCD3A | TLC domain containing 3A | -2.45986 |
| CCNA2 | cyclin A2 | -2.40419 |
| SNX11 | sorting nexin 11 | -2.39998 |
| TRMT5 | tRNA methyltransferase 5 | -2.34844 |
| LMNB1 | lamin B1 | -2.3373 |
| SYNM | synemin, intermediate filament protein | -2.30966 |
| PSMA4 | proteasome (prosome, macropain) subunit, alpha type, 4 | -2.3074 |
| HMG20B | high mobility group 20B | -2.25722 |
| AUNIP | aurora kinase A and ninein interacting protein | -2.21505 |
| PRPF4 | pre-mRNA processing factor 4 | -2.15158 |
| NUP37 | nucleoporin 37kDa | -2.13747 |
| KIF15 | kinesin family member 15 | -2.10262 |
| NUP62 | nucleoporin 62kDa | -2.09515 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -2.06703 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.04468 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -2.04282 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.03882 |
| SCRG1 | stimulator of chondrogenesis 1 | -2.03811 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.0061 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -2.00349 |
